A5021608269- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Birth, Development, and Health
- Genetic and phenotypic traits in livestock
- Dental materials and restorations
- Adipose Tissue and Metabolism
- Vitamin D Research Studies
- Diet and metabolism studies
- Thyroid Cancer Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Cholesterol and Lipid Metabolism
- Artificial Intelligence in Healthcare
- Musculoskeletal pain and rehabilitation
- Dental Erosion and Treatment
Shahid Beheshti University of Medical Sciences
2018-2025
Research Institute for Endocrine Sciences
2018-2025
Shiraz University of Medical Sciences
2024
Shahid Beheshti University
2020-2023
Islamic Azad University of Tabriz
2023
Shariati Hospital
2023
Tehran University of Medical Sciences
2023
Wollongong Hospital
2023
Mashhad University of Medical Sciences
2017-2022
Tarbiat Modares University
2022
Abstract Background Traditional observational studies have shown positive associations between c-reactive protein (CRP) and heart failure (HF) risk. However, this association has not been fully elucidated. Therefore, Mendelian randomization was used to examine CRP’s possible etiological roles with HF. Methods We implemented a two-sample framework the causality of CRP HF based on summary statistics by large-scale genome-wide (GWAS) datasets European ancestry through inverse-variance weighted,...
This study aimed to assess possible changes in mineral intake correlation between family pairs over time. Mineral was measured using a food frequency questionnaire. FCOR command of the Statistical Analysis for Genetic Epidemiology software used determine coefficients minerals relative pairs. Our first analysis conducted on adults (n = 748) who had four complete dietary and familial data third sixth surveys Tehran Lipid Glucose Study. In addition, we assessed respectively 3-year, 6-year,...
To provide an applied framework for assessing the genetic contribution to assortative mating (AM) using height as a model trait and disclose trace of certain pieces evidence AM in form shared environmental effects from long-term cohabitation on spouses' anthropometric traits lipid serum levels. 2315 genotyped couples were extracted Tehran Cardiometabolic Genetic Study (TCGS). Pearson correlation analysis was used assess relationship between height. The GCTA-GREML SNP-based heritability...
The linear mixed-effects model (LME) is a conventional parametric method mainly used for analyzing longitudinal and clustered data in genetic studies. Previous studies have shown that this can be sensitive to assumptions provides less predictive performance than non-parametric methods such as random effects-expectation maximization (RE-EM) unbiased RE-EM regression tree algorithms. These trees utilize classification (CART) conditional inference (Ctree) estimate the fixed-effects components...
The objective of the present systematic review was to incorporate previous studies investigating association birth order with risk systolic and diastolic blood pressure (DBP). We employed random-effects Bayesian meta-analyses, complemented by subgroup sensitivity analyses, including funnel plots, Begg's rank correlation test, Egger's linear regression Galbraith leave-one-out meta-analysis. Of 13 articles analyzed, 92% (12 articles) were published from 2010 onwards. aggregate sample comprised...
The genetic variations among individuals are one of the notable factors determining disease severity and drug response. Nowadays, COVID-19 pandemic has been adversely affecting many aspects human life. We used Tehran Cardio-Metabolic Genetic Study (TCGS) data that is an ongoing study including whole-genome sequencing 1200 chip genotyping more than 15,000 participants. Here, effect ACE2 by focusing on receptor-binding site SARS-CoV-2 cleavage TMPRSS2 protease were investigated through...
BackgroundMetabolic syndrome (MetS) is accompanied by chronic low-grade inflammation, and inflammatory markers like high-sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6), homocysteine(Hcy) contribute to obesity, insulin resistance. Adiponectin(AdipoQ) interleukin-10(IL-10) are anti-inflammatory that play protective roles in MetS. This study aimed investigate the association between these biochemical marker changes MetS a sample of Tehranian population during six years...
Missing data is a pervasive problem in longitudinal analysis. Several single-imputation (SI) and multiple-imputation (MI) approaches have been proposed to address this issue. In study, for the first time, function of regression tree algorithm as non-parametric method after imputing missing using SI MI was investigated simulated real data.Using different simulation scenarios derived from set, we compared performance cross, trajectory mean, interpolation, copy-mean, methods (27 approaches)...
The aim of the present study was to investigate association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients. In total, 90 participants including 60 PTC patients (15 males 45 females) 30 individuals benign multinodular goiter (MNG) (5 25 which were confirmed by surgical pathology, investigated. MMP-9 evaluated at both mRNA protein levels, using SYBR-Green Real-Time PCR...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a promising therapeutic molecule. Epigenetic mechanisms, including non-coding RNAs, regulate the expression level of PPARγ gene.We aimed to examine in non-diabetic individuals four body mass index (BMI) categories and its association with miR-34a miR-143 expression.Visceral subcutaneous adipose tissues (VAT SAT) samples were collected from patients undergoing bariatric or elective open abdominal surgeries. The subjects (mean age:...
There are many human injuries induced by occupational accidents in construction industries. Determination and analysis of accidents' contributing factors is a good way to prevention reduction. Therefore, this study was done view identification analyzing related frequency severity the big This analytical-cross sectional implemented on 500 during five years Iraninan sites. Data gathering based accident report form information were all reviewed accidents. carried out using statistical tests...
Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite simultaneous association favorable unfavorable components. We decided to evaluate these findings a cohort study large sample size of Iranian adult subjects, our knowledge for first time. investigated GCKR incident MetS mean follow-up times nearly 10 years.Analysis this retrospective was performed among 5666...
Introduction The coronary slow flow phenomenon (CSFP) finding in angiography is characterized by the delayed filling of terminal vessels without significant epicardial disease. endothelium performs a vital role cardiovascular homeostasis releasing vasoactive substances. Endothelial cells produce nitric oxide (NO) as one these essential compounds. Three isoforms synthase (NOS) are endothelial (eNOS), neuronal (nNOS), and induced (iNOS). We aimed to determine NOS development CSFP first human...
Abstract In the current study, we aimed to review evidence from twin and family‐based studies that have assessed familial similarity in intakes of energy macronutrients among various parent–child pairs. The online literature databases, including Web Science, PubMed, Scopus, were searched up December 2022 find potentially eligible studies. We converted Pearson's, Spearman's, or intra‐class correlation coefficients z's using Fisher's z transformation obtain approximate normality then...
Maturity-onset diabetes of the young (MODY) is an uncommon monogenic type mellitus. Detecting genetic variants for MODY a necessity precise diagnosis and treatment. The majority predisposition has been documented in European populations lack information present Iranians which leads to misdiagnosis as consequence defects unknown variants. In this study, using variant 20,002 participants from family-based TCGS (Tehran Cardiometabolic Genetic Study) cohort, we evaluated spectrum Iran. We...
In recent decades, ongoing GWAS findings discovered novel therapeutic modifications such as whole-genome risk prediction in particular. Here, we proposed a method based on integrating the traditional genomic best linear unbiased (gBLUP) approach with information to boost genetic accuracy and gene-based heritability estimation. This study was conducted framework of Tehran Cardio-metabolic Genetic (TCGS) containing 14,827 individuals 649,932 SNP markers. Five subsets were selected results: top...
In addition to physical disorders, people with hemophilia face complex psychological problems. Hence, protective factors such as coping strategies, social support, and spirituality improve health should be determined. This study examined the role of courageous a mediator in interrelationships between well support resilience among adolescents hemophilia. this descriptive-analytical study, participants were 372 aged 11-21 years. Connor-Davidson scale, Jalowiec Coping Perceived Social Support...