A5032968932- Bone Tissue Engineering Materials
- Collagen: Extraction and Characterization
- Dental materials and restorations
- biodegradable polymer synthesis and properties
- Glass properties and applications
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Bone and Dental Protein Studies
- Orthopaedic implants and arthroplasty
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
- Luminescence Properties of Advanced Materials
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Tendon Structure and Treatment
- Cellular Mechanics and Interactions
- Dental Erosion and Treatment
- Knee injuries and reconstruction techniques
- Facial Trauma and Fracture Management
- Surgical Sutures and Adhesives
- Blood properties and coagulation
- Orthodontics and Dentofacial Orthopedics
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
McGill University
2015-2024
University College London
2002-2010
Eastman Dental Hospital
2002-2010
Friedrich-Alexander-Universität Erlangen-Nürnberg
2010
Gray's Inn
2006-2007
Swiss Federal Laboratories for Materials Science and Technology
2007
Imperial College London
2006-2007
University of Westminster
2007
University of Southampton
2007
UCL Australia
2005-2006
Abstract Currently, the concept of engineered tissues depends on ability cultured cells to fabricate new tissue around a scaffold. This is inherently slow and expensive has had limited success so far. We report here process for cell‐independent, controlled engineering biomimetic scaffolds by rapid removal fluid from hyperhydrated collagen gel (or other) constructs, using plastic compression (PC). PC fabrication produces dense, cellular, mechanically strong native structures with controllable...
Bioactive glasses have long been investigated in mineralized tissue regeneration, but recently their potential applications soft repair, and particular wound healing, demonstrated great promise. Commonly used glasses, such as the silicate-based Bioglass® 45S5 [(46.1)SiO2-(26.9)CaO-(24.4)Na2O-(2.6)P2O5 (mol%)] borate-based 13-93B3 [(54)B2O3-(22)CaO-(6)Na2O-(8)K2O-(8)MgO-(2)P2O5 implicated stages of healing due to ability release ions that can stimulate processes, haemostasis, antibacterial...
Collagen gel is a poroelastic/biphasic system consisting of fibrillar loose lattice structure filled with >99% fluid. Its mechanical behaviour governed by the inherent viscoelasticity fibrils, and their interaction This study investigated underlying mechanisms plastic compression (PC), recently introduced technique for production dense collagen matrices tissue engineering. Unconfined compressive loading results in rapid expulsion fluid phase to produce scaffolds improved properties...
Abstract Therapies using mesenchymal stem cell (MSC) seeded scaffolds may be applicable to various fields of regenerative medicine, including craniomaxillofacial surgery. Plastic compression collagen with MSC has been shown enhance the osteogenic differentiation as it increases fibrillary density. The aim present study was evaluate effects dense gel dental pulp cells (DPSC) on bone regeneration in a rat critical-size calvarial defect model. Two symmetrical full-thickness defects were created...
Scaffolds for bone tissue engineering must meet a number of requirements such as biocompatibility, osteoconductivity, osteoinductivity, biodegradability, and appropriate biomechanical properties. A combination type I collagen 45S5 Bioglass may these requirements, however, little has been demonstrated on the effect potential nanofibrillar three-dimensional mineralization its influence structural mechanical properties scaffolds. In this work, rapidly fabricated dense collagen−Bioglass hybrid...
Porous bioactive glass‐ceramics based on the 45S5 Bioglass ® composition were fabricated by an acid‐catalyzed sol–gel method. The effects of aging time and temperature structure in vitro bioactivity investigated. Fourier‐transform infrared spectroscopy ( FTIR ) was carried out samples to understand monitor formation hydroxyapatite HA after immersion simulated body fluid SBF ). gel‐derived glass‐ceramic amorphous compared. results showed that increase both can enhance crystallization, whereas...
Attributable to their low chemical durability, borate-based glasses have been demonstrated convert rapidly hydroxy-carbonated apatite (HCA), the inorganic component of bone. However, effect sol-gel processing on bioactivity has not investigated. In this study, gel and glass forming abilities six different formulations with borate content ranging from 36 61 mol % based a previously studied four melt-derived system [(46.1)B2O3–(26.9)CaO–(24.4)Na2O–(2.6)P2O5; %] were Compared melt-quench,...
Plastic compression of hyperhydrated collagen gels produces tissue-like scaffolds enhanced biomechanical properties. By increasing density, these could be developed into highly Biomimetic cell-seeded templates. When utilizing three-dimensional (3-D) scaffold systems for tissue repair, and indeed when investigating the cytocompatibility two-dimensional (2-D) surfaces, cell seeding density is often overlooked. In this study, we investigated potentially critical parameter using MG-63 cells...
A problem with tissue engineering scaffolds is maintaining seeded cell viability and function due to limitations of oxygen nutrient transfer. An approach maintain suitable concentrations throughout the scaffold would be controllably incorporate microchannelling within these scaffolds. This study investigated incorporation unidirectionally aligned soluble phosphate based glass fibers (PGF) into dense collagen PGF are degradable, their degradation can controlled through chemistry dimensions....
The ability of a silver-doped bioactive glass (AgBG) coating to prevent bacterial colonization on surgical sutures was investigated in vitro. Bioactive powders, the form 45S5 Bioglass and AgBG, were used coat Mersilk using an optimized 'in house' slurry-dipping process. In vitro experiments carried out Staphylococcus epidermidis under both batch flow conditions. While traditional culture testing determine number viable cells adhered surface, flow-cell visualize attachment detachment over...
Abstract The thermo‐mechanical analysis of some novel, totally bioactive, three‐component composite systems intended for the repair and augmentation bone has been performed. composites are composed hydroxyapatite (HA), particulate reinforced biodegradable polylactic acid (PDLLA), with a second reinforcing phase semi‐crystalline, unidirectional fibers (PLLA) homopolymer. Dynamic mechanical (DMA) applied small‐strain cyclic deformations to simulate physiological loading. effect two fillers on...