A5027670953- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Gene expression and cancer classification
- Mitochondrial Function and Pathology
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Advanced Biosensing Techniques and Applications
École Polytechnique Fédérale de Lausanne
2022-2025
Abstract Transcriptomics has revolutionized biomedical research and refined breast cancer subtyping diagnostics. However, wider use in clinical practice is hampered for a number of reasons including the application transcriptomic signatures as single sample predictors. Here, we present an embedding approach called EMBER that creates unified space 11,000 transcriptomes predicts phenotypes profiles on basis. accurately captures five molecular subtypes. Key biological pathways, such estrogen...
Abstract Breast cancer is a leading cause of cancer-related mortality for women worldwide. Hormone receptor-positive (HR+) breast tumors, which represent 70% all cases, are treated with endocrine therapy. However, not patients benefit from this treatment regimen because patient-to-patient variation. Therefore, high throughput drug screening system warranted to enable personalized medicine. Patient-derived organoids, serve as platform, lose their hormone receptors and response upon ex vivo...