A5008658007- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical synthesis and pharmacological studies
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Heterocycles
- Osteomyelitis and Bone Disorders Research
- Orthopedic Infections and Treatments
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Bone health and treatments
- Chromatography in Natural Products
Belgorod National Research University
2020-2024
First Pavlov State Medical University of St. Petersburg
2024
Luhansk State Medical University
2020-2023
BACKGROUND: An urgent task in pharmacology is to identify highly effective drugs with analgesic and anti-inflammatory activity. Heterocyclic cyanothioacetamide compounds are of considerable interest. Most authors evaluate the results studies separate private indicators activity, their comprehensive criterion assessment insufficiently defined.
 AIM: Development a study activity establishment its generalized criteria for samples chemical medicinal products.
 MATERIALS AND METHODS:...
Introduction. The search for highly effective and safe painkillers is a crucial area of modern pharmacological research. This study aimed to investigate the antinociceptive activity ten novel-condensed thienopyridine 1,4-dihydrothiopyridine derivatives using classic hot plate test. Methods. 340 new cyanothioacetamide synthesized by research laboratory "СhеmEx" Lugansk State University were virtually screened Swiss Target Prediction software package. In vivo screening studies on white rats...
Introduction: It is revelant to solve the problem of anesthesia based on research new highly effective and safe medicines. Among modern studies, preparation heterocyclic compounds starting from cyanothioacetamide with analgesic anti-inflammatory activities considerable interest. Materials Methods: болевой синдром Results: shown that all studied 1,4-dihydropyridines condensed thieno[2,3-b]pyridines reveal activity varying degrees severity, values criterion Anat. Discussion: was found most...
Background . α-сyanothioacetamide derivatives are promising targets for the search effective and safe antinociceptive agents with antipyretic antiexudative activity. The aim To conduct in vivo experimental study of anti-inflammatory analgesic effects new thienopyridines 1,4-dihydropyridines derivatives. Materials methods synthesized cyanothioacetamide were subjected to virtual bioscreening using Swiss Target Prediction online service. 140 laboratory rats randomly distributed into intact...
Purulent-inflammatory diseases of the maxillary system remain one urgent problems in work dentists and maxillofacial surgeons due to high frequency, increased severity prevalence process, a tendency relapse, antibiotic resistance long period uncontrolled use latter by population. The choice bisphosphonate-associated osteomyelitis model is due, on hand, widespread this group number malignant neoplasms, osteoporosis, and, other, frequent development osteonecrosis jaw as complication...
Objective: determination of the relationship between results in silico and vivo studies hypoglycemic, hypolipidemic, hepatoprotective properties a new 1,4-dihydropyridine derivative coded AZ-383. Material methods. Virtual bioscreening compound AZ-383 was carried out using Swiss Target Prediction programs. The identified biotargets were promising for pharmacocorrection complex metabolic disorders, which confirmed an experiment conducted on male Wistar rats. In vivo, levels glucose, total...
The relevance of this study is due to the high number side effects caused by nonsteroidal anti-inflammatory drugs. Our previous studies consecrated , antipyretic and analgesic bioactivity tetrahydropyridines hexahydroquinolines, derivatives α-cyanothioacetamide. Objective. objective was determine acute oral toxicity in vivo new tetrahydropyridine hexahydroquinoline derivatives, α-cyanothioacetamide, with laboratory codes Т D0364, D0353, D0351, CV036, CV125 OC05184. Materials methods....
Introduction: Due to widespread inflammatory processes, often accompanied by pain and fever syndromes, NSAIDs are now the most prescribed drug group in world. characterized taking a leading position number severity of adverse actions. In recent decades, efforts scientists have been aimed at seaching for adequate ways increase safety profile NSAIDs.
 Materials methods: series experiments, main objects research were derivatives α-cyanothioacetamide – new tetrahydropyridones under...