The new AJCC staging system (8th edition) incorporates depth of invasion to stage oral cancers. It is a recognized predictor for neck nodal metastasis and local recurrence, the associated risk not well defined. aim this study was explore occult recurrence in relation early squamous cell carcinoma tongue.We have evaluated records 179 patients with tongue cancer treated our unit from 2006-2015 mean age 57.92 ± 11.93 years. Treatment modalities used were surgery (26%), followed by radiotherapy...

The submental flap provides an alternative technique in orofacial reconstruction, especially situations where free services are not available. objective of this study is to demonstrate the oncological safety and benefits oral cavity reconstruction a tertiary care cancer hospital.A total 27 patients with cancers, which underwent from 2015 2017 at Shaukat Khanum Cancer Memorial Hospital, were included study. We have retrospectively reviewed records these patients.There 25 male 2 female age...

Adnexal tumors of the skin are a large and diverse group benign malignant neoplasms, which exhibit morphological differentiation toward one different types adnexal epithelium present in normal they pose diagnostic challenge. The purpose this study is to share our experience with these rare but aggressive at tertiary care cancer hospital developing country. A retrospective review 11 patients diagnosed their variants from January 2005 December 2014, treated either surgically or non-surgically,...

Abstract Objective This study aimed to estimate the prevalence of pain among treatment‐naïve patients with oral cancer and identify clinical histopathological characteristics associated occurrence. Materials Methods A retrospective chart review was conducted presenting biopsy‐proven between January 2015 December 2019. Variables, including demographic data, medical history, presentation, information, were extracted analyzed. Appropriate descriptive analytic statistics computed. Results Among...

Concurrent chemo-radiation (CRT) has been established as the standard of care for non-metastatic loco-regionally advanced nasopharyngeal carcinoma (NPC) but recently addition induction chemotherapy in already regimen presented an attractive multidisciplinary approach. This retrospective study was carried out to evaluate efficacy (IC) followed by CRT management NPC. Between July 2005 and September 2010, 99 patients were treated with cisplatin based IC CRT. Induction included a 2 drug...

Despite being rare in incidence, malignant tumors of major salivary glands show diverse histological variation. There are limited data on gland tumor management and outcome from Pakistan. The objective this study was to share our experience with glands.Patients who received treatment at Shaukat Khanum Cancer Hospital Research Center July 2002 June 2011 an underlying diagnosis a malignancy were included. Patient characteristics modalities assessed. Local, regional distant failures determined....

Aim . To share experience with regional failures after selective neck dissection in both node negative and positive previously untreated patients diagnosed squamous cell carcinoma of the oral cavity. Patients Methods Data 219 who underwent SND at Shaukat Khanum Cancer Hospital from 2003 to 2010 were retrospectively reviewed. Patient characteristics, treatment modalities, assessed. Expected 5-year control was calculated prognostic factors determined. Results Median follow-up 29 (9–109)...

Recently a sub-population of cells with stem cell characteristics, reported to be associated initiation, growth, spread and recurrence, has been identified in several solid tumors including oral tongue squamous carcinoma (OTSCC). The aim our pilot study was isolate CD44+ cancer from primary cultures OTSCC neck node Level I (node-I) biopsies, grow spheres observe their characteristics cultures. Parallel hyperplastic lesions (non-cancer) were set up as control. Immunohistochemistry used detect...

Abstract Background Early laryngeal cancer treated with definitive radiotherapy or surgery has a high cure rate. This study evaluated the patterns of treatment failure and long-term results early cancers radiotherapy. Method From January 2002 to December 2014, total 242 patients early-stage were radical Results All had squamous cell carcinoma larynx (92 per cent male 8 female). Median follow-up was 4.5 years. The majority smokers (57.4 cent). Local seen in 12.5 stage I 22.8 II patients....

Background Salivary gland tumors are rare salivary malignancies with resemblance to ductal breast carcinoma. We have described clinicopathological behavior and treatment outcomes of this malignancy. Methods duct carcinoma patients treated from 2010 2015 were retrospectively analyzed for characteristics treatment-related the disease. Results A total 12 included in study. All males mean age 52.58 ± 13.43. Parotid was most commonly involved major while buccal mucosa anterior tongue common oral...

The aim of the study is to identify cornulin (CRNN) protein expression associated with advancement tongue squamous cell carcinoma (TSCC). A comparison addictive (containing potential carcinogens) versus non-addiction causative agents was expected allow detection differences in CRNN TSCC. Bespoke tissue microarrays (TMAs) were prepared and immunohistochemistry (IHC) performed determine changes epithelial cells node-negative (pN-), node-positive (pN+) TSCC non-cancer patients' oral tissues....

Sinonasal malignancies (SNMs) are a rare and heterogeneous group of cancers with an incidence 3%-5% all head-and-neck tumours. The aim the present study was to identify characteristic features SNMs analyze treatment outcomes prognostic factors affecting it.A retrospective review patients SNM treated at dedicated cancer center Pakistan between 2004 2018 carried out. All histologically proven diagnosis malignancy arising from nasal cavity or paranasal sinuses being curative intent were...

Introduction Squamous cell carcinoma arising at the maxillary sinus is a rare neoplasm, characterized by an aggressive growth pattern and glooming prognosis. The proximity of with complex anatomical structures such as eye, skull base, infratemporal fossa, pterygomaxillary nasal cavities, ethmoid sinuses makes surgical treatment tumors infiltrating into these very challenging. study's objective was to investigate prognostic factors survival SCC outcomes. Methods We did retrospective analysis...

Introduction Development of laryngeal cancer is multifactorial, and management surrounded with controversies. Recent reports suggest a decline in the survival these patients. We conducted study to analyze clinicopathological parameters compute outcomes terms patients treated at our institution. Methods Electronic charts 515 Laryngeal Hospital Research Center from 2004 2014 were retrospectively reviewed. Results Median age was 62 years. Male: female ratio 91%: 9%. Sixty-two percent smokers....

Retromolar trigone squamous cell carcinoma is relatively uncommon and due to its complex anatomy has always remained a challenge in terms of loco-regional control survival. Surgery, radiotherapy, chemotherapy as combined modalities have been used but high recurrence rates result poor outcome.We retrospectively evaluated records 62 patients treated Head Neck Oncology unit Shaukat Khanum Memorial Cancer Hospital Research Centre (SKMCH RC), Lahore, Pakistan from 2004 2014 who were included...

Objective: The aim of this study was to compare the TNM staging system and American Thyroid Association (ATA) recurrence risk classification in predicting radioiodine refractory disease (RRD) differentiated thyroid cancer (DTC) analyze correlation stimulated thyroglobulin (Tg) levels rate Tg elevation with standardized uptake value on ¹⁸F-fludeoxyglucose (FDG) PET/CT scan. Methods: RRD indicated through retrospective analysis consecutive ¹⁸F-FDG scans DTC >10 ng/ml...

Purpose: Head and neck cancers (HNC) are among the most common in developing countries, especially Southeast Asia. Oral cavity is commonly affected site. The risk factors tobacco, betel nut alcohol. dimensions of disease quite different countries than western world. Poor socioeconomic status, poverty, lack healthcare facilities illiteracy that pose a major challenge to management disease. aim this study analyse database has been collected over period 10 years showing trends outcome these...

In resource limited settings, induction chemotherapy with Gemcitabine and Cisplatinum concurrent hypofractionated chemoradiation for locally advanced carcinoma of buccal mucosa (BMSCC) are a cost effective option but remain under reported. The objective this study was to report long term survival outcome after radiotherapy in BMSCC. Between February 2005 2009, 63 patients received treatment. Induction (IC) regimen consisted two drugs: Cisplatin. All 55 Gy radiation 20 fractions single agent...

Secretory carcinoma (SC) is an uncommon salivary gland neoplasm of the oral cavity that microscopically may mimic acinic cell (ACC) and mucoepidermoid (MEC). has been recently added in fourth edition head neck world health organization. Most these tumors are located on parotid with very few cases reported minor glands buccal mucosa. This work line SCARE criteria.A 42 years old hypertensive male, shop keeper by occupation, no prior addiction history, dental extraction or trauma, presented...