A5091614226- Genomics, phytochemicals, and oxidative stress
- Nutritional Studies and Diet
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Biochemical Acid Research Studies
- Liver Disease Diagnosis and Treatment
- Circadian rhythm and melatonin
- Metabolism, Diabetes, and Cancer
- PI3K/AKT/mTOR signaling in cancer
- Glutathione Transferases and Polymorphisms
- Diet, Metabolism, and Disease
- Renal Diseases and Glomerulopathies
- Urticaria and Related Conditions
- Gut microbiota and health
- Tryptophan and brain disorders
- Vitamin C and Antioxidants Research
- Sports injuries and prevention
- Mast cells and histamine
- Electrolyte and hormonal disorders
- Olfactory and Sensory Function Studies
- Pancreatic function and diabetes
- Asthma and respiratory diseases
- Phytoestrogen effects and research
- Dermatology and Skin Diseases
- Biochemical effects in animals
Hirosaki University
2020-2023
Tokyo University of Agriculture and Technology
2016
To confirm the usefulness of noninvasive measurements skin carotenoids to indicate vegetable intake and elucidate relationships between carotenoid levels biomarkers circulatory diseases metabolic syndrome, we conducted a cross-sectional study on resident-based health checkup (
Sulforaphane (SFN) is a potent activator of the transcriptional factor, Nuclear Factor Erythroid 2 (NF-E2)-Related factor (NRF2). SFN and its precursor, glucoraphanin (sulforaphane glucosinolate, SGS), have been shown to ameliorate cognitive function in clinical trials vivo studies. However, effects SGS on age-related decline Senescence-Accelerated Mouse Prone 8 (SAMP8) unknown. In this study, we determined preventive potential decline. One-month old SAMP8 mice or control SAM resistance 1...
The influx of intestinal bacteria-derived lipopolysaccharide (LPS) into the blood has attracted attention as a cause diseases. aim this study is investigating associations between LPS, dietary factors, gut microbiota, and health status in general adult population. Food/nutrient intake, plasma LPS-binding protein (LBP; LPS exposure indicator) were measured 896 residents (58.1% female, mean age 54.7 years) rural Iwaki district Japan, each correlation was analyzed. As results, LBP concentration...
Purpose Pulse wave velocity (PWV), an indicator of vascular stiffness, increases with age and is increasingly recognized as independent risk factor for cardiovascular disease (CVD). Although many mechanical chemical factors underlie the stiffness elastic artery, genetic related to age-dependent in PWV apparently healthy people are largely unknown. The transcription nuclear E2 (NF-E2)-related 2 (Nrf2), which activated by unidirectional pulsatile shear stress or oxidative stress, regulates...
Consumption of fruits and vegetables rich in carotenoids has been widely reported to prevent cardiovascular diseases. However, the relationship between serum carotenoid concentrations visceral fat area (VFA), which is considered a better predictor diseases than body-mass index (BMI) waist circumference, remains unclear. Therefore, we examined healthy individuals their 20s or older, stratified by sex age, compare VFA BMI. The study was conducted on 805 people, residents Hirosaki city, Aomori...
Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin, has antioxidant, and anti-inflammatory effects that may be beneficial for improving liver function. However, few studies regarding the of glucoraphanin on biological markers related to function, such as alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyltransferase (γ-GTP) in healthy individuals have been reported. This randomized, double-blind, placebo-controlled parallel- group trial was conducted April 22...
OBJECTIVE To characterize platelet-activating factor (PAF)-induced edema and erythema in the skin of dogs compare those reactions with histamine-induced cutaneous reactions. ANIMALS 6 healthy Beagles. PROCEDURES Experiments were performed at ≥ 2-week intervals. Each dog received ID injections (5 μg/site) PAF C16, C18, lyso-PAF, histamine. Edema (mean diameter) scores (none, mild, moderate, or severe) assessed 30 minutes after injections. Dogs histamine each various concentrations WEB 2086...
小児特発性ネフローゼ症候群 (NS) では大部分の症例がグルココルチコイド療法により寛解するが，NSの発症病理に関するグルココルチコイドの役割は十分に解明されておらず，また治療抵抗性を認める症例の原因も明らかではない。我々はNS患者を中心にステロイド感受性に関するグルココルチコイドの分子作用機序についてその遺伝子転写調節の細胞内メッセンジャーであるグルココルチコイドレセプター (GR) とその発現制御因子についての解析を行った。その結果，頻回再発型ならびにステロイド抵抗性ネフローゼ症候群にGR発現量の低下を高頻度に認め，これらの症例ではGR Down regulationによるステロイド依存性転写調節障害が示唆された。またレセプタ一結合蛋白である熱ショック蛋白はGR発現量と相関することよりグルココルチコイドーGR系の情報伝達が阻害されステロイド抵抗性の原因となることが示唆された。