A5076005579- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Acute Myeloid Leukemia Research
- Photodynamic Therapy Research Studies
- Sesquiterpenes and Asteraceae Studies
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Nanoparticle-Based Drug Delivery
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Viral-associated cancers and disorders
- Advanced biosensing and bioanalysis techniques
- Lymphoma Diagnosis and Treatment
- Microbial Metabolism and Applications
- Parvovirus B19 Infection Studies
- Vitamin C and Antioxidants Research
- Genomics, phytochemicals, and oxidative stress
- Plant Toxicity and Pharmacological Properties
- Estrogen and related hormone effects
- Coenzyme Q10 studies and effects
- DNA Repair Mechanisms
- Natural product bioactivities and synthesis
- Biological Stains and Phytochemicals
- Glioma Diagnosis and Treatment
American University of Beirut
2017-2025
The sesquiterpene lactone parthenolide is a major component of the feverfew medicinal plant, Tanacetum parthenium. Parthenolide has been extensively studied for its anti-inflammatory and anticancer properties in several tumor models. Parthenolide's antitumor activities depend on mechanisms but it mainly known as an inhibitor nuclear factor-κB (NF-κB) pathway. This pathway constitutively activated induces cell survival primary effusion lymphoma (PEL), rare aggressive AIDS-related...
Colorectal cancer (CRC) is one of the leading cancers and causes death in patients. 5-fluorouracil (5-FU) therapy choice for CRC, but it exhibits high toxicity drug resistance. Tumorigenesis characterized by a deregulated metabolism, which promotes cell growth survival. The pentose phosphate pathway (PPP) required synthesis ribonucleotides regulation reactive oxygen species upregulated CRC. Mannose was recently reported to halt tumor impair PPP. inhibitory effects on are inversely related...
Abstract Retinoids are vitamin A derivatives that regulate crucial biological processes such as cellular proliferation, apoptosis, and differentiation. The use of natural retinoids in cancer therapy is limited due to their toxicity the acquired resistance by cells. Therefore, synthetic were developed, atypical adamantyl retinoid ST1926 provides enhanced bioavailability reduced toxicity. We have assessed vitro vivo antitumor properties mechanism action targeting stem‐like cells population...
Acute myeloid leukemia (AML) is one of the most frequent types blood malignancies. It a complex disorder undifferentiated hematopoietic progenitor cells. The majority patients generally respond to intensive therapy. Nevertheless, relapse major cause death in AML, warranting need for novel treatment strategies. Retinoids have demonstrated potent differentiation and growth regulatory effects normal, transformed, All-trans retinoic acid (ATRA) paradigm acute promyelocytic leukemia, an AML...
Glioblastoma Multiforme (GBM) is the most aggressive form of malignant brain tumor. The median survival rate does not exceed two years, indicating an imminent need to develop novel therapies. atypical adamantyl retinoid ST1926 induces apoptosis and growth inhibition in different cancer types. We have shown that inhibitor catalytic subunit DNA polymerase alpha (POLA1), which involved initiating synthesis eukaryotic cells. POLA1 levels are elevated GBM versus normal tissues. Therefore, we...
Cancer is a major public health problem that ranks as the second leading cause of death. Anti-cancer drug development presents with various hurdles faced throughout process. Nanoparticle (NP) formulations have emerged promising strategy for enhancing delivery efficiency, improving stability, and reducing toxicity. Previous studies shown adamantyl retinoid ST1926 displays potent anti-tumor activities in several types tumors, particularly colorectal cancer (CRC). However, phase I clinical...
<title>Abstract</title> Oxidative stress, a major player in secondary brain injury, has been shown to contribute apoptosis, neuroinflammation, and mitochondrial dysfunction. The possibility of targeting the Nrf2-Keap-ARE pathway, using mitochondria-targeted antioxidants, such as mitoquinone (MitoQ), proposed treat neurotoxicity. neuroprotective effects MitoQ on human neuroblastoma SH-SY5Y cells were assessed by MTT assay, SRB propidium iodide stain at concentrations 0.03 0.05 µg/mL...
Abstract Colorectal cancer is the third most common neoplasia and second cause of cancer-related deaths worldwide. Unlike normal cells, tumor cells reprogram metabolic pathways to meet their bioenergetics, redox, biosynthetic demands rely mostly on aerobic glycolysis (Warburg effect). upregulate pentose phosphate pathway (PPP), p53 a crucial regulator. The PPP significant route for glucose catabolism required DNA synthesis rapidly-proliferating cells. Its oxidative phase (oxPPP), catalyzed...
Several sesquiterpene lactones (STLs) have been tested as lead drugs in cancer clinical trials. Salograviolide-A (Sal-A) and salograviolide-B (Sal-B) are two STLs that isolated from Centaurea ainetensis, an indigenous medicinal plant of the Middle Eastern region. The parent compounds Sal-A Sal-B were modified successfully prepared into eight novel guaianolide-type (compounds 1-8) bearing ester groups different geometries. Sal-A, Sal-B, 1-8 against a human colorectal cell line model with...
<p>Supplementary Figure S1. Effect of ST1926 on the viability AML cells; Supplementary S2. normal human stem S3. Representative histogram analysis effects cell cycle distribution Table 1: Peritoneal volumes (cm3) treated (n=5 for each group) versus control mice determined at 24-days post-treatment</p>
<p>Supplementary Figure S1. Effect of ST1926 on the viability AML cells; Supplementary S2. normal human stem S3. Representative histogram analysis effects cell cycle distribution Table 1: Peritoneal volumes (cm3) treated (n=5 for each group) versus control mice determined at 24-days post-treatment</p>
<div>Abstract<p>Acute myeloid leukemia (AML) is one of the most frequent types blood malignancies. It a complex disorder undifferentiated hematopoietic progenitor cells. The majority patients generally respond to intensive therapy. Nevertheless, relapse major cause death in AML, warranting need for novel treatment strategies. Retinoids have demonstrated potent differentiation and growth regulatory effects normal, transformed, All-<i>trans</i> retinoic acid (ATRA)...
<div>Abstract<p>Acute myeloid leukemia (AML) is one of the most frequent types blood malignancies. It a complex disorder undifferentiated hematopoietic progenitor cells. The majority patients generally respond to intensive therapy. Nevertheless, relapse major cause death in AML, warranting need for novel treatment strategies. Retinoids have demonstrated potent differentiation and growth regulatory effects normal, transformed, All-<i>trans</i> retinoic acid (ATRA)...
Abstract Acute myeloid leukemia (AML) represents one of the most complex types leukemia. It is a clinically and genetically heterogeneous disorder hematopoietic progenitor cells, which have lost their ability to differentiate normally. Retinoids regulate vital biological processes including development, differentiation, proliferation, cell death cells. The natural retinoid all-trans retinoic acid (ATRA) became paradigm for treatment acute promyelocytic (APL), an AML subtype. However, in...