The aim of this pilot study was to identify proteins associated with advancement colon cancer (CC).A quantitative proteomics approach used determine the global changes in proteome primary from patients non-cancer normal (NC), non-adenomatous polyp (NAP), non-metastatic tumor (CC NM) and metastatic M) tissues, up- down-regulated proteins. Total protein extracted each biopsy, trypsin-digested, iTRAQ-labeled resulting peptides separated using strong cation exchange (SCX) reverse-phase (RP)...

Aim of Study Effusion cytology is a test used to determine the etiology disease. Pleural, ascitic, pericardial, synovial, and cerebrospinal fluid are commonly analyzed samples. When malignancy detected in effusions, place origin cannot be determined merely by cytologic appearance. In era advanced technology, cytomorphology alone insufficient, hence, immunocytochemistry most widely modality effusion. Application judicious immunopanel can help metastatic tumor, hence aiding clinician...

Objective: Among prostate cancer patients, the Gleason score is associated with adverse clinical outcomes. We aimed to determine whether cribriform architecture in patients without a history of treatment was related prognosis pattern 4 cancer.  Material and Methods: A prospective cross-sectional study included (n=450) consecutive biopsy specimens between June 2014 May 2015, out which (n=237) had adenocarcinoma. Demographic, clinical, follow-up details were obtained. Patients (n = 86)...

Objective: Adenoid cystic carcinoma and polymorphous adenocarcinoma are primarily the tumor of minor salivary glands. Both show certain morphological similarities, which limit their proper diagnosis in settings where there obscuring factors limited biopsy material. However, is a considerable difference treatment prognosis, raises need to distinguish these two entities. In this study, we discuss utility immunohistochemical stains, p63 p40, different combinations for distinguishing from...

The aim of the study is to identify cornulin (CRNN) protein expression associated with advancement tongue squamous cell carcinoma (TSCC). A comparison addictive (containing potential carcinogens) versus non-addiction causative agents was expected allow detection differences in CRNN TSCC. Bespoke tissue microarrays (TMAs) were prepared and immunohistochemistry (IHC) performed determine changes epithelial cells node-negative (pN-), node-positive (pN+) TSCC non-cancer patients' oral tissues....

Background Glomerulonephritis is among the most common and serious non-communicable diseases in world, some of them are major causes chronic kidney disease, which eventually leads to failure. In developing countries, it cause end-stage renal disease (ESRD). Chronic affects 10-16% adult population Asia, including 21.2% Pakistan. This study aims determine frequency spectrum glomerulonephritis at our center. Methodology a cross-sectional analysis 81 core biopsies obtained between August 2020...

Background The term triple-negative breast cancer (TNBC) refers to a particular class of aggressive, poorly differentiated neoplasms that show the absence estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) antibodies. SOX10 (SRY-related HMG-box 10) is nuclear transcription commonly used identify cancers neural origin, but it has recently been linked TNBC. purpose this study determine expression in TNBC, its association with tumor grade for molecular...

The Calcifying Epithelial Odontogenic Tumor (CEOT) is a benign odontogenic tumor, comprising approximately 1% of all tumors. It presents as slow-growing tumor in posterior mandibular region. A three year-old female child from Multan, reported swelling right lower jaw progressively increasing size eventually causing facial asymmetry. On intraoral examination, protuberance was seen arising region and displacement overlying teeth. cystic on palpation mildly tender. patient underwent complete...

Paragangliomas (PGs) are rare tumors that most commonly occur in the head and neck region along sympathetic chain. Fine-needle aspiration cytology is not used for diagnosis of PG due to potential risk hemorrhage hypertensive crisis. As a result, limited studies describe cytological features PGs. In this case series, we will discuss fine-needle three cases extra-adrenal The cellular arrangement smears was either singly scattered or loosely cohesive clusters. cells were polygonal with...

We present the case of a 36-year-old female who visited OPD local hospital in Lahore, Pakistan, with history chest pain, shortness breath and palpitations. Echocardiogram transesophageal echocardiography revealed right ventricular outflow tract mass, dilated coronary sinus atrial septal defect. Surgery was advised, successful excision mass done specimen later sent to Chughtai Institute Pathology for histopathological evaluation diagnosis. The results benign thyroid tissue no evidence...

Salivary gland tumors are an important group of neoplasms in the head and neck region. This study aims to assess significance β-catenin expression both benign malignant salivary tumors.

Introduction Helicobacter pylori (H. pylori) infection is the most common cause of gastritis. The consequences persistent range from acute ulceration to development gastric neoplasia. purpose study determine histopathological pattern gastritis in biopsies and its association with H. pylori. Materials methods This a retrospective all received Department Histopathology, Chughtai Institute Pathology, Lahore, Pakistan January 12, 2021 April 10, 2021. Sections were cut formalin-fixed,...

Abstract
 Lhermitte-Duclos disease (LDD) is a relatively uncommon condition of the cerebellum. It generally characterised as hamartomatous lesion posterior fossa and common in third fourth decades life. According to World Health Organisation, it classified grade I tumour with potential for recurrence. Otherwise, this associated good prognosis. Malignant transformation LDD has not yet been reported. However, genetic counselling patient recommended active surveillance. Since believed be...

Ganglionic cysts are common swellings of the hands. Various mechanisms thought to generate these lesions, such as cystic mucoid degeneration and inflammation. Typically, ganglionic asymptomatic but can cause pain. They usually originate from soft tissues like ligaments, joint capsules, sheaths tendons. We present case a 37-year-old man with mid-thigh swelling intermittent mild However, no systemic symptoms fever or weight loss were present. Workup unmasked presence rare intratendinous cyst....

Introduction: Asian developing countries share the burden of colorectal cancer (CRC) with rising mortality rates. This prospective study aims to apprehend clinical relevance age, gender, lifestyle choices (dietary habits and addiction), body mass index (BMI) occurrence progression colon (CC). Methods: A cohort non-cancer CC patients South-Central origin registered for screening colonoscopy or surgery at Shaukat Khanum Memorial Cancer Hospital Research Centre (SKMCH&RC), Lahore, Pakistan,...

Background High-grade B-cell lymphomas (HGBLs), with c-Myc, Bcl2, and/or Bcl6 rearrangement, are aggressive neoplasms poor clinical outcomes. Cyclin D1 is a proto-oncogene that generally expressed by mantle cell lymphoma, its variants, and many other neoplasms. Aim The aim of this study to investigate the expression frequency cyclin in HGBL association double expressor triple lymphomas. A few pieces research have been reported on triple-hit renaming it quadruple-hit lymphoma. In present...

Invasive micropapillary carcinoma and Solid papillary carcinomas are rare histologic subtypes of breast cancer. Co-existence tumors the like invasive ductal lobular carcinomas, or mucinous have been reported before. But existence with solid is a occurrence. Here, we reporting case 60-year-old female mass in her left breast. The histopathology report showed tumor containing these two subtypes. Recognition all necessary, as this can impact treatment strategy.

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of with varying biological, functional, and clinical characteristics that develop from the gastroenteropancreatic tract's diffuse system. The objective this study is to determine clinicopathological features GEP-NETs at our facility.A cross-sectional analysis 87 biopsies resection specimens January 2020 2022 was performed. histopathological reports as well patient's demographic clinic pathological data were...

Pilomatricomas are rare skin tumors related to hair follicles. They typically present in children, and the most common locations head neck. usually painless; however, they can cause cosmetic problems. Treatment is decided on an individual basis involves local excision. However, caution should be taken if lesion malignant, as resection with safe margins (0.5-1.0 cm) determinant of overall outcome. Radiotherapy indicated cases residual tumor tissue or recurrence. The role chemotherapy...