A5090974511- Autoimmune Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Pharmacological Receptor Mechanisms and Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Migraine and Headache Studies
- interferon and immune responses
- Ion channel regulation and function
- Epilepsy research and treatment
- Infectious Encephalopathies and Encephalitis
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Assays
- Toxoplasma gondii Research Studies
- Neurofibromatosis and Schwannoma Cases
- Neurological and metabolic disorders
- Spinal Cord Injury Research
- Child Abuse and Related Trauma
- Neurogenetic and Muscular Disorders Research
- Hallucinations in medical conditions
- Meningioma and schwannoma management
Texas Children's Hospital
2020-2025
Baylor College of Medicine
2020-2025
Norwegian Womens Public Health Association
2023
University of Arizona
2013-2022
Neurological Research Institute
2020
Introduction Traumatic brain injury (TBI) is a leading cause of disability in the US. Angiotensin 1-7 (Ang-1-7), an endogenous peptide, acts at G protein coupled MAS1 receptors (MASR) to inhibit inflammatory mediators and decrease reactive oxygen species within CNS. Few studies have identified whether Ang-(1-7) decreases cognitive impairment following closed TBI. This study examined therapeutic effect on secondary observed murine model mild TBI (mTBI) skull, single model. Materials methods...
We hypothesized that under chronic pain conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) in the spinal cord to promote hyperalgesia through an excitatory effect, which is opposite well-known inhibitory effect of opioid receptors. Considering structural dissimilarity between Dyn and endogenous BR ligands, (BK) kallidin (KD), this interaction could not be predicted, but it allowed us discover a potential neuroexcitatory target. Well-known BK, [des-Arg(10),...
Management of traumatic brain injury (TBI) is focused on minimizing or preventing secondary injury. Remote ischemic conditioning (RIC) an established treatment modality that has been shown to improve patient outcomes in different clinical settings by influencing inflammatory insults. In a trial, RIC showed amelioration SB100 and neuron-specific enolase. The aim our study was further elucidate the mechanisms outcome when applying mouse model injury.We subjected 100 male C57BL mice...
// Alexander J. Sandweiss 1 , Karissa E. Cottier Mary I. McIntosh Gregory Dussor 2 Thomas P. Davis Todd W. Vanderah and Tally M. Largent-Milnes Department of Pharmacology, College Medicine, University Arizona, Tucson, Arizona 85724, USA School Behavioral Brain Sciences, Texas at Dallas, Richardson, 75080, Correspondence to: Largent-Milnes, email: tlargent@email.arizona.edu Keywords: migraine; trigeminal; headache; neuroendocrine; aura Received: June 15, 2017 Accepted: November 26, Published:...
Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preference κ receptor (KOR), and its structure-activity relationship (SAR) has been extensively studied at KOR to develop selective potent agonists antagonists. Numerous SAR studies have revealed that Arg7 residue essential activity. In contrast, our systematic on [des-Arg7]Dyn analogues found not a key even deletion of does affect biological activities KOR. addition, it was also A(1-9)-NH2 minimum pharmacophore...
Anti-NMDA receptor autoimmune encephalitis (NMDAR AE) is an autoantibody-mediated disorder characterized by seizures, neuropsychiatric symptoms, movement disorder, and focal neurologic deficits. Conventionally defined broadly as inflammatory brain disease, the heterotopic localization rarely discussed in children. Imaging findings are often nonspecific, there no early biomarkers of disease other than presence anti-NMDAR antibodies.We conducted a retrospective analysis our pediatric NMDAR AE...
Several studies have suggested functional association between μ-opioid and δ-opioid receptors showed that μ-activity could be modulated by δ-ligands. The general conclusion is agonists for the δ-receptor can enhance analgesic potency efficacy of μ-agonists. Our preliminary investigations demonstrate new bivalent ligands constructed from μ-agonist fentanyl δ-agonist enkephalin-like peptides are promising entities creation analgesics with reduced side effects treatment neuropathic pain. A...
Anti-N-methyl-d-aspartate receptor autoimmune encephalitis (NMDAR AE) is an antibody-mediated neurological disorder that may be caused by post-herpes simplex virus-1 meningoencephalitis (HSV ME) and ovarian teratomas, although most pediatric cases are idiopathic. We sought to evaluate if other infections precede NMDAR AE conducting a single-center, retrospective, case-control study of 86 presenting Texas Children's Hospital between 2006 2022. HSV ME (HSV-1 HSV-2) was significantly more...
To characterize an uncommon, yet debilitating, immune-mediated demyelinating disorder of unknown etiology in three pediatric patients.
To compare the microstructural subcortical white matter changes in children with NMDAR encephalitis and grossly normal MRIs to that of age- sex-matched healthy controls.
To assess whether initial ancillary tests (brain magnetic resonance imaging-MRI, electroencephalogram-EEG, and/or cerebrospinal fluid-CSF white blood cell count) are abnormal in children with isolated psychiatric symptoms and anti-NMDA receptor encephalitis.