A5031847808- Bone health and treatments
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Autophagy in Disease and Therapy
- Magnesium in Health and Disease
- HIV-related health complications and treatments
- Body Composition Measurement Techniques
- Advanced Glycation End Products research
- Bone and Joint Diseases
- Diet and metabolism studies
- Nutrition and Health in Aging
- TGF-β signaling in diseases
- Gut microbiota and health
- Extracellular vesicles in disease
- Mesenchymal stem cell research
Wuxi People's Hospital
2025
Nanjing Medical University
2025
Southwest Medical University
2025
People's Liberation Army 411 Hospital
2016
Helen Hayes Hospital
2002-2014
American Society of Nephrology
2013
New York State Department of Health
2002-2005
United States Bone and Joint Initiative
2005
Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells responsible for bone formation, osteoclasts (OC), specialized resorption, and osteocytes, multifunctional mechanosensing embedded matrix, are main actors. Increased oxidative stress OB, producing mineralizing has been associated with osteoporosis development but role of autophagy OB not yet addressed. This goal present study. We first show that autophagic process induced during mineralization. Then, using...
Abstract The cellular and molecular events triggering the anabolic response of skeleton to exogenous parathyroid hormone (PTH) are not well understood. Despite numerous bone mass studies in rats, few data available for mice. Therefore, we treated 10-week-old female intact C57BL/6J mice with human PTH(1-34) delivered subcutaneously at a dose 40 μg/kg per day 5 days week 3 weeks 7 weeks. Bone mineral density (BMD) total bone, femur, tibia, lumbar vertebrae was measured weekly by PIXImus....
Abstract The prevailing view for many years has been that osteoclasts do not express parathyroid hormone (PTH) receptors and PTH's effects on are mediated indirectly via osteoblasts. However, several recent reports suggest PTH receptors. In this study, we tested the hypothesis human formed in vitro functional type 1 (PTH1R). Peripheral blood monocytes (PBMC) were cultured bone slices or plastic culture dishes with recombinant RANK ligand (RANKL) macrophage colony‐stimulating factor (M‐CSF)...
The elderly population is prone to osteoporosis, owing the deterioration of skin, liver, and kidney functions. Vitamin D (VD) supplementation has a limited effect, VD deficiency mostly treated with medication. Several studies have shown that gut microbiota alters intestinal metabolism probiotic supplements can influence circulating levels. Therefore, in present study, we screened strain Bifidobacterium longum FSHHK13M1 increase level metabolites fermented supernatant species vitro by...
Advanced glycation end products (AGEs) contribute to the onset and advancement of diabetic osteoporosis (DOP). Adipose-derived stem cells (ASCs) have garnered attention in field bone renewal; mechanisms leading decreased osteogenesis within a environment are not fully understood. This study explores effects/molecular pathways AGEs on ASCs both vitro vivo. A DOP mouse model was used, were extracted from inguinal fat C57BL/6 mice. cultivated an osteogenic differentiation medium exposed AGEs,...
Parathyroid hormone (PTH) stimulates bone resorption as well formation in vivo and organ culture. The catabolic actions of PTH have been recognized patients with hyperparathyroidism, or acute infusion the N-terminal 1-34 fragment human (hPTH1-34). Whereas anabolic daily injection studied both humans mice, on murine remain to be defined. To do this we sought create a model short-term, sustained hyperparathyroidism using osmotic pumps. We treated 10-week-old female C57BL/J6 mice continuous...
Abstract We developed a cyclic PTH regimen with repeated cycles of 1-week on and off daily injection explored its effects bone strength, BMD, markers, structure in mice. Cyclic protocols produced 60–85% the achieved by 57% total given, indicating more economic use PTH. The study supports further exploration regimens for treatment osteoporosis. Introduction: To minimize cost catabolic action hPTH(1-34), 3-month on-and-off hPTH(1-34) was humans shown to be as effective increasing vertebral...
Background An accelerated muscle wasting was the pivotal factor for protein-energy in end stage renal disease. However, very few researches have examined skeletal quantity and quality clinical patients. This study investigated morphologic changes by magnetic resonance imaging (MRI) analyzed related factors hemodialysis Methods Fifty-eight patients receiving maintenance (HD) were 28 healthy adults with gender age matched used as controls (Control). Anthropometry, cytokine factors, laboratory...
Epidemiologic studies have linked low dietary magnesium (Mg) intake to osteoporosis. Dietary Mg restriction in animal models has demonstrated a decrease bone mass and an increase skeletal fragility. The exact mechanism for the is not clear but osteoblast number osteoclast (Oc.No/B.Pm) suggests uncoupling of formation resorption favoring loss. depletion results inflammatory cytokines, which could explain resorption. We previously TNFα from deficient rodents. Here we report 3 week study (LM)...
Tonifying Shen strategy works as an important alternative and complementary method that is widely used to treat osteoporosis in Traditional Chinese Medicine (TCM) based on the proper identification of Zheng. deficiency Zheng one main types while Shen-Yin -Yang deficiencies represent two basic principles/types deficiency. Currently, strategy, particular, principles, has been demonstrated exert osteoprotective effects. However, mechanisms by which and/or principles function treating are still...