A5101930227- Maternal and Perinatal Health Interventions
- Kruppel-like factors research
- Venous Thromboembolism Diagnosis and Management
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Adrenal Hormones and Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Atrial Fibrillation Management and Outcomes
- Epigenetics and DNA Methylation
- Cardiac Arrhythmias and Treatments
- RNA modifications and cancer
- Clostridium difficile and Clostridium perfringens research
- Parathyroid Disorders and Treatments
- Pregnancy-related medical research
- Renal and related cancers
- Prenatal Substance Exposure Effects
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Growth Hormone and Insulin-like Growth Factors
- Intensive Care Unit Cognitive Disorders
- Retinoids in leukemia and cellular processes
University of Louisville
2022-2023
University of Missouri–Kansas City
2023
Saint Luke's Hospital
2023
American Heart Institute
2023
National Institutes of Health
2017-2021
National Cancer Institute
2017-2021
Center for Cancer Research
2017-2021
Regenerative Medicine Institute
2011
Thomas Jefferson University
2010-2011
Sidney Kimmel Cancer Center
2011
Breast cancer progression and metastasis are driven by complex reciprocal interactions, between epithelial cells their surrounding stromal microenvironment. We have previously shown that a loss of Cav-1 expression is associated with an increased risk early tumor recurrence, decreased overall survival. To identify characterize the signaling pathways activated in negative stroma, we performed gene profiling using laser microdissected breast cancer-associated stroma. Tumor stroma was capture...
Background : Following catheter ablation, vascular access management involves potential complications and prolonged recovery. Recently, suture mediated closure (SMC) devices were approved for venous procedures. Objective: Evaluate the safety of a commercially available SMC multiple site by DUS in asymptomatic subjects with non-visible complications. Methods 36 (63 + 10.7 years old, 12 female) enrolled. ablation atrial fibrillation, all had every site. Subjects underwent femoral veins...
Abstract Introduction: The retinoblastoma tumor suppressor gene (RB), initially identified in the pediatric retinoblastoma, has been shown to be functionally inactivated a variety of other types. RB functions as key regulator cell cycle progression and modulates response physiological clinically relevant stresses. In breast cancer, loss have prognostic significance influence therapeutic response; however, comprehensive analyses triple negative cancer (TNBC) not performed. Although TNBC...
Abstract An increasing number of women are diagnosed with ductal carcinoma in situ (DCIS). DCIS is non-obligate precursor to invasive breast cancer. Mechanisms leading development and progression cancer (IBC) still largely unknown. When IBC coexist the same lesion, their transcriptional profiles nearly identical; however, there very few studies investigating gene expression pure DCIS. The goal this study was compare microdissected epithelial stromal components IBC. Epithelium stroma were...
Abstract Breast cancer growth and progression are governed by complex reciprocal interactions between tumor cells surrounding stromal elements. We have previously shown that a loss of Cav-1 expression is associated with an increased risk early recurrence, metastasis decreased overall survival. To identify characterize the signaling pathways activated in negative stroma, we performed gene profiling using laser micro-dissected breast stroma. Methods: Tumor stroma was capture Leica LCM system...
Abstract Insulin-like growth factor receptor 1 (IGF-1R) has a key regulatory role in malignancy and is the target of several drugs currently tested clinical trials. Few studies have shown that IGF-IR expression associated with estrogen positive breast cancer. However, there are no systematic IGF1R triple negative carcinoma (TNBC). The aim this study was to evaluate protein gene amplification TNBC. Material Methods: Ninety-seven TNBC (73 from Caucasian 24 African American women) were stained...
Abstract Metastasis causes most cancer deaths, and new therapies that are based on a deeper understanding of this process required to improve patient survival. Metastatic tumor cell colonization growth is facilitated by pre-metastatic niche microenvironment composed hematopoietic cells, stromal extracellular matrix support survival growth. Perivascular including vascular smooth muscle cells (vSMCs) pericytes, key population involved in vessel formation critical primary development. Given the...
INTRODUCTION: Prepregnancy obesity is reaching epidemic proportions in the United States. Maternal alone not an indication for induction of labor (IOL). Recent studies have shown that elective IOL >39 weeks does increase cesarean delivery (CD) rates; however, patients with severe (BMI >40) are represented many these trials, creating a gap our ability to provide patient-centered care. METHODS: A retrospective chart review BMI >40 between May 2016 and December 2020 at single...