A5052673283- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Analytical Methods in Pharmaceuticals
- Galectins and Cancer Biology
- Diabetes Management and Research
- Ion Transport and Channel Regulation
- Advanced Statistical Process Monitoring
- Lysosomal Storage Disorders Research
- Exercise and Physiological Responses
- Sphingolipid Metabolism and Signaling
- Rural and Ethnic Education
- Dermatology and Skin Diseases
- Education and Digital Technologies
- SARS-CoV-2 and COVID-19 Research
- Cellular transport and secretion
- Pharmaceutical studies and practices
- Synthesis and biological activity
- ATP Synthase and ATPases Research
- Erythrocyte Function and Pathophysiology
- Venomous Animal Envenomation and Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Drug Transport and Resistance Mechanisms
- Amphibian and Reptile Biology
- Synthesis and Biological Evaluation
- Genomics and Phylogenetic Studies
Florida International University
2023-2024
Instituto de Química y Fisicoquímica Biológicas
2014-2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2021
University of Buenos Aires
2014-2021
Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro
2016
Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there a clinical need to develop more effective drugs fewer adverse reactions. Chalcones one of the major classes naturally occurring compounds. their derivatives have huge importance in medicinal chemistry, displaying wide range pharmacological activities including anti-inflammatory, antimicrobial, antioxidant, cytotoxic antitumor actions. The aim...
Abstract We present the development of first procedure for hair cortisol measurement through an automated method. Hair samples were obtained from 286 individuals. After extraction, measured in a Siemens Immulite 2000 (Gwynedd, UK) chemoluminiscent immunoassay analyzer. Normal reference values levels 213 healthy individuals with low stress. concentration median was 55 pg/mg (2.5–97.5 percentile (40–128)) stress and 250 (range 182–520) stressed No significant differences observed between...
Fc γ-receptors (FcγRs) on leukocytes bind immunoglobulin G (IgG) immune complexes to mediate effector functions. Dysregulation of FcγR-mediated processes contributes multiple inflammatory diseases, including rheumatoid arthritis, lupus, and thrombocytopenia. Critically, immunoregulatory N-glycan modifications both FcγRs IgGs alter FcγR-IgG binding affinity. Rapid methods for the characterization N-glycans across Fcγ receptors are needed propel investigations into disease-specific...
Ceramides (Cers) and complex sphingolipids with defined acyl chain lengths play important roles in numerous cell processes. Six Cer synthase (CerS) isoenzymes (CerS1–6) are the key enzymes responsible for production of diversity molecular species. In this study, we investigated changes sphingolipid metabolism during differentiation Madin-Darby canine kidney (MDCK) cells. By MALDI TOF MS, analyzed species Cer, glucosylceramide (GlcCer), lactosylceramide (LacCer), SM nondifferentiated...
Fcγ-receptors (FcγRs) including FcγRII (CD32) gene family members are expressed on leukocytes, bind the crystallizable fragment (Fc) region of immunoglobulin G (IgG), and bridge humoral cellular immunity. FcγRIIA FcγRIIB have opposing roles, with former responsible for activation latter inhibition immune cell signaling effector functions. The extracellular domains human murine FcγRIIs share multiple conserved
Mucin-domain glycoproteins expressed on cancer cell surfaces play central roles in adhesion, progression, stem renewal, and immune evasion. Despite abundant evidence that mucin-domain are critical to the pathobiology of head neck squamous carcinoma (HNSCC), our knowledge composition mucinome is grossly incomplete. Here, we utilized a catalytically inactive point mutant enzyme StcE (StcEE447D) capture line lysates followed by their characterization using sodium dodecyl-sulfate polyacrylamide...
The yeast Spf1p protein is a primary transporter that belongs to group 5 of the large family P-ATPases. Loss function produces ER stress with alterations metal ion and sterol homeostasis folding, glycosylation membrane insertion. amino acid sequence shows characteristic P-ATPase domains A, N, P transmembrane segments M1-M10. In addition, exhibits unique structures at its N-terminus (N-T region), including two putative additional domains, insertion connecting domain segment M5 (D region)....
Abstract Since the discovery of SARS-CoV-2, several antigens have been proposed to be part COVID-19 vaccines. The receptor binding domain (RBD) Spike protein is one promising candidates develop effective vaccines since it can induce potent neutralizing antibodies. We previously reported production RBD in Pichia pastoris and showed structurally identical produced mammalian HEK-293T cells. In this work we designed an multimer construct with purpose increasing immunogenicity. multimeric...
If one knows the probability of an event occurring in a population, Bayesian statistics allows modifying its value when there is new individual information available. Although and frequentist (classical) methodologies have identical fields application, first increasingly applied scientific research big data analysis. In modern pharmacotherapy, clinical pharmacokinetics has been used for expansion monitoring, facilitated by technical-analytical mathematical-statistical developments....
La metodología estadística Bayesiana permite, si se conoce la probabilidad poblacional de que un suceso ocurra, modificar su valor cuando dispone nueva información individual. Aunque las metodologías y frecuentista (clásica) tienen idénticos campos aplicación, primera aplica cada vez más en investigación científica análisis big data. En farmacoterapia moderna, farmacocinética clínica ha sido responsable expansión monitorización, facilitada por desarrollos técnico-analíticos...
Esse trabalho relata o projeto de extensão Aprender e Ensinardo IFTM Campus Campina Verde. O objetivo inicial do era colaborar com a redução da exclusão digital no meio rural, oferecendo um curso básico Informática alunos uma escola na zona rural participação Curso Técnico em IFTM. Porém, decorrer as necessidades observadas levaram mudança metodologia que passou seguir modelo diferente dos convencionais; orientado ao protagonismo alunos, baseado nos conceitos educação tecnológica...
La metodología estadística Bayesiana permite, si se conoce la probabilidad poblacional de que un suceso ocurra, modificar su valor cuando dispone nueva información individual. Aunque las metodologías y frecuentista (clásica) tienen idénticos campos aplicación, primera aplica cada vez más en investigación científica análisis big data. En farmacoterapia moderna, farmacocinética clínica ha sido responsable expansión monitorización, facilitada por desarrollos técnico-analíticos...