A5101632376- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Bioinformatics and Genomic Networks
- Ureteral procedures and complications
- Peptidase Inhibition and Analysis
- Nuclear Receptors and Signaling
- Ginkgo biloba and Cashew Applications
- Central Venous Catheters and Hemodialysis
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Heavy Metals in Plants
- Circular RNAs in diseases
- Graphene and Nanomaterials Applications
- Nephrotoxicity and Medicinal Plants
- Cancer Immunotherapy and Biomarkers
Peking University
2021-2024
Xintai People's Hospital
2022-2023
National Sun Yat-sen University
2023
Shanghai Ninth People's Hospital
2017-2022
Shanghai Jiao Tong University
2017-2022
National Clinical Research Center for Digestive Diseases
2021-2022
National Pingtung University
2018
Abstract Background Invasive malignant pleomorphic adenoma (IMPA) is a highly invasive parotid gland tumor and lacks effective therapy. N6-Methyladenosine (m 6 A) the most prevalent post-transcriptional modification of mRNAs in eukaryotes plays an important role pathogenesis multiple tumors. However, significance m A-modified IMPA has not been elucidated to date. Hence, this study, we attempted profile effect terms A methylation mRNA. Methods Methylated RNA immunoprecipitation with...
5-Methylcytosine (m 5 C) methylation is a major epigenetic technique of RNA modification and dynamically mediated by m C “writers,” “erasers,” “readers.” its regulators are implicated in the onset development many tumors, but their roles head neck squamous cell carcinoma (HNSCC) have not yet been completely elucidated. In this study, we examined expression patterns core publicly available HNSCC cohort via bioinformatic methods. The differentially expressed could divide into four subgroups...
Abstract Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) subgrouped into four distinct molecular subtypes. This study aimed to identify potential gene related glioma progression. Weighted co‐expression network analysis (WGCNA) was used explore gene. Correlation, ROC, survival Cox regression analyses were performed. Blue module strongly associated with WHO grade ( r = .65, P 1e‐19). GNG5 in gliomas overexpressed compared normal samples clinicopathologic...
Angiogenesis is extensively involved in embryonic development and requires complex regulation networks, whose defects can cause a variety of vascular abnormalities. Cis-regulatory elements control gene expression at all developmental stages, but they have not been studied or profiled angiogenesis yet. In this study, we exploited public DNase-seq RNA-seq datasets from VEGFA-stimulated vitro angiogenic model, carried out an integrated analysis the transcriptome chromatin accessibility across...
Abstract Background Invasive malignant pleomorphic adenoma (IMPA) is a highly neoplasm of the oral salivary glands with poor prognosis and considerable risk recurrence. Many disease-causing genes IMPA have been identified in recent decades (e.g., P53, PCNA HMGA2), but many these remain to be explored. Weighted gene coexpression network analysis (WGCNA) newly emerged algorithm that can cluster form modules based on similar expression patterns. This study constructed via WGCNA then carried out...
Gliomas are the most malignant central nervous system tumors. With development of sequencing technology, more potential biomarkers related to treatment, prognosis, and molecular classification glioma have been identified. Here, we intend investigate biological function clinical value a new biomarker in glioma.KDELR1 expression data corresponding information were downloaded from public databases then preprocessed using R language. Correlation, Kaplan-Meier survival, Cox regression analyses...
Objectives: Gliomas remain one of serious public health problems worldwide which demand further and deeper investigation. The aim this study was to explore the association between synapse defective protein 1 homolog ( SYDE1 ) gliomas via database analysis in vitro validation determine potential diagnostic prognostic values. Methods Results: Compared with healthy brain tissues, there a significant increase expression glioma tissues. Additionally, exhibited higher levels patients unfavorable...
VSD combined with other cardiac or extracardiac malformations (defined as "complex VSD" by us) is one of the major causes perinatal morbidity and mortality. Functional non-coding SNPs (cis-regulatory SNPs) have not been systematically studied in CHDs, including complex VSD. Here we report an exome-wide association analysis using WES data 60 PA/VSD cases, 20 TOF cases 100 controls Chinese children. We identify 93 low-frequency associated risk. A functional genomics pipeline integrating...