A5007583931- Bone health and osteoporosis research
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Planetary Science and Exploration
- Neurotransmitter Receptor Influence on Behavior
- Foot and Ankle Surgery
- Total Knee Arthroplasty Outcomes
- Rocket and propulsion systems research
- Space Exploration and Technology
- Shoulder and Clavicle Injuries
- Nicotinic Acetylcholine Receptors Study
- Spaceflight effects on biology
- Behavioral and Psychological Studies
- Orthopedic Infections and Treatments
- Lower Extremity Biomechanics and Pathologies
- Nerve Injury and Rehabilitation
- Bone health and treatments
- Spacecraft Dynamics and Control
- Management of metastatic bone disease
- Spacecraft and Cryogenic Technologies
- Receptor Mechanisms and Signaling
- Gas Dynamics and Kinetic Theory
- Biochemical Analysis and Sensing Techniques
University of Iowa
2018-2024
University of Iowa Hospitals and Clinics
2022-2023
Duke Medical Center
2010-2021
Duke University Hospital
2010-2021
National Institute on Aging
1979-2019
Case Western Reserve University
2019
Worcester Polytechnic Institute
2014-2018
Savannah River National Laboratory
2016
Duke University
2012-2015
University of Kansas
2008-2014
Lorcaserin, a selective 5-hydroxytryptamine<sub>2C</sub> (5-HT<sub>2C</sub>) agonist, has been shown to facilitate weight loss in obese populations. It was assessed for its efficacy reducing nicotine self-administration young adult female Sprague-Dawley rats. The effect of short-term doses (subcutaneous) on (0.03 mg/kg per infusion) with fixed ratio 1 schedule 3-h sessions. Short-term lorcaserin (0.3125–20 mg/kg) were administered counterbalanced order. Significant reduction achieved all the...
Background Caffeine, alcohol, and nicotine are 3 of the most widespread self-administered psychoactive substances, which known to be extensively co-administered. However, little is about degree they may mutually potentiate each other's consumption. Methods In current set studies, we examined in rats effect caffeine administration on alcohol drinking intravenous (i.v.) self-administration nicotine. male alcohol-preferring (P) rats, (5, 10, 20 mg/kg) or saline vehicle was administered acutely...
Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function implicated in hippocampal neurogenesis but cellular source of hippocampus remains ill defined. Here, we utilize gene expression tracer allele (Shh-nlacZ) which allowed identification subpopulation hilar neurons known as mossy cells (MCs) prominent dynamic within dentate gyrus. AAV-Cre mediated ablation...
ABSTRACT Although strong evidence exists that certain activities can increase bone density and structure in people, it is unclear what specific mechanical factors govern the response. This important because understanding effect of signals on could contribute to more effective osteoporosis prevention methods efficient clinical trial design. The degree which strain rate magnitude adaptation humans has never been prospectively tested. Here, we studied effects a voluntary upper extremity...
Covers advancements in spacecraft and tactical strategic missile systems, including subsystem design application, mission analysis, materials structures, developments space sciences, processing manufacturing, operations, applications of technologies to other fields.
Abstract The success of uncemented total ankle replacement (TAR) is linked to initial stability because bony ingrowth depends upon limited early micromotion. Tibial implant design fixation features resist micromotion aided by sidewall retention and interference fit. Our goal was investigate factors influencing implant‐bone in TAR. Two TAR tibial components were virtually inserted into CT‐derived computer models two distal tibias from patients with end‐stage arthritis. Density‐based...
Covers advancements in spacecraft and tactical strategic missile systems, including subsystem design application, mission analysis, materials structures, developments space sciences, processing manufacturing, operations, applications of technologies to other fields.
Bone adaptation is understood to be driven by mechanical strains acting on the bone as a result of some stimuli. Although strain/adaptation relation has been extensively researched using in vivo animal loading models, it not studied humans,likely due difficulties quantifying and living humans. Our purpose was examine relationship between strain changes mineral parameters at local level. Serial computed tomography (CT) scans were used calculate 14 week distal radius for 23 women participating...
Abstract We investigated the effects of scapholunate ligament injury on in vivo radiocarpal joint mechanics using image‐based surface contact modeling. Magnetic resonance images 10 injured and contralateral normal wrists were acquired at high resolution (hand relaxed) during functional grasp. Three‐dimensional models radioscaphoid radiolunate articulations constructed from relaxed images, image registration between grasp provided kinematics. The displacement driven implemented modeling...
This study was undertaken to assess magnetic resonance imaging (MRI)-based radiocarpal surface contact models of functional loading in a clinical MRI scanner for future vivo studies, by comparison with experimental measures from three cadaver forearm specimens. Experimental data were acquired using Tekscan sensor during simulated light grasp. Magnetic (MR) images used obtain model geometry and kinematics (image registration). Peak pressures (PPs) average (APs), forces areas determined the...
In 2011 over 1.7 million people were hospitalized because of a fragility fracture, and direct costs associated with osteoporosis treatment exceeded 70 billion dollars in the United States. Failure to reach maintain optimal peak bone mass during adulthood is critical factor determining fracture risk later life. Physical activity widely accessible, low cost, highly modifiable contributor health. Here, we will review evidence linking exercise physical health women. Bone structure quality be...
While weight-bearing and resistive exercise modestly increases aBMD, the precise relationship between physical activity bone microstructure, strain in humans is not known. Previously, we established a voluntary upper-extremity loading model that assigns person's target force based on their subject-specific, continuum FE-estimated radius strain. Here, our purpose was to quantify inter-individual variability microstructure explained by site-specific mechanical history, determine whether...
The home lift, position, and rehabilitation (HLPR) chair has a unique design novel capabilities when compared with conventional powered wheelchairs. In addition to mobility, it provides lift can transfer patients. Even though medical devices are developing at rapid pace today, an aspect that is often overlooked in these developments adherence “rider safety standards.” contributions of this paper threefold: (i) system, (ii) experiments results toward improved stability test designs include...
Developing novel and selective compounds that desensitize α4β2 nicotinic acetylcholine receptors (nAChRs) could provide new effective treatments for nicotine addiction, as well other disorders. Here we report a class of nAChR ligands display high selectivity picomolar binding affinity receptors. The have Ki values in the range 0.031-0.26 nM properties should make them good candidates drugs acting CNS. selected lead compound 1 (VMY-2-95) binds with potently desensitizes nAChRs. At dose 3...
Joint injuries and the resulting posttraumatic osteoarthritis (OA) are a significant problem. There is still need for tools to evaluate joint injuries, their effect on mechanics, relationship between altered mechanics OA. Better understanding of OA may aid in development or refinement treatment methods. This be partially achieved by monitoring changes that direct consequence injury. Techniques such as image-based finite element modeling can provide vivo data but also laborious...