A5000048821- Asthma and respiratory diseases
- Gut microbiota and health
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Clinical Nutrition and Gastroenterology
- Streptococcal Infections and Treatments
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- Neonatal and Maternal Infections
- Diet and metabolism studies
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Probiotics and Fermented Foods
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- Gallbladder and Bile Duct Disorders
- Infectious Diseases and Tuberculosis
- IL-33, ST2, and ILC Pathways
University Hospital Waterford
2025
University College Cork
2012-2024
APC Microbiome Institute
2017-2024
Mater Misericordiae University Hospital
2024
Cork University Hospital
2020-2021
Murdoch Children's Research Institute
2013-2017
Royal Children's Hospital
2015
National University of Ireland
2009-2014
Following small bowel resection (SBR), the luminal environment is altered, which contributes to clinical manifestations of short syndrome (SBS) including malabsorption, mucosal inflammation and bacterial overgrowth. However, impact SBR on colon has not been well-defined. The aims this study were characterize colonic microbiota following assess in colon.Analysis demonstrated that there was a significant level dysbiosis both two six weeks post-SBR, particularly phylum Firmicutes, coupled with...
Summary Citrobacter rodentium is a murine pathogen that transiently colonizes the lumen of large intestine. C. induces colitis, but relative importance and temporal induction T helper type 17 (Th17) regulatory cell (Treg) pathways in protection from infection inflammation have not been assessed. Our aim was to investigate key immunological signalling events associated with successful clearance rodentium. Mice were challenged luminescent-tagged killed at days 3 (early infection), 10 (peak...
Introduction. Carbapenems are usually employed as first-line antimicrobials against bacteria harbouring extended-spectrum beta-lactamases (ESBLs). These enzymes confer resistance often to multiple classes of antimicrobials. Hypothesis/Gap Statement. This indiscriminate use carbapenems and the inevitable development carbapenem have prompted need for carbapenem-sparing strategies. Methodology. The non-carbapenem antimicrobial susceptibility patterns 60 ESBL-producing Enterobacterales (ESBL-PE)...
OBJECTIVES: Salmonella-induced damage to the small intestine may decrease villi-associated enzyme activity, causing malabsorption of nutrients and diarrhea, thus contribute symptoms infection. The objective this study was determine mechanism by which different doses durations ofSalmonellainfection lipopolysaccharide (LPS) affect brush border activity in mouse, if probioticBifidobacterium longumsubspeciesinfantis35624 could attenuate intestinal damage. METHODS: BALB/c mice were challenged...
To investigate the impact of minor abdominal surgery on caecal microbial population and markers gut inflammation.Four week old piglets were randomly allocated to a no-surgery "control" group (n = 6) or "transection surgery" 5). During transection procedure, conventional midline incision lower wall was made small intestine transected at site 225 cm proximal ileocaecal valve, 2 segment removed re-anastomosed. Piglets received polymeric infant formula diet throughout study period sacrificed two...
Varying concentrations of lipopolysaccharide (LPS) in ovalbumin (OVA) may influence the airway response to allergic sensitization and challenge. We assessed contribution LPS inflammatory responses following challenge with LPS-rich LPS-free commercial OVA. BALB/c mice were sensitized OVA alum then underwent same (10 µg intranasally) or an Following challenge, bronchoalveolar lavage (BAL), responsiveness methacholine lung regulatory T cell population (Treg) assessed. Both preparations induced...
Group A streptococcus (GAS) can cause serious invasive disease in humans with a high mortality rate. An increase GAS infections was reported Ireland 2022, and this has been sustained 2023 is paralleled by similar trends Europe. Rising antimicrobial resistance global problem presents significant challenges to clinicians treating infection. There clindamycin isolates 2022. We examined susceptibility patterns of our institution Although all included study were susceptible penicillin, we noted...
Abstract Background and Aim Short bowel syndrome (SBS) is primarily characterized by malabsorption malnutrition, resulting from loss of intestinal absorptive area following massive small resection (SBR). Bile acids the gut microbiota are functionally linked within gut‐liver axis; however, SBS‐associated disturbances axis remain largely unexplored. The aim this study was to characterize evolution bile acid alterations at both short‐term long‐term time points relate these changes in colonic...
Different rates of bacterial translocation across the gut mucosa have been reported but few studies examined commensals at level epithelial microfold (M) cell. We used an in vitro M-cell model to quantify and determine transcriptional response M cells various commensal bacteria. The transport kinetics gene expression profile different strains, namely Lactobacillus salivarius, Escherichia coli Bacteroides fragilis, was assessed. Bacterial strains translocated with efficiencies; E. B. fragilis...
Abstract Background It is suggested that airway fungi, in particular Aspergillus may impinge on clinical phenotype asthma. Indeed, the term severe asthma with fungal sensitization (SAFS) has been coined. We aimed to ascertain whether presence of fumigatus , correlated severity and control. Furthermore, we determine traditional markers related within airway. Methods Sixty‐nine patients characterized by (GINA) level control (ACQ‐7) underwent bronchoscopy bronchoalveolar lavage (BAL). Serum was...
Abstract Liver disease is a major source of morbidity and mortality in children with short bowel syndrome (SBS). SBS-associated microbial dysbiosis has recently been implicated the development liver (SBS-ALD), however pathological implications this association have not explored. In study high-throughput sequencing colonic content from well-validated piglet SBS-ALD model was examined to determine alterations communities, concurrent metabolic identified urine samples via targeted mass...
Group A streptococcus (GAS) can cause serious invasive disease in humans with a high mortality rate. An increase GAS infections was reported Ireland 2022, and this has been sustained 2023 is paralleled by similar trends Europe. Rising antimicrobial resistance global problem presents significant challenges to clinicians treating infection. There clindamycin isolates 2022. We examined susceptibility patterns of our institution Although all included study were susceptible penicillin, we noted...
Immunoglobulins play a vital role in host immune response and the pathogenesis of conditions like asthma. Therapeutic agents such as monoclonal antibodies target specific elements asthmatic inflammatory cascade. Decisions to utilize these medications are often based on systemic profiling without direct insight into airway profile. We sought investigate relationship between immunoglobulin cytokine profiles compartments adult asthmatics.
Objective This study investigated seroprevalence of SARS-CoV-2-specific IgG antibodies, using the Abbott antinucleocapsid chemiluminescent microparticle immunoassay (CMIA) assay, in five prespecified healthcare worker (HCW) subgroups following first wave COVID-19 pandemic. Setting An 800-bed tertiary-level teaching hospital south Ireland. Participants Serum was collected for anti-SARS-CoV-2 nucleocapsid ARCHITECT SARS-CoV-2 CMIA qualitative as per manufacturer’s specifications. The groups...
Group A streptococcus (GAS) can cause serious invasive disease in humans with a high mortality rate. An increase GAS infections was reported Ireland 2022, and this has been sustained 2023 is paralleled by similar trends Europe. Rising antimicrobial resistance global problem presents significant challenges to clinicians treating infection. There clindamycin isolates 2022. We examined susceptibility patterns of our institution Although all included study were susceptible penicillin, we noted...
Group A streptococcus (GAS) can cause serious invasive disease in humans with a high mortality rate. An increase GAS infections was reported Ireland 2022, and this has been sustained 2023 is paralleled by similar trends Europe. Rising antimicrobial resistance global problem presents significant challenges to clinicians treating infection. There clindamycin isolates 2022. We examined susceptibility patterns of our institution Although all included study were susceptible penicillin, we noted...
A 77-year-old Lithuanian man presented to our institution with recurrent episodes of periorbital cellulitis, submandibular swelling and sialadenitis. Investigations revealed a positive QuantiFERON, raised inflammatory markers normal autoimmune screen. Cross-sectional imaging showed no signs occult malignancy, work-up for mycobacterial infection including bronchoalveolar lavage did not show active tuberculosis. During hospitalisation, the patient developed fevers unknown origin, which were...
Long Term Disruption of Cytokine Signalling Networks are Evident Following SARS-CoV-2 InfectionSinead Ahearn-Ford1, Nonhlanhla Lunjani1, Brian McSharry1,2, John MacSharry1,2,3, Liam Fanning1,3, Gerard Murphy4, Cormac Everard4, Aoife Barry4, Aimee McGreal4, Sultan Mohamed al Lawati4, Susan Lapthorne4, Colin Sherlock4, Anna McKeogh4, Arthur Jackson4, Eamonn Faller4, Mary Horgan3,4, Corinna Sadlier4, O'Mahony1,2,3*1APC Microbiome Ireland, University College Cork, Ireland2School Microbiology,...
A fit middle aged man presented to the emergency department with headache, myalgia, vomiting, fever and rigours. He was hypotensive mottled peripheries, tachycardic dyspnoeic. The only significant medical history noted an splenectomy 30 years previously following a road traffic accident. patient had been on prophylactic antibiotics initially vaccinated in line recommendations at time no health issues intervening years. treated empirically for septic shock meningitis based presentation...