A5075387650- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Medical Imaging Techniques and Applications
- HIV Research and Treatment
- Malaria Research and Control
- Virology and Viral Diseases
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Radiomics and Machine Learning in Medical Imaging
- Vibrio bacteria research studies
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- COVID-19 diagnosis using AI
- Viral gastroenteritis research and epidemiology
- Insect symbiosis and bacterial influences
- Enzyme Structure and Function
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Influenza Virus Research Studies
- COVID-19 and Mental Health
- Animal Virus Infections Studies
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
Chandigarh University
2025
All India Institute of Medical Sciences Raipur
2024
Washington University in St. Louis
2021-2023
Indo Soviet Friendship College of Pharmacy
2023
National Institute of Technology Karnataka
2021-2022
Sardar Vallabhbhai National Institute of Technology Surat
2022
Indian Institute of Technology Mandi
2016-2022
Sardar Patel Medical College
2022
Govind Ballabh Pant University of Agriculture and Technology
2019
Cadila Healthcare (India)
2019
Over the last few decades, concepts of protein intrinsic disorder have been implicated in different biological processes. Recent studies suggested that intrinsically disordered proteins (IDPs) provide structural plasticity and functional diversity to viral are involved rapid replication immune evasion host cells. In case Zika virus, roles mechanisms pathogenesis not completely understood. this study, we analyzed prevalence virus proteome (strain MR 766). Our analyses revealed polyprotein is...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses—including SARS-CoV, MERS-CoV, SARS-CoV-2—is the papain-like protease (PLpro). PLpro cleaves part viral replicase polyproteins into non-structural protein subunits, which are essential replication cycle. Additionally, can cleave both ubiquitin ubiquitin-like ISG15 host...
Since 2007, repeated outbreaks of Zika virus (ZIKV) have affected millions people worldwide and created a global health concern with major complications like microcephaly Guillain Barre's syndrome. To date, there is not single Zika-specific licensed drug present in the market. However, recent months, several antiviral molecules been screened against ZIKV. Among those, (-)-epigallocatechin-3-gallate (EGCG), green tea polyphenol, has shown great virucidal potential flaviviruses including The...
Zika virus (ZIKV) spread led to the recent medical health emergency of international concern. Understanding variations in system is utmost need. Using available complete sequences ZIKV we estimated directions mutational pressure along length consensus three lineages virus. Results showed that guanine usage growing RNA plus strand due adenine transitions, while cytosine transversions. Especially high levels have been found twofold degenerated sites certain areas with amount secondary...
Japanese encephalitis virus (JEV) is one of the major causes viral all around globe. Approximately 3 billion people in endemic areas are at risk encephalitis. To develop a wholistic understanding proteome, it important to investigate both its ordered and disordered proteins. However, functional structural significance regions JEV proteome has not been systematically investigated as yet. fill this gap, we used here set bioinformatics tools analyze for predisposition proteins intrinsic...
The spread of COVID-19 has been exacerbated by the emergence variants concern (VoC). Many VoC contain mutations in spike protein (S-protein) and are implicated infection response to therapeutics. Bivalent neutralizing antibodies (nAbs) targeting S-protein receptor-binding domain (RBD) promising therapeutics for COVID-19, but they limited low potency vulnerability RBD VoC. To address these issues, we used naïve phage-displayed peptide libraries isolate optimize 16-residue peptides that bind...
Immune hemolytic anemia is a rare adverse effect of ceftriaxone, third-generation cephalosporin, which commonly used antibiotic. We describe 60-years-old lady, case community-acquired pneumonia, who developed severe hemolysis after the first dose ceftriaxone. Her hemoglobin dropped from 9.6 g /dl to 5.5 /dl. However, she improved discontinuation drug and blood transfusion. This report serves as reminder medical fraternity that life-threatening can rarely follow administration
To determine the diagnostic reliability of 18F-FDOPA, 13N-Ammonia and 18F-FDG PET/CT in primary brain tumors comparison with magnetic resonance imaging (MRI).A total 23 patients, 8 preoperative 15 postoperative, undergoing evaluation for were included this study. Of them, 9/15 operated high grade gliomas (7/9 astrocytomas 2/9 oligodendrogliomas) 6/15 low (5/6 1/6 oligodendroglioma). After PET study, 2 cases histopathologically proven to be benign etiology. 3 postoperative disease free on 6...
Neutralizing antibodies (nAbs) that target the SARS-CoV-2 spike protein have received emergency use approval for treatment of COVID-19. However, with emergence variants concern, there is a need new options. We report format enables modular assembly bi-paratopic tetravalent nAbs antigen-binding sites from two distinct nAbs. The nAb purifies in high yield and exhibits biophysical characteristics are comparable to those clinically used therapeutic antibodies. binds trimer at least 100-fold more...
ZIKV belongs to a flavivirus family in which class II fusion proteins involve low pH-dependent membrane leading infection of host cells. Envelope (E) protein is primarily responsible for the viral and major target inhibiting entry. Our findings reveal that compounds like PGG, Parishin A, Stevioside have shown high affinity E found be active against various other infections. The binding these molecules was decrease RMSD RMSF values ligand complex restricted Radius Gyration molecular dynamics...
Stock market investment, due to its volatile nature and dependence on many factors like own company policies, other companies' stock value, people's outlook the company, etc., is a big gamble. However, if understood, it can heap in rewards investors. This one of reasons why analysis has been such hot topic highly researched field. Fundamental Technical are two ways study predict future stocks. A lot work done previously prices using either sentiment or historical data, but very little...
Viral inclusion bodies (IBs) are potential sites of viral replication and assembly.How IBs form remains poorly defined.Here we describe a combined biophysical cellular approach to identify the components necessary for IB formation during Ebola virus (EBOV) infection.We find that eNP 0 VP35 complex containing nucleoprotein (eNP) protein 35 (eVP35), functional equivalents (N) phosphoprotein (P) in non-segmented negative strand viruses (NNSVs), phase separates bodies.Phase separation is...
ABSTRACT Since 2007, repeated outbreaks of Zika virus (ZIKV) has affected millions people worldwide and created global health concern with major complications like microcephaly Guillain Barre’s syndrome. Generally, ZIKV transmits through mosquitoes (Aedes aegypti) other flaviviruses, but reports show blood transfusion sexual mode transmission which further makes the situation alarming. Till date, there is not a single specific licensed drug or vaccine present in market. However, recent...
Background: Rabies is a zoonotic disease caused by RNA (ribonucleic acid) viruses of the genus, Lyssavirus family, Rhabdoviridae. Limited supply, cost and potential for severe adverse effects observed with blood derived rabies immunoglobulin products has led to search alternative therapies. To address this issue, Cadila Healthcare Ltd. in collaboration World Health Organization (WHO) developed an anti-rabies monoclonal antibody cocktail based product.Methods: This was phase 3, randomized,...
Transactivation domain of Adenovirus Early region 1A (E1A) oncoprotein is an intrinsically disordered molecular hub protein. It involved in binding to different domains human cell transcriptional co-activators such as retinoblastoma (pRb), CREB-binding protein (CBP), and its paralogue p300. The conserved 1 (TAD) E1A known undergo structural transitions folds upon interaction with adaptor zinc finger 2 (TAZ2). Previous reports on Taz2-E1A studies have suggested the formation helical...