A5021528391- Cardiac Fibrosis and Remodeling
- Viral Infections and Immunology Research
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- CAR-T cell therapy research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- T-cell and B-cell Immunology
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- interferon and immune responses
- Social Sciences and Governance
- Cybersecurity and Cyber Warfare Studies
- Energy and Environment Impacts
- Private Equity and Venture Capital
- Cardiac tumors and thrombi
- Cancer Immunotherapy and Biomarkers
- Privacy, Security, and Data Protection
- Online Learning and Analytics
- Firm Innovation and Growth
- Digitalization, Law, and Regulation
- Peptidase Inhibition and Analysis
- Resilience and Mental Health
- Diabetes and associated disorders
- Entrepreneurship Studies and Influences
Johns Hopkins Medicine
2022-2024
Johns Hopkins University
2022-2024
University of Baltimore
2023
Introduction Growing evidence from animal models indicates that the myocardium hosts a population of B cells play role in development cardiomyopathy. However, there is minimal data on human myocardial context Methods We integrated single-cell and single-nuclei datasets 45 healthy hearts, 70 hearts with dilated cardiomyopathy (DCM), 8 arrhythmogenic right ventricular (ARVC). Interactions between other cell types were investigated using CellChat Package. Differential gene expression analysis...
Cardiac immunology studies in murine models have identified a sizeable population of myocardial B-cells and shown that its modulation represents promising strategy to develop novel therapies for heart failure. However, scarce data on the human leaves unclear whether findings rodents are relevant biology. We performed immunohistochemical stains characterize amount distribution hearts, analyzing both fresh post-mortem tissue. To gain insight into biology we analyzed publicly-available spatial...
<title>Abstract</title> Cardiovascular disease remains the leading cause of death worldwide. A primary driver cardiovascular mortality is ischemic heart failure, a form cardiac dysfunction that can develop in patients who survive myocardial infarction. Acute damage triggers robust changes spleen with rapid migration immune cells from to heart. Activating this “cardio-splenic” axis contributes progressive dysfunction. The cardio-splenic has, therefore, been identified as promising therapeutic...
A growing body of evidence shows that B-lymphocytes play an important role in the context myocardial physiology and adaptation to injury. However, literature reports contrasting data on prevalence B-cells. B-cells have been reported be both among most prevalent immune cells rodent heart or present, but at a markedly lower than myeloid cells, quite rare. Similarly, several groups described number increases after acute ischemic injury, one group no changes injured myocardium. Implementation...
ABSTRACT Introduction Growing evidence from animal models indicates that the myocardium hosts a population of B cells play role in development cardiomyopathy. However, there is minimal data on human myocardial context Methods We integrated single-cell and single-nuclei datasets 45 healthy hearts, 70 hearts with dilated cardiomyopathy (DCM), 8 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC). Interactions between other cell types were investigated using CellChat Package. Differential...
Background The response of solid tumors such as papillary thyroid cancer (PTC) to immune checkpoint inhibitors (ICIs) is highly variable. biological basis this variability remains unknown. Methods To test the hypothesis that preconditioning system modulates therapeutic effect ICIs, we used a murine model where PTC and iodine exacerbated thyroiditis (IET) can be induced in temporally predictable fashion. A total 122 mice were divided into 3 experimental groups. In first one, named concomitant...
A growing body of evidence shows that B-lymphocytes play an important role in the context myocardial physiology and adaptation to injury. However, literature reports contrasting data on prevalence B-cells. B-cells have been reported be both among most prevalent immune cells rodent heart or present, but at a markedly lower than myeloid cells, quite rare. Similarly, several groups described number increases after acute ischemic injury, one group no changes injured myocardium. Implementation...
Cardiovascular disease remains the leading cause of death worldwide. A primary driver cardiovascular mortality is ischemic heart failure, a form cardiac dysfunction that can develop in patients who survive myocardial infarction. Acute damage triggers robust changes spleen with rapid migration immune cells from to heart. Activating this "cardio-splenic" axis contributes progressive dysfunction. The cardio-splenic has, therefore, been identified as promising therapeutic target prevent or treat...
Introduction: Acute myocardial infarction (MI) induces splenic remodeling and rapid mobilization of immune cells from the spleen to injured myocardium. Activation this “cardio-splenic” axis contributes adverse cardiac development chronic heart failure. B account for majority cells, but their potential role within cardio-splenic failure remains incompletely explored. In study, we provide evidence indicating that play an essential via MHC II-mediated antigen presentation. Methods Results: MI...
Inspirée par les travaux de plusieurs cliniciens et chercheurs, l'article, qui s'appuiera aussi sur mon expérience professionnelle, portera facteurs protection permettent développer renforcer la résilience. Une fois le concept décrit, caractéristiques individuelles, familiales environnementales, constituent autant portes d'entrée pour cultiver résilience, seront présentées. Des moyens afin d'accroître des pistes d'intervention également proposés. Au terme lecteurs devraient être en mesure...
Abstract Background: The pathophysiology of peripartum cardiomyopathy (PPCM) and its defining features when compared to other forms remain unclear, thus limiting the development targeted therapies. Methods: To address this knowledge gap, we utilized a systems biology approach performed high-throughput aptamer-based proteomic analysis (SOMAscan 7K) serum samples from women with PPCM (n = 67) or non-peripartum (NPCM, n 31), age-matched healthy 10 each). Samples were obtained Investigation in...
Introduction: The role of B-cells in human heart failure remains unclear. To address this knowledge gap, we analyzed publicly available datasets scRNAseq and snRNAseq from patients with various forms cardiomyopathy. Methods Results: We used two public including single cells or nuclei RNAseq data collected the myocardium arrhythmogenic right ventricular cardiomyopathy (ARVC), dilated (DCM), idiopathic cardiac diseases (ICD), healthy controls. first dataset comprised 30 controls 22...
Introduction: Investigations in murine models have identified myocardial B cells with a characteristic gene expression signature and pointed at as promising target to develop novel therapies for heart failure. However, there is almost no data on the human heart. Methods Results: We performed immunostaining characterize amount distribution of hearts. In 12 healthy hearts collected autopsy, we found 1.4 ± 1.6 CD20+ per high power field. The number CD3+ T was 20 times higher (26.8 28.6,...