A5039036230- Autoimmune Neurological Disorders and Treatments
- Viral Infections and Immunology Research
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Respiratory viral infections research
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- SARS-CoV-2 and COVID-19 Research
- Genomics and Rare Diseases
- Stuttering Research and Treatment
- Cytomegalovirus and herpesvirus research
- Obsessive-Compulsive Spectrum Disorders
- Immunotherapy and Immune Responses
- Migraine and Headache Studies
- Byzantine Studies and History
- Nerve Injury and Rehabilitation
- Facial Trauma and Fracture Management
- Cardiac Structural Anomalies and Repair
- Acupuncture Treatment Research Studies
- Immune Response and Inflammation
- Bipolar Disorder and Treatment
- Epilepsy research and treatment
- Infectious Diseases and Tuberculosis
- Dental Anxiety and Anesthesia Techniques
- Infectious Encephalopathies and Encephalitis
Seattle Children's Hospital
2018-2025
University of Washington
2014-2024
Boston Children's Hospital
2018-2023
University of Virginia Health System
2023
University of Colorado Denver
2018-2023
Children's Hospital Colorado
2018-2023
Rady Children's Hospital-San Diego
2023
University of Southern California
2023
New York University
2023
Children's National
2023
Nucleic acid-sensing Toll-like receptors (TLR) 3, 7/8, and 9 are key innate immune sensors whose activities must be tightly regulated to prevent systemic autoimmune or autoinflammatory disease virus-associated immunopathology. Here, we report a systematic scanning-alanine mutagenesis screen of all cytosolic luminal residues the TLR chaperone protein UNC93B1, which identified both negative positive regulatory regions affecting TLR3, TLR7, TLR9 responses. We subsequently two families harboring...
The clinical phenotype of leucine‐rich glioma‐inactivated protein 1 (LGI1) and contactin‐associated proteinlike 2 (CASPR2) autoimmunity is well defined in adults. Data for children are limited (<10 cases). Among 13,319 pediatric patients serologically tested autoimmune neurological disorders (2010–2017), 264 were seropositive voltage‐gated potassium channel‐complex–IgG (radioimmunoprecipitation). Only 13 (4.9%) positive by transfected cell‐binding assay LGI1‐IgG (n = 7), CASPR2‐IgG 3), or...
To determine the safety, tolerability, and efficacy of fluoxetine for proven or presumptive enterovirus (EV) D68-associated acute flaccid myelitis (AFM).A multicenter cohort study US patients with AFM in 2015-2016 compared serious adverse events (SAEs), effects, outcomes between fluoxetine-treated untreated controls. Fluoxetine was administered at discretion treating providers data gathered retrospectively. The primary outcome change summative limb strength score (SLSS; sum Medical Research...
Enterovirus D68 (EV-D68) is associated with a broad spectrum of illnesses, including mild to severe acute respiratory illness (ARI) and flaccid myelitis (AFM). Enteroviruses, EV-D68, are typically detected in the United States during late summer through fall, year-to-year fluctuations. Before 2014, EV-D68 was infrequently reported CDC (1). However, numbers detection have increased recent years, biennial pattern observed 2014-2018 States, after expansion surveillance wider availability...
<h3>Objectives</h3> How brain MRI lesions associate with outcomes in pediatric anti-NMDA receptor encephalitis (pNMDARE) is unknown. In this study, we correlate T2-hyperintense clinical pNMDARE. <h3>Methods</h3> This was a multicenter retrospective cohort study from 11 institutions. Children younger than 18 years pNMDARE were included. One-year assessed by the modified Rankin Score (mRS) good (mRS ≤2) and poor ≥3) outcomes. <h3>Results</h3> A total of 175 subjects included, 1-year mRS...
In October 2016, Seattle Children's Hospital notified the Washington State Department of Health (DOH) and CDC a cluster acute onset limb weakness in children aged ≤14 years. All patients had distinctive spinal lesions largely restricted to gray matter detected by magnetic resonance imaging (MRI), consistent with flaccid myelitis (AFM). On November 3, DOH issued health advisory local jurisdictions requesting that care providers report similar cases. By January 24, 2017, confirmed 10 cases AFM...
Deubiquitination is crucial for the proper functioning of numerous biological pathways, such as DNA repair, cell cycle progression, transcription, signal transduction and autophagy. Accordingly, pathogenic variants in deubiquitinating enzymes (DUBs) have been implicated neurodevelopmental disorders congenital abnormalities. ATXN7L3 a component DUB module Spt-Ada-Gcn5 acetyltransferase (SAGA) complex two other related modules, it serves an obligate adaptor protein three ubiquitin-specific...
A 55-year-oldmanwas slowly recovering from a flulike illness but stoppedrespondingtohis family’s telephonecalls.Paramedics found him confused and naked in his home. On arrival at the local hospital, he was aphasic noncooperative. He declined neurologically over following week. had 2 seizures, required intubation, andwas transferred to our intensive care unit. His physical examinationwas notable for coma, extensor posturing, diffuse hyperreflexia. Moderate pleocytosiswas cerebrospinal...
To assess whether initial ancillary tests (brain magnetic resonance imaging-MRI, electroencephalogram-EEG, and/or cerebrospinal fluid-CSF white blood cell count) are abnormal in children with isolated psychiatric symptoms and anti-NMDA receptor encephalitis.
<h3>Objective:</h3> To correlate MRI brain lesions with clinical outcomes in pediatric anti-NMDA receptor encephalitis (pNMDARE). <h3>Background:</h3> Up to 50% of MRIs NMDARE are reportedly abnormal. However, data is limited on range and types abnormalities, also how abnormal associate pNMDARE. <h3>Design/Methods:</h3> This was a multi-center retrospective cohort study ten institutions. defined as positive CSF NMDA-receptor antibody at least one neuropsychiatric symptom. Patients prior HSV...
Acute flaccid myelitis (AFM) is a polio-like condition predominantly affecting children that characterized by acute-onset, asymmetric paralysis, often preceded prodromal fever or viral illness. With prompt diagnosis and early surgical referral, nerve transfers may be performed to improve function. Highly selective are ideal preserve existing functions while targeting specific deficits. In this report, we present case of double fascicular transfer median ulnar fascicles the axillary nerve,...
Most patients with enterovirus (EV) D68-associated acute flaccid myelitis (AFM) have long-term disability. No effective therapies been identified. Fluoxetine is the only FDA-approved medication in vitro antiviral activity against EV-D68. This study retrospectively analyzed safety, tolerability, and efficacy of fluoxetine for EV-D68-associated AFM. A multicenter cohort US children AFM 2015–2016 compared serious adverse events (SAEs), effects, outcomes between fluoxetine-treated untreated...
"The Synodicum Nicosiense and other Documents of the Latin Church Cyprus, 1196–1373, selected trans. by Christopher Schabel (Texts Studies in History Cyprus 39). Nicosia: Research Centre, 2001. Pp. 393. ISBN 9963 0 8073 1.." Crusades, 3(1), pp. 199–200
A 17-year-old girl with a history of depression was referred by her psychologist to the emergency department (ED) because concerning behavioral changes for past 2 weeks. She engaging in erratic behaviors, including excessive baking, handling broken glass, mixing chemicals, and swimming alone while clothed. denied any intention harm herself or others. feeling energized morning despite only sleeping few hours at night. also urinated on day before ED visit. Her examination preliminary testing...