Darío Jacobsen

ORCID: 0000-0002-8082-3538
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About
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Research Areas
  • Stress Responses and Cortisol
  • Adrenal Hormones and Disorders
  • COVID-19 Clinical Research Studies
  • Hair Growth and Disorders
  • Ovarian function and disorders
  • Salivary Gland Disorders and Functions
  • Exercise and Physiological Responses
  • COVID-19 and Mental Health
  • Pituitary Gland Disorders and Treatments
  • Workplace Health and Well-being
  • Collagen: Extraction and Characterization
  • Healthcare professionals’ stress and burnout
  • Adipokines, Inflammation, and Metabolic Diseases
  • Liver Disease Diagnosis and Treatment
  • SARS-CoV-2 and COVID-19 Research
  • Pneumonia and Respiratory Infections
  • SARS-CoV-2 detection and testing
  • Protease and Inhibitor Mechanisms
  • Bacterial Infections and Vaccines
  • melanin and skin pigmentation
  • Tracheal and airway disorders
  • Infrared Thermography in Medicine
  • Dermatology and Skin Diseases
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Connective tissue disorders research

University of Buenos Aires
2015-2024

Instituto de Química y Fisicoquímica Biológicas
2019-2024

Hospital de Clínicas "José de San Martín"
2020-2021

Abstract We present the development of first procedure for hair cortisol measurement through an automated method. Hair samples were obtained from 286 individuals. After extraction, measured in a Siemens Immulite 2000 (Gwynedd, UK) chemoluminiscent immunoassay analyzer. Normal reference values levels 213 healthy individuals with low stress. concentration median was 55 pg/mg (2.5–97.5 percentile (40–128)) stress and 250 (range 182–520) stressed No significant differences observed between...

10.1038/s41598-019-44693-3 article EN cc-by Scientific Reports 2019-06-03

Fil: Repetto, Esteban Martin. Universidad de Buenos Aires. Facultad Farmacia y Bioquimica. Departamento Bioquimica Clinica; Argentina. Consejo Nacional Investigaciones Cientificas Tecnicas; Argentina

10.1515/cclm-2016-0585 article ES Clinical Chemistry and Laboratory Medicine (CCLM) 2017-01-01

The aim of the study was to evaluate adrenal axis hyperactivation measuring hair cortisol levels, and its influence on relationship among metabolic parameters, inflammation markers androgens in adult women with PCOS. 44 (18-34 years) PCOS diagnosis a control group 49 healthy (19-35 were included. In both gropus body mass index (BMI) calculated waist circumference (WC) measured. Hair cortisol, total serum testosterone (TT), 25 OH vitamin D (25OHD), insulin, high sensitivity C-reactive protein...

10.1038/s41598-022-14061-9 article EN cc-by Scientific Reports 2022-06-20

Coronavirus disease-19 (COVID-19) patients with severe complications present comorbidities like cardiovascular-disease, hypertension and type-2 diabetes mellitus (DM), sharing metabolic alterations insulin resistance (IR) dyslipidemia. Our objective was to evaluate the association among different components of lipid-lipoprotein profile, such as remnant lipoprotein (RLP)-cholesterol, in COVID-19, analyze their associations severity disease death. We studied 193 (68 (29-96) years; 49.7% male)...

10.1038/s41598-022-21177-5 article EN cc-by Scientific Reports 2022-10-20

Abstract This study evaluates the impact of COVID-19 pandemic on healthcare workers in Argentina, during second wave 2021. The aim is to assess stress, burnout, and anxiety levels, incorporating assessment hair cortisol levels as a biomarker chronic stress. A total 496 from three different hospitals were included this study. Two these depend Buenos Aires City Ministry Health third hospital belongs University. Hair samples obtained using scissors posterior vertex, close scalp possible. Each...

10.21203/rs.3.rs-4075574/v1 preprint EN cc-by Research Square (Research Square) 2024-03-29

Introducción: la meningitis bacteriana postneuroquirúrgica (MBPN) presenta alta mortalidad. El diagnóstico rápido es esencial. método de referencia el cultivo del líquido cefalorraquídeo (LCR), pero requiere tiempo, utilizándose antibióticos empíricos innecesarios, importante evaluar otros parámetros que permitan una detección temprana. Objetivos: utilidad lactato en LCR como marcador temprano MBPN, determinar su punto corte nuestra población y correlacionar valores con proteinorraquia...

10.59156/revista.v38i04.678 article ES Revista Argentina de Neurocirugía 2024-12-01

Objectives — The objective of our study was to assess humoral response in a population health workers after vaccination with the first and second doses Sputnik V. Methods SARS-CoV-2 total antibodies (IgG IgM) were measured, using Centaur XPT autoanalyzer, Siemens®, 530 serum samples taken from Buenos Aires vaccinated Results After 21 days dose application, 10 individuals (1.9%) presented antibody levels <1.0 (non-reactive), while 520 subjects (98.1%) responded values >1.0 (reactive)....

10.15275/rusomj.2023.0102 article EN cc-by-nc Russian Open Medical Journal 2023-03-28

Abstract INTRODUCTION: Oocyte number and quality are known to decline with age. However, fertility varies significantly even among women of the same Given that maternal age has been delayed in recent years, an ovarian biomarker could reflect follicular activity precision accuracy is needed reproductive medicine. In two key methods, concentration serum antimüllerian hormone (AMH), which reflects small antral follicles predictive response, follicle count (AFC) performed by ultrasonography,...

10.1210/jendso/bvaa046.1362 article EN cc-by-nc-nd Journal of the Endocrine Society 2020-04-01

Abstract Diagnosis of endogenous Cushing’s syndrome entails corticotropic autonomy, lack circadian rhythm and/or hypercortisolism, evaluated through 24h urinary free cortisol (UFC). Hair measurement (HCM) has been described as an alternative marker exposure over the preceding three months. OBJECTIVES To evaluate HCM in disease (CD). analyze correlation between and UFC. compare values CD vs controls. PATIENTS AND METHODS 3 cm hair from posterior vertex controls age- gender-matched May 2017...

10.1210/jendso/bvaa046.597 article EN cc-by-nc-nd Journal of the Endocrine Society 2020-04-01
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