A5017115792- Carcinogens and Genotoxicity Assessment
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical studies and practices
- Dye analysis and toxicity
- Phytochemistry Medicinal Plant Applications
- Garlic and Onion Studies
- Phytochemistry and biological activity of medicinal plants
- Respiratory and Cough-Related Research
- Plant tissue culture and regeneration
- Phytochemical and Pharmacological Studies
- Genetically Modified Organisms Research
- Radiation Therapy and Dosimetry
- Curcumin's Biomedical Applications
- Pesticide Exposure and Toxicity
- Chemical Safety and Risk Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Biological Research and Disease Studies
- Enzyme Production and Characterization
- Environmental Sustainability and Education
- Geography and Environmental Studies
- Hibiscus Plant Research Studies
- Food Quality and Safety Studies
- Antibiotic Use and Resistance
Universidade Estadual de Mato Grosso do Sul
2015-2024
European Union of Medical Specialists
2009-2023
Universidade Federal da Grande Dourados
2021
Universidade Estadual de Maringá
2009-2014
Capsaicin (CAP) is the main compound responsible for spicy flavor of Capsicum plants. However, its application can be inhibited due to pungency and toxicity. This study aimed evaluate compare cytotoxic effect CAP analogs N-benzylbutanamide (AN1), N-(3-methoxybenzyl) butanamide (AN2), N-(4-hydroxy-3-methoxybenzyl) (AN3), hexanamide (AN4) tetradecanamide (AN5) on hepatoma cells Rattus norvegicus using MTT test. The results showed cytotoxicity at concentrations 100, 150, 175, 200 μM (24 hours),...
The increasing consumption of fruits and vegetables has contributed to the improvement populational health, due in part, abundance antioxidants these foods. Antioxidants reduce level oxidative damage DNA caused by free radicals ionizing radiation, including radioisotope iodine-131 (131I). This isotope is used for diagnosis treatment thyroid injuries, such as hyperthyroidism cancer.This study aimed evaluate radioprotective cytotoxic activity acute subchronic treatments with Barbados Cherry...
Radioactive iodine-131 (131I) is used in the treatment and diagnosis of thyroid gland injuries.However, because it emits ionizing radiation, causes harmful effects to cells.Given that betacarotene (BC) has antioxidant antigenotoxic properties, this study aimed investigate its radioprotective antimutagenic activity relation 131I at dose treat hyperthyroidism using a test system bone marrow cells from Wistar rats (Rattus norvegicus).The doses were 0.2 mL 8 mg BC/mL corn oil 25 μCi per 100 g...
Due to the large consumption of soft drinks in Brazil and worldwide recent years considering that some components present their composition pose potential risks human health, aim this study was evaluate cytotoxic mutagenic specific cola grape-flavored drink brands. Bone marrow cells Wistar rats were initially treated by gavage with one single dose Cola or Grape drink, which next offered ad libitum (instead water) for 24 hours. A negative control treatment performed administering water a...
Fruits are important sources of nutrients in human diet, and Barbados Cherry (Malpighia glabra L.) is particular interest due to its high content antioxidants. Diets rich fruits vegetables protect individuals against diseases cancer, but excessive intake vitamins may act as pro-oxidant generate changes DNA. To evaluate the effect different natura (BAN) frozen (BAF) pulp concentrations synthetic vitamin C liquid form (VC) on chromosome level cell cycle division, root meristeme cells Allium...
The Ivinhema River Basin is affected by the expansion of sugarcane cultivation areas, which impacts water quality ofits streams. aim this study was to evaluate cytotoxic, genotoxic, and mutagenic potential samples fromthree streams using Allium cepa test. Sampling conducted in March 2017. Surfacewater collected from Piravevê, Vitória, Rosário induced cytotoxic genotoxic effects A. cepa.Reductions both germination cell division were observed, may have been related flow toxic residuesfrom...
Medicinal plants such as Aloe arborescens Miller and barbadensis are used by the general population to treat various diseases. Therefore, aim of this study was evaluate antimutagenicity these two species using a methG1 system in Aspergillus nidulans comet assay rats. The animals were treated with at concentrations 360 720 mg/kg body weight (1 2, respectively) gavage for 14 days, followed administration etoposide on treatment day 8. Blood samples prepared analysis DNA damage. For test A....
The Ivinhema River basin has experienced the greatest expansion of sugarcane cultivation in state Mato Grosso do Sul, Brazil. Theassessment water quality through physical and chemical parameters ecotoxicological studies, employing both bioindicators collected situ laboratory tests, provides more robust results for this region. In context, objective study was to analyze composition structure landscape around sampling sites located three streams (Vitória, Rosário, Piravevê) belonging evaluate...
Abstract Studies show that propolis has antimicrobial, antifungal, antiviral, anti-inflammatory, antioxidant, antitumor, and immunomodulatory properties, may protect against diseases such as diabetes, cardiovascular disease, cancer. We aimed to extract compounds of brown with hydroalcoholic solvents evaluate their cytotoxic activity on tumor non-tumor cells by MTT test. tested the solute:solvent ratio (ethanol:water) extraction time in a Shaker incubator (710 rpm) before conducting central...
RESUMOA pesquisa de produtos naturais benéficos à saúde humana vem crescendo nos últimos 20 anos. Considerando que as plantas Aloe são amplamente utilizadas pela população humana, em geral maneira terapêutica, o objetivo deste estudo foi avaliar os efeitos Aloearborescens Miller e barbadensis Miller, sobre desenvolvimento vegetativo linhagens normais mutantes Aspergillus nidulans. Conídios da linhagem biA1methG1, MSE CLB3 A. nidulans, foram inoculados meio completo sem (Controle) com...
Currently, a large part of the female population uses contraceptive methods due to benefits provided by this medication. These drugs can be found in oral or injectable form and are basic compounds for progestogen estrogen. However, despite benefits, these contraceptives cause number harmful effects as women, continuous prolonged use, addition problem being excreted sewers, daily, causing problems animals exposed. In context, present study aimed evaluate cytotoxic mutagenic potential...
Abstract The study aim was to evaluate the cytotoxic activity, using MTT test [3-(4,5-Dimethilthiazol-2-yl)-2,5-diphenil tetrazolium bromide], from crude extract of Picrasma crenata (Pau Tenente) and its isolated compounds, quassin parain, in culture rat liver tumor cells (HTC). carried out exposing for 24, 48 72 hours concentrations 5, 10, 50, 100, 200, 300, 400, 500 1000 μg Pau Tenente/mL medium 1, 15, 20, 40, 60, 80 100 or parain compounds/mL medium. absorbances averages results obtained...
Apesar da questão frugalidade estar presente no discurso acadêmico por mais tempo, o termo “inovação frugal” tem sido utilizado com maior frequência na última década. Conhecer as iniciativas é fundamental para amadurecer a visão de oportunidades, processos indutores e preparar ecossistema inovação reconhecer particularidades desenvolver inovações frugais Brasil. que desenvolvido pelas universidades torna-se preponderante nesse processo, nessa perspectiva, este artigo como objetivo analisar...
Abstract Averrhoa carambola L. presents in its composition diversity of nutrients and vitamins. The present study aimed to extract water fat-soluble compounds from this fruit at different stages maturation (green mature), perform the physical-chemical characterization as well evaluate cytotoxicity against hepatoma cells Rattus norvegicus (HTC). physicochemical results showed that pH molar acidity is influenced by state. presented high percentage moisture, while total minerals (ash) increased...