A5089369891- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Electrochemical sensors and biosensors
- Innovative Microfluidic and Catalytic Techniques Innovation
- Blood properties and coagulation
- Cancer Cells and Metastasis
- AI in cancer detection
- Clinical Laboratory Practices and Quality Control
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Cell Image Analysis Techniques
- Biosensors and Analytical Detection
- Enzyme Catalysis and Immobilization
- SARS-CoV-2 detection and testing
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Cholinesterase and Neurodegenerative Diseases
TU Wien
2020-2024
Austrian Cluster for Tissue Regeneration
2020
Abstract Physiological‐relevant in vitro tissue models with their promise of better predictability have the potential to improve drug screening outcomes preclinical studies. Despite advances spheroid pharmaceutical applications, variations size and consequential altered cell responses often lead nonreproducible unpredictable results. Here, a microfluidic multisize array is established characterized using liver, lung, colon, skin cells as well triple‐culture model blood‐brain barrier (BBB)...
The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models vivo conditions led to a growing effort last decade develop advanced multi-organ-on-a-chip devices. However, many of proposed devices have failed implement means allow tailored each organ individually, crucial aspect cell functionality. Here, we present two 3D-print-based fabrication methods generic device: One with PDMS microfluidic core unit one based on 3D-printed...
Due to advances in additive manufacturing and prototyping, affordable rapid microfluidic sensor-integrated assays can be fabricated using manufacturing, xurography electrode shadow masking create versatile platform technologies aimed toward qualitative assessment of acute cytotoxic or cytolytic events stand-alone biochip platforms the context environmental risk assessment. In current study, we established a nasal mucosa biosensing RPMI2650 cells inside membrane-integrated impedance-sensing...
The presence of neutralizing antibodies against SARS-CoV-2 in blood, acquired through previous infection or vaccination, is known to prevent the (re)occurrence outbreaks unless virus mutates. Therefore, measurement constitutes an indispensable tool assessing individual's and a population's immunity SARS-CoV-2. For this reason, we have developed innovative lateral flow assay (LFA) capable detecting blood-derived using biomimetic mock system. Here, functionalized gold nanoparticles (AuNPs)...
Organophosphates (OPs) and carbamates as insecticides, nematicides, fungicides, herbicides are constantly increasing. Their neurotoxic nature requires careful usage, misuse can lead to fatalities. OPs classified 'Class 1' toxic compounds irreversibly inhibit cholinesterases due their molecular structure resembling the natural acetylcholine substrate, leading events in human brain. Monitoring such chemicals is relevant for agricultural applications essential military sector ensure safety of...
Fibrinogen is a coagulation factor in human blood and the first one to reach critical levels major bleeding. Hypofibrinogenemia (a too low fibrinogen concentration blood) poses great challenges responders, clinicians, healthcare providers since it represents risk for exsanguination massive transfusion requirements. Thus, rapid assessment of at point care has gained considerable importance preventing managing loss. However, whole measurements, hematocrit variations affect amount (volume...
A microfluidic platform with immobilized human flavin-containing monooxygenase for high-throughput screening of drugs relevance to personalised medicine.
Both cerium oxide (CeOx) nanoparticles and mefenamic acid (MFA) are known anti-inflammatory agents with hepatoprotective properties therefore prescribed for one of the major diseases in world, nonalcoholic fatty liver disease (NAFLD). To study potential cytotoxicity effects as well drug retention a therapeutic CeOx/MFA supramolecular complex, well-standardized hepatic (HepG2) spheroid model was used. Results showed that highest complex found at 50 μg/mL, while effective doses 0.1 1 μg/mL...
The outcomes of clinical studies are strongly influenced by their preceding preclinical studies. Due to higher physiological relevance, 3D spheroid arrays can potentially improve drug screening in Analytical accessibility is still limited. To further increase usability and simplify subsequent analyses arrays, the authors present an automated method for analyzing viability. developed easy-to-use workflow provides viability analysis using fluorescence images cell aggregates. It allows early...