A5055728915- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sinusitis and nasal conditions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune responses and vaccinations
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Myeloid Leukemia Treatments
- Ion Channels and Receptors
- Inflammation biomarkers and pathways
- Mitochondrial Function and Pathology
- Biochemical Analysis and Sensing Techniques
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- Epilepsy research and treatment
- Lung Cancer Research Studies
- Gut microbiota and health
- Nasal Surgery and Airway Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroscience of respiration and sleep
Amsterdam University Medical Centers
2022-2025
Public Health Service of Amsterdam
2023-2025
University of Amsterdam
2023-2025
Harvard University
2024
Abstract Background In the Netherlands, prevalence of post COVID-19 condition is estimated at 12.7% 90–150 days after SARS-CoV-2 infection. This study aimed to determine occurrence fatigue and other symptoms, assess how many patients meet Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) criteria, identify symptom-based clusters within P4O2 cohort compare these with in a ME/CFS cohort. Methods this multicentre, prospective, observational 95 aged 40–65 years were included. Data...
An estimated 10% of COVID-19 survivors have been reported to suffer from complaints after at least three months. The intestinal microbiome has shown impact long COVID through the gut-lung axis and severity. We aimed investigate relationship between gut clinical characteristics, exploring heterogeneity clustering. Seventy-nine patients with evaluated 3 6 months infection were sampled for fecal metagenome analysis. Patients divided into two distinct hierarchical clusters, based solely on...
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has led to the death of almost 7 million people, however, with a cumulative incidence 0.76 billion, most people survive COVID-19. Several studies indicate that acute phase COVID-19 may be followed by persistent symptoms including fatigue, dyspnea, headache, musculoskeletal symptoms, and pulmonary functional-and radiological abnormalities. However, impact on long-term health outcomes remains elucidated. Aims: Precision Medicine...
Background Four months after SARS-CoV-2 infection, 22%–50% of COVID-19 patients still experience complaints. Long COVID is a heterogeneous disease and finding subtypes could aid in optimising developing treatment for the individual patient. Methods Data were collected from 95 P4O2 cohort at 3–6 infection. Unsupervised hierarchical clustering was performed on patient characteristics, characteristics acute long symptom data, lung function questionnaires describing impact severity COVID. To...
Background: While some long-term effects of COVID-19 are respiratory in nature, a non-respiratory effect gaining attention has been decline hemoglobin, potentially mediated by inflammatory processes. In this study, we examined the correlations between hemoglobin levels and biomarkers evaluated association fatigue cohort Long-COVID patients. Methods: This prospective study Netherlands 95 (mostly hospitalized) patients, aged 40–65 years, 3–6 months post SARS-CoV-2 infection, examining their...
In the randomized double-blind placebo-controlled CounterCOVID study, oral imatinib treatment conferred a positive clinical outcome and signal for reduced mortality in COVID-19 patients. High concentrations of alpha-1 acid glycoprotein (AAG) were observed these patients associated with increased total concentrations.This post-hoc study aimed to compare difference exposure following administration cancer assess assocations between pharmacokinetic (PK) parameters pharmacodynamic (PD) outcomes...
Background Months after infection with SARS-CoV-2, at least 10% of patients still experience complaints. Long-COVID is a heterogeneous disease and clustering efforts revealed multiple phenotypes on clinical level. However, the molecular pathways underlying long-COVID are poorly understood. Objectives This study aims to cluster according their blood transcriptomes uncover disease. Methods Blood was collected from 77 P4O2 COVID-19 study. Unsupervised hierarchical performed whole transcriptome....
Influenza viruses are a major global cause of morbidity and mortality. Vagal TRPV1
Although the coronavirus disease 2019 (COVID-19) pandemic is no longer a public health emergency of international concern, 30% COVID-19 patients still have long-term complaints. A better understanding progression symptoms after needed to reduce burden post condition.
Background/objectives: A significant number of COVID-19 cases experience persistent symptoms after the acute infection phase, a condition known as long COVID or post-acute sequelae COVID-19. Approved prevention and treatment options for are currently lacking. Given heterogeneous nature COVID, personalized medicine approach is essential effective disease management. This study aimed to describe trends in pharmacotherapy from pre-COVID post-COVID phases gain insights into strategies assess...
<b>Introduction:</b> Several studies indicate that the acute phase of COVID-19 may be followed by persistent symptoms. However, impact on long-term health outcomes remains to elucidated. <b>Aims:</b> The Precision Medicine for more Oxygen (P4O2) study aims identify long COVID patients are at risk developing chronic lung disease and treatable traits innovative personalized therapeutic strategies prevention treatment. This describes baseline characteristics P4O2 cohort. <b>Methods:</b> Long...
<b>Background:</b> Six months after SARS-CoV-2 infection, 31-69% of COVID-19 patients still experience complaints. Long COVID is a heterogeneous disease and finding subtypes could aid in patient recovery. <b>Methods:</b> Data was collected from the 95 P4O2 cohort at 3 to 6 infection. Patients were clustered using data obtained characteristics, characteristics acute SARS-CoV-2 long symptom data, lung function questionnaires describing impact severity COVID. then hierarchal clustering....
<b>Introduction:</b> Long COVID is described as the persistence of symptoms following acute COVID-19 for >12 weeks and occurs in about 30% all cases. Nasal epithelium a primary target SARS-CoV-2 involved early phase immune response. <b>Aims:</b> To assess role nasal local tissue micro-environment long COVID. <b>Methods:</b> Phenotype function innate lymphoid cells(ILC) were analyzed from patients healthy controls(HC) using quantitative polymerase chain reaction, transepithelial...
<b>Background:</b> Some patients do not fully recover after COVID-19 and have symptoms occurring 3 months acute illness, lasting for >2 months, defined as post COVID-19. Fatigue seems most present in part of the might develop similar to chronic fatigue syndrome. <b>Aim:</b> To determine occurrence other patients. <b>Methods:</b> In prospective P4O2 cohort, aged 40-65 years were recruited from outpatient post-COVID clinics 5 Dutch hospitals between May 2021-September 2022. At 3-6...
<b>Background:</b> It is unclear whether patient characteristics or features of acute COVID-19 are associated with decreased pulmonary function following a SARS-CoV-2 infection. <b>Aims:</b> To describe 3-6 months and to evaluate potential predictors function. <b>Methods:</b> In this prospective cohort study, 95 patients aged 40-65 years were recruited from outpatient post-COVID clinics in 5 Dutch hospitals between May 2021 September 2022. At post-COVID, medical records data biological...
<b>Introduction:</b> Long COVID is described as the persistence of symptoms following acute COVID-19 for &gt;12 weeks and occurs in about 30% all cases. Nasal epithelium a primary target SARS-CoV-2 involved early phase immune response. <b>Aims:</b> To assess role nasal local tissue micro-environment long COVID. <b>Methods:</b> Phenotype function innate lymphoid cells(ILC) were analyzed from patients healthy controls(HC) using quantitative polymerase chain reaction, transepithelial...