A5073629767- Inflammatory Bowel Disease
- Human Health and Disease
- Microscopic Colitis
- Liver Diseases and Immunity
- Peroxisome Proliferator-Activated Receptors
- Biomarkers in Disease Mechanisms
- Immune Response and Inflammation
- Diet and metabolism studies
- Inflammation biomarkers and pathways
- Inflammatory Biomarkers in Disease Prognosis
- Autoimmune and Inflammatory Disorders Research
- Liver Disease Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Vitamin D Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Immune cells in cancer
- Digestive system and related health
- Pharmacological Effects of Natural Compounds
- Adolescent and Pediatric Healthcare
Center for Children
2020-2023
Scientific Center of Children's Health
2020
Ministry of Health of the Russian Federation
2020
A long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency is a hereditary disease referred to the group of disorders mitochondrial β-oxidation fatty acids. The inheritance mechanism autosomal recessive. several main symptoms include hypoglycemia, liver steatosis, cardiomyopathy, cardiac arrhythmias, progressive muscle hypotension. Laboratory signs relative increase in concentration acids, as determined by tandem mass spectrometry. Also, characteristic feature low rate free carnitine (C0),...
Myeloid-derived suppressor cells (MDSCs) play an important role in regulation of immune response. An increase their number adult patients with autoimmune diseases has been reported. G-MDSCs, M-MDSCs, and MDSCs(M-G-) at different stages disease may both activate T cell proliferation, leading to progression, or inhibit it, thus promoting Treg differentiation. Arginase-1 (Arg- 1) is enzyme MDSCs that reduces the concentration arginine required for lymphocyte proliferation. Our aim was evaluate...
Objective. To evaluate the efficacy and safety of vedolizumab in children with inflammatory bowel disease (IBD) to supplement existing data on experience its use pediatric patients. Patients methods. The therapy IBD was assessed by analyzing observational 37 patients aged 6 17 years (29 ulcerative colitis (UC), 8 Crohn’s (CD)) for period 2019–2023. mean age at initiation 13 years. Prior treatment all included anti-TNF (tumor necrosis factor) agents. Clinical endoscopic indices activity,...
BACKGROUND: Inflammatory bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) affect more than 6.8 million people. The key factor in the immunopathogenesis of these is intestinal wall infiltration by various immunocompetent cells their proinflammatory cytokine production. AIM: To compare levels 14 cytokines coproextracts patients with IBD activities. MATERIALS AND METHODS: examined cohort comprised 30 children CD, 33 UC, 20 healthy (control group). UC CD were...
Abstract Background Anaemia is a frequent extraintestinal manifestation of inflammatory bowel diseases (IBD) and its severity leads to deterioration in patient’s condition. Timely diagnosis pathogenetic therapy are important for the effective treatment. The aim this study was evaluate current cell indexes obtained from automatic blood analyser identify features anaemia children with IBD. Methods A total 1400 samples were analysed 420 IBD (177—Crohn’s disease (CD) 243—ulcerative colitis (UC))...
Objective. To evaluate the accuracy and informativeness of two endoscopic indices for ulcerative colitis (UC) activity recommended pediatric practice (Ulcerative Colitis Endoscopic Index Severity (UCEIS) Mayo ES) analyze their correlation with clinical laboratory indicators disease activity. Patients methods. This study included 80 patients (42 boys, 38 girls) aged 5 to 18 years diagnosed UC. The UC was evaluated using Pediatric Ulcerative Activity (PUCAI). Laboratory examination measurement...
Timely diagnosis and monitoring of ulcerative colitis (UC) in children is extremely relevant. In recent years, much attention has been paid to improving noninvasive UC methods, which are available convenient the practice a doctor. this regard, we analyzed significance changes laboratory parameters sick with different clinical endoscopic activity. Materials methods. A prospective analysis data 80 patients diagnosed at age 1 18 years varying degrees activity disease was performed. Results....
Objective. To study vitamin D status in children with inflammatory bowel diseases (IBD) depending on the diagnosis, gender, age and a season of examination. Patients methods. The included 244 (130 boys 114 girls) aged 3 to 18 years. patients were divided into 2 groups nosological form disease: Crohn’s disease (CD) – 130 children, ulcerative colitis (UC) children. Blood levels determined by method competitive electrochemiluminescence. Results. Normal (>30 ng/ml) found only 11.1% IBD (in...
Aim: to establish the patterns of changes in leukocyte blood parameters determine their diagnostic significance different activity Crohn’s disease (CD) and ulcerative colitis (UC) children. Materials methods. 370 5-18-year children (198 boys, 172 girls) with inflammatory bowel (IBD) were examined. Leukocytic parameters, concentrations C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), faecal calprotectin (FC) levels determined. Changes clinical cases determined using pediatric...
Objective. To analyze the connection between complex of platelet indices in complete blood count test with clinical and endoscopic activity scores for Crohn's disease (CD) ulcerative colitis (UC) pediatric patients to determine their most informative threshold values. Patients methods. In this study, 370 children aged 5 18 years diagnosed CD (n = 150) UC 220) were examined. The was assessed according PUCAI, – PCDAI; assessment carried out UCEIS SES-CD. study included 630 tests (270 360 UC):...