A5064989442- Effects and risks of endocrine disrupting chemicals
- Regulation of Appetite and Obesity
- Neonatal Health and Biochemistry
- Thyroid Disorders and Treatments
- Ovarian function and disorders
- Adrenal Hormones and Disorders
- Parathyroid Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Autism Spectrum Disorder Research
- Diabetes Management and Research
- Reproductive Biology and Fertility
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Dermatological and COVID-19 studies
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- Lipid metabolism and disorders
- Genetic Syndromes and Imprinting
- Erythrocyte Function and Pathophysiology
Ondokuz Mayıs University
2020-2025
Erciyes University
2010-2021
Pediatrics and Genetics
2013
Zübeyde Hanim Maternity Hospital
2010
The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), bisphenol A (BPA), 1 endocrine disruptors, among phthalates. included 48 children with disorder (27 boys, 21 girls) 41 healthy subjects (24 17 as controls. Serum MEHP, DEHP, BPA levels were measured by using high-performance liquid chromatography. Children had significantly increased serum concentrations...
Experimental in vitro studies have shown that bisphenol A affects steroidogenesis, folliculogenesis and ovarian morphology. The aim of this study was to investigate the role endocrine disruptor aetiopathogenesis polycystic ovary syndrome (PCOS) adolescents its relationship with metabolic parameters, insulin resistance obesity population.A total 112 girls PCOS 61 controls between 13 19 years age were enrolled study. Serum levels measured by high-pressure liquid chromatography. An oral glucose...
ABSTRACT Background Autosomal recessive severe congenital neutropenia (SCN) has been associated with homozygous variants in the HAX1 gene. The aim of this cross‐sectional study was to evaluate gonadal function and pubertal development pediatric patients SCN due gene variant (HAX1‐SCN). Methods Forty‐five patients, including 24 females (median age 11.3 [1.5–31] years, 13 pubertal, 11 prepubertal), 21 males 9.5 (3–18.8) 7 14 followed seven centers, were included. POI is defined as a menstrual...
Objective: We aimed to investigate a possible role of the endocrine disruptors phthalates, di-2-ethylhexyl phthalate (DEHP) and mono (2-ethylhexyl) (MEHP), in polycystic ovary syndrome (PCOS) aetiopathogenesis.We also wished evaluate relationship between phthalates metabolic disturbances adolescents with PCOS.Methods: A total 124 were included.Serum MEHP DEHP levels determined by high-performance liquid chromatography.Insulin resistance was evaluated using homeostasis model...
Diabetic ketoacidosis (DKA) is an important complication of type 1 diabetes mellitus (T1DM) which worsened when the diagnosis T1DM delayed. The aim this study was to evaluate presentation patterns, severity, autoantibody status, and seasonal variability newly diagnosed patients during pandemic period 2 years compared those in pre-pandemic period.
Vitamin D deficiency rickets (VDDR) is a disorder biochemically characterized by elevated serum alkaline phosphatase (ALP) activity, normal or decreased calcium (Ca) and inorganic phosphate concentrations, secondary hyperparathyroidism 25-hydroxyvitamin (25(OH)D) levels. In stage 1 VDDR, urinary amino acid excretion are with minimal no findings of on radiographs. Pseudohypoparathyroidism (PHP) an inherited end-organ resistance to parathormone (PTH). VDDR occasionally resembles PHP type 2 in...
Thiamine-responsive megaloblastic anaemia (TRMA; OMIM 249270) syndrome is an autosomal recessive disorder characterized by diabetes mellitus, anaemia, and sensorineural deafness. Progressive hearing loss one of the cardinal findings known to be irreversible. Whether deafness in TRMA can prevented not yet known. Here, we report a four-month-old female infant diagnosed with at early age. There was no time diagnosis. The patient's initial auditory evoked brainstem response measurements were...
Pseudohypoaldosteronism type 1 (PHA1) is a monogenic disease caused by mutations in the genes encoding human mineralocorticoid receptor (MR) or α (SCNN1A), β (SCNN1B) γ (SCNN1G) subunit of epithelial Na(+) channel (ENaC). While autosomal dominant mutation MR cause renal PHA1, recessive ENaC lead to systemic PHA1. In latter, affected children suffer from neonatal onset multi-organ salt loss and often exhibit cystic fibrosis-like pulmonary symptoms.We searched for underlying seven unrelated...
Background: Obesity in children increases the risk of atherosclerosis. Endothelial dysfunction is an important factor pathogenesis atherosclerosis, and endothelial microparticles (EMPs) are considered as markers dysfunction. In this study, we aimed to evaluate circulating EMPs obese overweight disclose measure obesity with strongest relation carotid
To investigate the presence of association between nonalcoholic fatty liver disease (NAFLD) and subclinical atherosclerosis using carotid intima media thickness (c-IMT) in obese children adolescents. Additionally, we wished to relationship elevated enzymes.A total 157 patients (78 boys 79 girls, mean age: 11.3 ± 2.6 years, age range: 6-16 years) were enrolled study. Aminotransferase, fasting glucose lipid levels determined. An oral tolerance test was performed. The c-IMT measured. Infectious...
Subcutaneous fat necrosis of the newborn (ScFN) is an uncommon condition caused by generalized and/or local tissue hypoperfusion. The skin lesions ScFN tend to improve spontaneously. However, may also lead complications which cause serious problems. severity etiologic factors contributing development disease determines complications. Therefore, these patients should be closely monitored for complications, especially hypercalcemia life-threatening. and duration are associated with extensity...
Organophosphate (OP) poisoning is common in developing countries. The presenting symptoms and signs of OP intoxication are multiple may cause difficulty differential diagnosis, especially children. A case reported who presented as diabetic keto-acidosis.
Iodine overload frequently leads to transient hyperthyrotropinemia or hypothyroidism, and rarely hyperthyroidism in neonates. exposure can be prenatal, perinatal postnatal. Herein we report two newborn infants who developed severe hypothyroidism due iodine overload. The overloading was caused by excessive use of an iodinated antiseptic for umbilical care the first case, as a result maternal through breast milk with high level second case. Presenting cases, wanted draw attention these...
Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease resulting from resistance to the action of adrenocorticotropic hormone (ACTH) on adrenal cortex, which leads isolated with normal mineralocorticoid secretion. It may present in infancy or early childhood hyperpigmentation, failure thrive, recurrent infections, hypoglycemic attacks and convulsions that result coma death. Laboratory investigations reveal low cortisol androgen levels high ACTH associated...
Radioactive iodine (RAI) is used effectively in the treatment of hyperthyroidism and thyroid cancer, but it contraindicated during pregnancy. RAI pregnancy can lead to fetal hypothyroidism, mental retardation increased malignancy risk infant. Pregnancy tests must be performed before all women reproductive age. However, at times, being ruling out We herein present a male newborn infant with congenital hypothyroidism whose mother was given three-week course methimazole therapy for her multiple...
Subcutaneous fat necrosis of the newborn (ScFN) is an uncommon condition neonates and infants. The disorder caused by generalized local tissue hypoperfusion. ScFN tends to improve spontaneously with or without some severe complications such as hypercalcemia. may occur iatrogenic after hypothermic surgical interventions. We present in a uncomplicated hypercalcemia due cold exposure on operating table during at umbilical cord hernia operation. To our knowledge, this first report patient whom...