A5074716256- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Diversity and Career in Medicine
- EEG and Brain-Computer Interfaces
- Glycogen Storage Diseases and Myoclonus
- Healthcare professionals’ stress and burnout
- Medical Education and Admissions
- Metabolism and Genetic Disorders
- Child and Adolescent Health
- RNA Research and Splicing
- Neurology and Historical Studies
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Diet and metabolism studies
- RNA modifications and cancer
- Maternal Mental Health During Pregnancy and Postpartum
- Neurological and metabolic disorders
- Neuroscience and Neuropharmacology Research
- RNA and protein synthesis mechanisms
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Autoimmune Neurological Disorders and Treatments
- Parasitic Diseases Research and Treatment
- Homicide, Infanticide, and Child Abuse
Presidency University
2024
Riyadh Armed Forces Hospital
2001-2024
Ziauddin University
2024
Himachal Pradesh University
2024
Fundação para a Ciência e Tecnologia
2024
Icahn School of Medicine at Mount Sinai
2017-2022
Harvard University
2022
Boston University
2022
Hartford Hospital
2022
Elmhurst Hospital Center
2022
The error-related negativity (ERN) and feedback-related (FRN) have been used as electrophysiological indices of performance monitoring produced in response to internally generated (errors) externally (feedback) activations the anterior cingulate cortex (ACC). No studies date systematically examined measurement reliability these components. In this article, we present retest ERN FRN during tasks designed elicit errors or feedback responses on two occasions. Data from four experiments are...
To investigate the clinical, genetic, and neuroradiologic data of biotin-responsive basal ganglia disease (BBGD) clarify spectrum.We first investigated all patients attending our Division Pediatric Neurology with a genetically proven diagnosis BBGD between 2009 2011. All underwent detailed medical history clinical examination, extensive laboratory investigations including genetic tests, brain MRI. Finally, we conducted systematic review literature.We enrolled 10 meeting diagnostic criteria...
Epileptic encephalopathies are an epileptic condition characterized by epileptiform abnormalities associated with progressive cerebral dysfunction. In the classification of International League Against Epilepsy eight age-related encephalopathy syndromes recognized. These include early myoclonic and Ohtahara syndrome in neonatal period, West Dravet infancy, status nonprogressive encephalopathies, Lennox-Gastaut syndrome, Landau-Kleffner epilepsy continuous spike waves during slow wave sleep...
Oligodendrocyte (OLG)-related abnormalities have been broadly observed in schizophrenia (SZ); however, the etiology of these remains unknown. As SZ is believed to be a developmental disorder, myelin may related OLG fate specification during development. Noncoding RNAs (ncRNAs) are an important part multifaceted transcriptional complexes participating neurogenic commitment and regulation postmitotic cell function. The long ncRNA, NEAT1, structural component paraspeckles (subnuclear bodies...
Objective: To compare standard analgesia alone versus addition of intra-operative local anesthesia in postoperative pain management among patients undergoing laparoscopic cholecystectomy. Study Design: Quasi experimental study. Place and Duration Study: Combined Military Hospital, Multan Pakistan, from Jul 2022 to Apr 2023. Methodology: Eighty (n=80) were divided two equal groups by draws method (Group A B). Group was managed plus intra–operative while group B only analgesia. Post-operative...
There is a scarcity of specialist trainers and supervisors for psychosocial interventions in low- middle-income countries. A cascaded model training supervision was developed to sustain delivery an evidence-based peer-delivered intervention perinatal depression (the Thinking Healthy Programme) rural Pakistan. The study aimed evaluate the model.Mixed methods were employed as part randomised controlled trial intervention. Quantitative data consisted peers' competencies assessed during field...
Two cases of alternating hemiparesis are reported, one in a black Sudanese woman, the other Saudi man, who had two episodes separated time by six and three years respectively. Based on typical appearance MRI results brain biopsy, diagnosis multiphasic disseminated encephalomyelitis was made rather than that multiple sclerosis. This entity is also differentiated from recurrent encephalomyelitis, where relapses symptomatically stereotyped although similar which new lesions do not occur....
A large body of literature links risk cognitive decline, mild impairment (MCI) and dementia with Type 2 Diabetes (T2D) or pre-diabetes. Accumulating evidence implicates a close relationship between the brain insulin receptor signaling pathway (IRSP) accumulation amyloid beta hyperphosphorylated conformationally abnormal tau. We showed previously that neuropathological features Alzheimer’s disease (AD were reduced in patients diabetes who treated oral antidiabetic medications. To understand...
Introduction The gender and racial profile of the pediatric population in United States (US) is more diverse than that pediatricians cater to their healthcare needs. Gender diversity remains limited among residents fellows, faculty, leadership. Our study objectives were explore disparity US. Methods This was a retrospective analysis Accreditation Council for Graduate Medical Education (ACGME) database. database encompassed all US pediatrics residency programs from 2007 2021, categorizing...
Abstract Introduction Molecular responses in the brains of persons with mild cognitive impairment (MCI), earliest transitional state between normal aging and early Alzheimer's disease (AD), are poorly understood. Methods We examined AD‐related neuropathology transcriptome changes neocortex individuals MCI relative to controls temporal hypoxia mouse brains. Results Subsets vascular response genes were upregulated prior buildup AD neuropathology. Early activation pro‐angiogenic...
Autoimmune encephalitis is rare. Several auto- antibodies are described in autoimmune encephalitis. We describe a case of limbic associated with positive voltage gated potassium channel (VGKC) and leucine-rich glioma inactivated protein 1 (LGI1). A 33-year-old Saudi housewife, she presented 2 months history cognitive deterioration recurrent left facio-brachial dystonic seizures followed by generalized tonic clonic seizures. At times the preceded rising epigastric aura shortness breath. The...
Abstract Background Exposure to violence is associated with psychological distress, mental disorders such as depression, and suicidal behaviour. Most of the studies are conducted in West, limited publications from Asia. Thus, we a scoping review investigating association between experiences later ideation/attempts Asia twenty-first century. Results Many focused on domestic toward women Southeast Asian region. Sociocultural factors family disputes, public shaming, dowry, lack education...
Genetic, neuroimaging, and gene expression studies suggest a role for oligodendrocyte (OLG) dysfunction in schizophrenia (SZ). Disrupted-in-schizophrenia 1 (DISC1) is risk major psychiatric disorders, including SZ. Overexpression of mutant truncated (hDISC1), but not full-length sequence human DISC1 forebrain influenced OLG differentiation proliferation glial progenitors the developing cerebral cortex concurrently with reduction progenitor markers hindbrain. We examined protein molecular...
The world is increasingly changing, with climate change, pandemics, and wars becoming key factors. recent pandemic devastated the tourism industry, leading to a sudden collapse of global economy. Historically disastrous situations are well known for their impact on innovations technological advances. Therefore, in light idea that disasters can act as catalyst innovation transformation, researchers attempted conceptualise new strategies destination development management from perspective...
Super-refractory status epilepticus is defined as that continues or recurs 24 h more after the initiation of anesthetic therapy(continuum), a serious medical emergency with potential for significant morbidity and mortality. Cortisectomy invasive EEG recording electrocorticography (ECoG) can be successful treatment option super-refractory in selected cases management has failed.