A5076987385- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Immunotherapy and Immune Responses
- Trace Elements in Health
- PARP inhibition in cancer therapy
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Immune cells in cancer
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Genomics and Chromatin Dynamics
- Intraperitoneal and Appendiceal Malignancies
- Nutrition, Genetics, and Disease
- Pluripotent Stem Cells Research
- Phagocytosis and Immune Regulation
- Congenital heart defects research
- Histone Deacetylase Inhibitors Research
- Barrier Structure and Function Studies
- Insect Resistance and Genetics
RMIT University
2019-2024
Universitas Nusa Bangsa
2021
University of California, Los Angeles
2013
Radboud University Nijmegen
2007-2010
Radboud University Medical Center
2007-2010
University Medical Center Utrecht
2004-2008
Utrecht University
2005
Cell-fate decisions and pluripotency are dependent on networks of key transcriptional regulators. Recent reports demonstrated additional functions pluripotency-associated factors during early lineage commitment. The T-box transcription factor TBX3 has been implicated in regulating embryonic stem cell self-renewal cardiogenesis. Here, we show that is dynamically expressed specification the mesendoderm lineages differentiating cells (ESCs) vitro developing mouse Xenopus embryos vivo. Forced...
Nontransferrin-bound iron (NTBI) has been detected in overload diseases. This form of may exert pro-oxidant effects and modulate cellular function inflammatory response. The present study aimed to investigate the serum NTBI on monocyte adherence endothelium. Measured by a recently developed high-throughput fluorescence-based assay, was found be higher both homozygotes HFE C282Y mutation hereditary hemochromatosis (7.9+/-0.6 microM, n=9, P<0.001) heterozygotes (4.0+/-0.5 n=8, P<0.001),...
Elevated iron stores and high plasma concentration have been linked to an increased risk of atherosclerosis. Iron may thereby affect the interaction monocytes endothelium, initial event in formation atherosclerotic plaques.Addition 10 mumol/L non-transferrin-bound incubation medium caused a 2-fold increase monocyte adhesion human umbilical vein endothelial cells (HUVECs). A concordant expression following molecules was observed: vascular cell molecule-1, intercellular selectin on HUVECs as...
Heme oxygenase-1 (HO-1) contribution to iron homeostasis has been postulated, because it facilitates recycling by liberating mostly from heme catabolism. This enzyme also appears be responsible for the resolution of inflammatory conditions. In a patient with HO-1 deficiency, inflammation and dysregulation body homeostasis, including anemia liver kidney hemosiderosis, are evidenced. Here we postulated that is critical in regulation ferroportin, major cellular exporter, hepcidin, key regulator...
We hypothesised that the inclusion of immunosuppressive and inflammatory biomarkers in HGSOC patients would improve sensitivity specificity preoperative marker prediction malignancy with ovarian masses. tested a panel 29 soluble immune factors by multiplex bead immunoassay 16 phenotypic T cell markers flow cytometry pre-treatment blood samples from 66 undergoing surgery for suspected cancer or risk reduction. The potential diagnostic utility all parameters was explored using Volcano plots,...
Abstract Background Chronic inflammation has been implemented in the pathogenesis of inflammatory diseases like atherosclerosis. Several pathogens Chlamydia pneumoniae (Cp) and cytomegalovirus (CMV) result thereby are potentially artherogenic. Those infections could trigger endothelial activation, starting point atherogenic cascade. Considering role iron a wide range infection processes, presence may complicate infection‐mediated activation. Materials methods Endothelial intercellular...
There is a correction concerning an author name of article published in previous issue the Journal Cellular and Molecular Medicine[1]. The corresponding last was as Dorine W. Winkels. This corrected to Swinkels. We apologise for this error.