A5026395749- Retinoids in leukemia and cellular processes
- Sesquiterpenes and Asteraceae Studies
- Ubiquitin and proteasome pathways
- Antioxidant Activity and Oxidative Stress
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- T-cell and Retrovirus Studies
- Acute Myeloid Leukemia Research
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Plant Toxicity and Pharmacological Properties
- Nitrogen and Sulfur Effects on Brassica
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Synthesis and Biological Activity
- Nanoplatforms for cancer theranostics
- Bioactive Compounds and Antitumor Agents
- Photodynamic Therapy Research Studies
- Cancer and Skin Lesions
- Sphingolipid Metabolism and Signaling
- Immune Cell Function and Interaction
- Synthetic Organic Chemistry Methods
- Prenatal Screening and Diagnostics
- Nanoparticle-Based Drug Delivery
American University of Beirut
2016-2025
National Cancer Institute
1993-2021
GTx (United States)
2017-2019
Laboratory of Molecular Genetics
2014
National Institutes of Health
1993-2009
Génomes, biologie cellulaire et thérapeutiques
2004
American University of Beirut Medical Center
2004
Thymoquinone (TQ), the most abundant constituent in black seed, was shown to possess potent chemopreventive activities against DMBA-initiated TPA-promoted skin tumors mice. Despite potential interest TQ as a antineoplastic agent, its mechanism of action has not been examined yet. Using primary mouse keratinocytes, papilloma (SP-1) and spindle (I7) carcinoma cells, we studied cellular molecular events involved TQ's activity. We show that non-cytotoxic concentrations reduce proliferation...
To study the contribution of autocrine and paracrine TGF-beta 1 to tumor progression in a well-defined system multistage carcinogenesis, keratinocytes with targeted deletion gene were initiated vitro v-rasHa oncogene their vivo tumorigenic properties determined by skin grafting cells onto athymic mice combination either wild-type or null dermal fibroblasts. Grafts v-rasHa-initiated progressed rapidly multifocal squamous cell carcinomas within dysplastic papillomas irrespective fibroblast...
Research has identified both nonmodifiable and modifiable risk factors for breast cancer (BC), with accumulating evidence showing that adopting adequate dietary practices could decrease the of this disease. This study aimed to assess nutrition knowledge, attitudes, lifestyle (KAP) may lead BC reduction among female university students in Lebanon examine determinants their practices. A cross-sectional survey was conducted using a convenience sampling method, comprising 356 (response rate:...
The high recurrence rates of colorectal cancer have been associated with a small population stem cells (CSCs) that are resistant to the standard chemotherapeutic drug, 5-fluorouracil (5FU). Thymoquinone (TQ) has shown promising antitumor properties on numerous systems both in vitro and vivo; however, its effect CSCs is poorly established. Here, we investigated TQ's potential target three-dimensional (3D) sphere-formation assay enriched for stem/progenitor cells. Our results showed...
The sesquiterpene lactone parthenolide is a major component of the feverfew medicinal plant, Tanacetum parthenium. Parthenolide has been extensively studied for its anti-inflammatory and anticancer properties in several tumor models. Parthenolide's antitumor activities depend on mechanisms but it mainly known as an inhibitor nuclear factor-κB (NF-κB) pathway. This pathway constitutively activated induces cell survival primary effusion lymphoma (PEL), rare aggressive AIDS-related...
Abstract Ultraviolet (UV) B radiation is the most common environmental factor in pathogenesis of skin cancer. Exposure human to UVB leads depletion cutaneous antioxidants, activation nuclear kappa (NF‐κB), and programmed cell death (apoptosis). Although antioxidant supplementation has been shown prevent UVB‐induced photooxidative damage, its effect on components signaling pathways leading gene expression not clearly established. In present study, vitamin, α‐tocopherol (α‐T), acetate analog,...
Despite recent advances in chemotherapy, aggressive and metastatic breast cancers remain refractory to targeted therapy the development of novel drugs is urgently needed. Retinoids are crucial regulators cellular proliferation, differentiation, cell death, have shown potent chemotherapeutic chemopreventive properties. The major drawback use all-trans retinoic acid (ATRA) cancer disease relapse. Therefore, synthetic retinoids, specifically ST1926, emerged as anticancer agents. Given...