A5051573298- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Genetic Associations and Epidemiology
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Gene expression and cancer classification
- Cardiac Imaging and Diagnostics
- Genetic Mapping and Diversity in Plants and Animals
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Statistical Methods and Inference
- Elasticity and Material Modeling
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- RNA Research and Splicing
- Statistical Methods in Clinical Trials
- Automotive and Human Injury Biomechanics
- Bioinformatics and Genomic Networks
- Statistical Methods and Bayesian Inference
- Amyotrophic Lateral Sclerosis Research
- Statistical Distribution Estimation and Applications
- Bayesian Methods and Mixture Models
- Genomics and Rare Diseases
- Advanced Statistical Methods and Models
Worcester Polytechnic Institute
2015-2024
University of Poonch Rawalakot
2020
Jiangxi Agricultural University
2020
University of Azad Jammu and Kashmir
2020
Yale University
2006-2014
Carnegie Mellon University
2014
University of New Orleans
2005
ABSTRACT Tsetse flies ( Glossina spp.) can harbor up to three distinct species of endosymbiotic bacteria that exhibit unique modes transmission and evolutionary histories with their host. Two mutualist enterics, Wigglesworthia Sodalis , are transmitted maternally tsetse flies' intrauterine larvae. The third symbiont, from the genus Wolbachia parasitizes developing oocytes. In this study, we determined isolates several fly virtually identical based on a phylogenetic analysis ftsZ gene...
Developing an accurate and reliable injury predictor is central to the biomechanical studies of traumatic brain injury. State-of-the-art efforts continue rely on empirical, scalar metrics based kinematics or model-estimated tissue responses explicitly pre-defined in a specific region interest. They could suffer from loss information. A single training dataset has also been used evaluate performance but without cross-validation. In this study, we developed deep learning approach for...
Using a combination of deep sequencing and bioinformatics approach, we for the first time identify miRNAs their relative abundance in mature, metaphase II arrested eggs Xenopus laevis. We characterize 115 that have been described either tropicalis (85), X. laevis (9), or other vertebrate species (21) also map to known pre-miRNAs genome. In addition, 72 new putative candidate are identified based on mapping genome within regions propensity form hairpin loops. These data expand availability...
// Marisa Mariani 1,2 , Mark McHugh 1 Marco Petrillo 2 Steven Sieber Shiquan He Mirko Andreoli Zheyang Wu 3 Paul Fiedler Giovanni Scambia 2,4 Shohreh Shahabi 1,* and Cristiano Ferlini 1,4,* Danbury Hospital Research Institute, Danbury, CT, USA Department of Gynecology, Catholic University the Sacred Heart, Rome, Italy Mathematical Sciences, Worcester Polytechnic Worcester, MA, 4 Oncology, Jean IInd Foundation, Campobasso, * These Authors equally contributed to this work Correspondence:...
Plaque vulnerability, defined as the likelihood that a plaque would rupture, is difficult to quantify due lack of in vivo rupture data. Morphological and stress-based vulnerability indices were introduced alternatives obtain quantitative assessment. Correlations between these key features investigated. In intravascular ultrasound (IVUS) data acquired from 14 patients IVUS-based 3D fluid-structure interaction (FSI) coronary models with cyclic bending constructed wall stress/strain flow shear...
Background Accurate calculation of ventricular stress and strain is critical for cardiovascular investigations. Sarcomere shortening in active contraction leads to change zero-stress configurations during the cardiac cycle. A new model using different zero-load diastole systole geometries was introduced provide more accurate stress/strain calculations with potential predict post pulmonary valve replacement (PVR) surgical outcome. Methods Cardiac magnetic resonance (CMR) data were obtained...
ABSTRACT Although strong evidence exists that certain activities can increase bone density and structure in people, it is unclear what specific mechanical factors govern the response. This important because understanding effect of signals on could contribute to more effective osteoporosis prevention methods efficient clinical trial design. The degree which strain rate magnitude adaptation humans has never been prospectively tested. Here, we studied effects a voluntary upper extremity...
Abstract Combining dependent tests of significance has broad applications but the related p-value calculation is challenging. For Fisher's combination test, current methods (eg, Brown's approximation) tend to inflate type I error rate when desired level substantially less than 0.05. The problem could lead significant false discoveries in big data analyses. This paper provides two main contributions. First, it presents a general family Fisher statistics, referred as GFisher, which covers many...
Genome-wide association studies (GWAS) aim to identify genetic variants related diseases by examining the associations between phenotypes and hundreds of thousands genotyped markers. Because many genes are potentially involved in common a large number markers analyzed, it is crucial devise an effective strategy truly associated that have individual and/or interactive effects, while controlling false positives at desired level. Although model selection methods been proposed literature,...
Genome-wide association studies (GWAS) have identified many genetic factors underlying complex human traits. However, these explained only a small fraction of traits' heritability. It is argued that more remain undiscovered. These likely are weakly associated at the population level and sparsely distributed across genome. In this paper, we adapt recent innovations on Tukey's Higher Criticism (Tukey [The (1976) Princeton Univ.]; Donoho Jin [Ann. Statist. 32 (2004) 962–994]) to SNP-set...
Arteries can be considered as layered composite material. Experimental data on the stiffness of human atherosclerotic carotid arteries and their media adventitia layers are very limited. This study used uniaxial tests to determine (tangent modulus) artery sections containing American Heart Association type II III lesions. Axial circumferential oriented adventitia, media, full thickness specimens were prepared from six (total tissue strips: 71). Each yielded 12 with two in each following...
Increasing evidence suggests that mechanisms governing advanced plaque progression may be different from those for early and require further investigation. Serial MRI data 3D fluid–structure interaction (FSI) models were employed to identify possible correlations between mechanical stresses measured by vessel wall thickness increase (WTI). Long-term patient follow up was used gather investigate if the identified above reproducible. In vivo acquired 16 patients in a follow-up study with 2 4...
CRC cancer is one of the deadliest diseases in Western countries. In order to develop prognostic biomarkers for (colorectal cancer) aggressiveness, we analyzed retrospectively 267 patients via a novel, multidimensional biomarker platform. Using nanofluidic technology qPCR analysis and quantitative fluorescent immunohistochemistry protein analysis, assessed 33 microRNAs, 124 mRNAs 9 antigens. Analysis was conducted each single dimension (microRNA, gene or protein) using both multivariate Cox...
The $p$-value combination approach is an important statistical strategy for testing global hypotheses with broad applications in signal detection, meta-analysis, data integration, etc. In this paper we extend the classic Fisher's method to a unified family of statistics, called TFisher, which allows general truncation-and-weighting scheme input $p$-values. TFisher can significantly improve power over Fisher and related truncation-only methods detecting both rare dense "signals." To address...
Abstract Head injury model validation has evolved from against pressure to relative brain–skull displacement, and more recently, marker-based strain. However, there are concerns on strain data quality. In this study, we parametrically investigate how displacement random errors synchronization propagate into Embedded markers four representative configurations used form unique nonoverlapping tetrahedrons, triangles, linear elements. Marker displacements then separately subjected up ±10% ±2 ms...
The identification of several hundred genomic regions affecting disease risk has proven the ability genome-wide association studies have their to identify genetic contributors disease. Currently, single-nucleotide polymorphism (SNP) analysis is most widely used method data, but recent research shows that multi-marker tests may provide greater power, especially when more than one mutation present within a gene and mutations are in low linkage disequilibrium with each other. Here we use test...
It has been hypothesized that mechanical risk factors may be used to predict future atherosclerotic plaque rupture. Truly predictive methods for rupture and identify the best predictor(s) from all candidates are lacking in literature. A novel combination of computational statistical models based on serial magnetic resonance imaging (MRI) was introduced quantify sensitivity specificity predictors candidate site prediction. Serial vivo MRI data carotid one patient acquired with follow-up scan...