A5085969774- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- Acute Myeloid Leukemia Research
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Advanced biosensing and bioanalysis techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Photodynamic Therapy Research Studies
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Muscle Physiology and Disorders
- Bioinformatics and Genomic Networks
- Inflammatory Myopathies and Dermatomyositis
- Ocular Oncology and Treatments
- S100 Proteins and Annexins
- Hippo pathway signaling and YAP/TAZ
- Advanced Biosensing Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Mesenchymal stem cell research
Genentech
2025
Hôpital Ophtalmique Jules-Gonin
2024
Fondation Asile des Aveugles
2023
University of Lausanne
2023
École Polytechnique Fédérale de Lausanne
2018-2022
American University of Beirut
2016-2020
Abstract More than 70% of human breast cancers (BCs) are estrogen receptor α-positive (ER + ). A clinical challenge ER BC is that they can recur decades after initial treatments. Mechanisms governing latent disease remain elusive due to lack adequate in vivo models. We compare intraductal xenografts and triple-negative (TN) cells demonstrate disseminated TNBC proliferate similarly as at the primary site whereas slower, decrease CDH1 increase ZEB1 , 2 expressions, exhibit characteristics...
Article22 February 2021Open Access Source DataTransparent process Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1 George Sflomos orcid.org/0000-0003-2972-0549 ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland Search more papers by this author Laura Battista orcid.org/0000-0002-9370-6736 Patrick Aouad orcid.org/0000-0001-6568-2151 Fabio...
Estrogens and progesterone control breast development carcinogenesis via their cognate receptors expressed in a subset of luminal cells the mammary epithelium. How they extracellular matrix, important to physiology tumorigenesis, remains unclear. Here we report that both hormones induce secreted protease Adamts18 myoepithelial by controlling Wnt4 expression with consequent paracrine canonical Wnt signaling activation. is required for stem cell activation, has multiple binding partners...
Estrogen receptor α-positive (ER-positive) or 'luminal' breast cancers were notoriously difficult to establish as patient-derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical for ER-positive tumor cells; when grafted single cells into milk ducts of NOD Scid gamma females, >90% tumors can be established recapitulate many features human disease in vivo. This intraductal approach holds promise personalized medicine, yet murine stroma are organized...
Despite recent advances in chemotherapy, aggressive and metastatic breast cancers remain refractory to targeted therapy the development of novel drugs is urgently needed. Retinoids are crucial regulators cellular proliferation, differentiation, cell death, have shown potent chemotherapeutic chemopreventive properties. The major drawback use all-trans retinoic acid (ATRA) cancer disease relapse. Therefore, synthetic retinoids, specifically ST1926, emerged as anticancer agents. Given...
Abstract Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 -2. Oestrogens control postnatal mammary gland development acting on subset of epithelial cells (MECs), termed sensor cells, which are ERα-positive by immunohistochemistry (IHC) secrete paracrine factors, stimulate ERα-negative responder cells. Here we show that deletion AF-1 or AF-2 blocks pubertal ductal growth subsequent because both required for...
Acute myeloid leukemia (AML) is one of the most frequent types blood malignancies. It a complex disorder undifferentiated hematopoietic progenitor cells. The majority patients generally respond to intensive therapy. Nevertheless, relapse major cause death in AML, warranting need for novel treatment strategies. Retinoids have demonstrated potent differentiation and growth regulatory effects normal, transformed, All-trans retinoic acid (ATRA) paradigm acute promyelocytic leukemia, an AML...
Abstract Retinoblastoma is the most common pediatric eye cancer. It currently treated with a limited number of drugs, adapted from other cancer treatments. Drug toxicity and relapse disease warrant new therapeutic strategies for these young patients. In this study, we developed robust tumoroid‐based platform to test chemotherapeutic agents in combination focal therapy (thermotherapy) – treatment option widely used clinical practice accordance clinically relevant trial protocols. The model...
Abstract Estrogen receptor α-positive (ER+) breast cancers (BCs) represent more than 70% of all and pose a particular clinical challenge because they recur up to decades after initial diagnosis treatment. The mechanisms governing tumor cell dormancy latent disease remain elusive due lack adequate models. Here, we compare progression ER+ triple-negative (TN) BC subtypes with clinically relevant mouse intraductal xenografting approach (MIND). Both TN cells disseminate already during the in...
Abstract Breast cancer is a leading cause of cancer-related mortality for women worldwide. Hormone receptor-positive (HR+) breast tumors, which represent 70% all cases, are treated with endocrine therapy. However, not patients benefit from this treatment regimen because patient-to-patient variation. Therefore, high throughput drug screening system warranted to enable personalized medicine. Patient-derived organoids, serve as platform, lose their hormone receptors and response upon ex vivo...
Abstract Despite recent advances in breast cancer therapy, achieving complete remission metastatic patients remains a challenge. Retinoids are crucial regulators of cellular proliferation, differentiation, and cell death, have shown potent chemotherapeutic chemopreventive properties. The major drawback the use all-trans retinoic acid (ATRA) therapy is acquired resistance. Therefore, synthetic retinoids such as ST1926 emerged anti-cancer agents. Here, we investigated anti-tumor activities...
Abstract Colorectal cancer is the third most common neoplasia and second cause of cancer-related deaths worldwide. Unlike normal cells, tumor cells reprogram metabolic pathways to meet their bioenergetics, redox, biosynthetic demands rely mostly on aerobic glycolysis (Warburg effect). upregulate pentose phosphate pathway (PPP), p53 a crucial regulator. The PPP significant route for glucose catabolism required DNA synthesis rapidly-proliferating cells. Its oxidative phase (oxPPP), catalyzed...
<div>Abstract<p>Acute myeloid leukemia (AML) is one of the most frequent types blood malignancies. It a complex disorder undifferentiated hematopoietic progenitor cells. The majority patients generally respond to intensive therapy. Nevertheless, relapse major cause death in AML, warranting need for novel treatment strategies. Retinoids have demonstrated potent differentiation and growth regulatory effects normal, transformed, All-<i>trans</i> retinoic acid (ATRA)...
<p>Supplementary Figure S1. Effect of ST1926 on the viability AML cells; Supplementary S2. normal human stem S3. Representative histogram analysis effects cell cycle distribution Table 1: Peritoneal volumes (cm3) treated (n=5 for each group) versus control mice determined at 24-days post-treatment</p>
<p>Supplementary Figure S1. Effect of ST1926 on the viability AML cells; Supplementary S2. normal human stem S3. Representative histogram analysis effects cell cycle distribution Table 1: Peritoneal volumes (cm3) treated (n=5 for each group) versus control mice determined at 24-days post-treatment</p>
<div>Abstract<p>Acute myeloid leukemia (AML) is one of the most frequent types blood malignancies. It a complex disorder undifferentiated hematopoietic progenitor cells. The majority patients generally respond to intensive therapy. Nevertheless, relapse major cause death in AML, warranting need for novel treatment strategies. Retinoids have demonstrated potent differentiation and growth regulatory effects normal, transformed, All-<i>trans</i> retinoic acid (ATRA)...