A5030850865- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- Molecular Biology Techniques and Applications
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
University of North Carolina at Chapel Hill
2023-2024
Abstract Whole virus-based inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide have been critical to the COVID-19 pandemic response. Although these are protective against homologous coronavirus infection, emergence of novel variants and presence large zoonotic reservoirs harboring heterologous coronaviruses provide significant opportunities for vaccine breakthrough, which raises risk adverse outcomes like vaccine-associated enhanced respiratory disease. Here, we use a female...
RNA viruses quickly evolve subtle genotypic changes that can have major impacts on viral fitness and host range, with potential consequences for human health. It is therefore important to understand the evolutionary of novel variants relative well-studied genotypes epidemic viruses. Competition assays are an effective rigorous system which assess genotypes. However, it challenging cheaply distinguish quantify differences between very similar Here, we describe a protocol using reverse...
<title>Abstract</title> Inactivated whole virus SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide (Alum) are among the most widely used COVID-19 globally and have been critical to pandemic response. Although these protective against homologous infection in healthy recipients, emergence of novel variants presence large zoonotic reservoirs provide significant opportunities for vaccine breakthrough, which raises risk adverse outcomes including vaccine-associated enhanced respiratory...