A5101822739- Congenital heart defects research
- Wnt/β-catenin signaling in development and cancer
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Nitric Oxide and Endothelin Effects
- Facial Trauma and Fracture Management
- Neuroblastoma Research and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Heat shock proteins research
- Ultrasound and Hyperthermia Applications
- Sesame and Sesamin Research
- Brain Metastases and Treatment
- Hippo pathway signaling and YAP/TAZ
- Redox biology and oxidative stress
- Dupuytren's Contracture and Treatments
- Cardiac Fibrosis and Remodeling
Universität Ulm
2011-2019
Dongyang People's Hospital
2016-2018
Wenzhou Medical University
2016-2018
City of Hope
2018
University of Missouri–Kansas City
2017
Children's Mercy Hospital
2017
Shantou University
2005-2013
Huazhong University of Science and Technology
2010-2013
Second Affiliated Hospital of Shantou University Medical College
2005-2013
During cardiogenesis, most myocytes arise from cardiac progenitors expressing the transcription factors Isl1 and Nkx2-5. Here, we show that a direct repression of by Nkx2-5 is necessary for proper development ventricular myocardial lineage. Overexpression in mouse embryonic stem cells (ESCs) delayed specification inhibited expression its downstream targets Isl1(+) precursors. Embryos deficient lineage failed to downregulate protein cardiomyocytes heart tube. We demonstrated directly binds an...
Cell-fate decisions and pluripotency are dependent on networks of key transcriptional regulators. Recent reports demonstrated additional functions pluripotency-associated factors during early lineage commitment. The T-box transcription factor TBX3 has been implicated in regulating embryonic stem cell self-renewal cardiogenesis. Here, we show that is dynamically expressed specification the mesendoderm lineages differentiating cells (ESCs) vitro developing mouse Xenopus embryos vivo. Forced...
The object of this study was to compare the effects and complications manual computer-aided shaping titanium meshes for repairing large frontotemporoparietal skull defects following traumatic brain injury.From March 2005 June 2011, 161 patients with were observed. Patients divided into 2 groups according repair materials used cranioplasty: 83 cases mesh, whereas remaining 78 a manually shaped mesh. advantages disadvantages methods compared.No case mesh loosening occurred in either group....
Abstract Background Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. Methods We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) in 88 patients with 41 high-grade gliomas 47 low-grade gliomas. Intratumoral microvessel density (IMD) was also determined associated clinicopathological factors. Results...
The family of vertebrate Mef2 transcription factors is comprised four members named Mef2a, Mef2b, Mef2c, and Mef2d. These are regulators the myogenic programs with crucial roles in development skeletal, cardiac smooth muscle cells. Mef2a Mef2c essential for mice. In Xenopus, mef2c mef2d but not mef2a were recently shown to be expressed during cardiogenesis. We here investigated function Mef2d Xenopus laevis Knocking down either gene by corresponding antisense morpholino oligonucleotides led...
Wnt proteins can activate different intracellular signaling pathways. These pathways need to be tightly regulated for proper cardiogenesis. The canonical Wnt/β-catenin inhibitor Dkk1 has been shown sufficient trigger cardiogenesis in gain-of-function experiments performed multiple model systems. Loss-of-function studies however did not reveal any fundamental function during Using Xenopus laevis as a we here show the first time that is required differentiation of cardiomyocytes, whereas...
Abstract Emerging evidence support an important role of reactive oxygen species in various forms insulin resistance. It is identified that melatonin has antioxidant properties and prevents toxic effects species. In this study, we sought to assess the involvement progression resistance response a high-fat diet (HFD) investigate underlying mechanisms. Male rats were fed with control diet, or supplemented (5 mg kg−1, i.p.) for 10 weeks. Glucose homeostasis, sensitivity, antioxidative potency,...
MicroRNA-425 promotes the development of lung adenocarcinoma via targeting A disintegrin and metalloproteinases 9 (ADAM9) Ruibao Liu, Fang Wang, Yanchun Guo, Jianmei Yang, Shaoping Chen, Xin Gao, Xunguo Wang Department Oncology, Dongying People's Hospital, Dongying, Shandong 257091, Republic China Purpose: We aimed to investigate roles microRNA-425 (miR-425) in adenocarcinoma, as well its possible regulatory mechanism.Materials methods: The miR-425 expression tissues cells was determined....
To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well expression of heat shock protein 70 (HSP70) with hypoxic encephalopathy (HIE).Twenty four 3 day old were permanently ligated common carotid arteries bilaterally ventilated 3% oxygen for 30 minutes, their brains examined at three hours, six 24 hours after ischaemia T2 images images. Apparent coefficient (ADC) values measured HSP70 was detected central peripheral regions...
This study aimed to compare the therapeutic efficacy and side effects of different endostar administration methods in patients with advanced malignancy who underwent second-line chemotherapy.98 malignancies were divided into 2 groups based on delivery endostar, including drip intravenous (DE) group continuous (CE) group. Response rate (RR), disease control (DCR), quality life (QOL) examined evaluate efficacy, toxicity reactions analyzed adverse effects.Compared DE group, CE has been slightly...