Julian A. Yano

ORCID: 0000-0002-5134-8782
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About
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Research Areas
  • Immune Response and Inflammation
  • Immunotherapy and Immune Responses
  • Distributed and Parallel Computing Systems
  • interferon and immune responses

University of California, Berkeley
2024

Victoria E. Rael Julian A. Yano John Huizar Leianna C. Slayden Madeleine A. Weiss and 95 more Elizabeth A. Turcotte J M Terry Wenqi Zuo Isabelle Thiffault Tomi Pastinen Emily Farrow Janda Jenkins Mara L. Becker Stephen C. Wong Anne M. Stevens Catherine Otten Eric J. Allenspach Devon Bonner Jonathan A. Bernstein Matthew T. Wheeler Robert A. Saxton Maria T. Acosta David R. Adams Raquel L. Alvarez Justin Alvey Aimee Allworth Ashley Andrews Euan A. Ashley Ben Afzali Carlos A. Bacino Güney Bademci Ashok Balasubramanyam Dustin Baldridge Jim Bale Michael J. Bamshad Deborah Barbouth Pınar Bayrak‐Toydemir Anita Beck Alan H. Beggs Edward M. Behrens Gill Bejerano Hugo J. Bellen Jimmy Bennett Jonathan A. Bernstein Gerard T. Berry Anna Bican Stephanie Bivona Elizabeth Blue John Bohnsack Devon Bonner Lorenzo D. Botto Lauren C. Briere Gabrielle Brown Elizabeth A. Burke Lindsay C. Burrage Manish J. Butte Peter H. Byers William E. Byrd John M. Carey Thomas Cassini Sirisak Chanprasert Hsiao‐Tuan Chao Iván K. Chinn Gary Clark Terra R. Coakley Laurel A. Cobban Joy D. Cogan Matthew Coggins F. Sessions Cole Heather A. Colley Rosario I. Corona William J. Craigen Andrew B. Crouse Michael L. Cunningham Precilla D’Souza Hongzheng Dai Surendra Dasari Joie Davis Jyoti G. Dayal Margaret Delgado Esteban C. Dell’Angelica Katrina M. Dipple Daniel Doherty Naghmeh Dorrani Argenia L. Doss Emilie D. Douine Dawn Earl David J. Eckstein Lisa Emrick Christine M. Eng Marni J. Falk Elizabeth L. Fieg Paul G. Fisher Brent L. Fogel Jiayu Fu William A. Gahl I. S. Glass Pagé C. Goddard Rena A. Godfrey Andrea Gropman

Nucleic acid-sensing Toll-like receptors (TLR) 3, 7/8, and 9 are key innate immune sensors whose activities must be tightly regulated to prevent systemic autoimmune or autoinflammatory disease virus-associated immunopathology. Here, we report a systematic scanning-alanine mutagenesis screen of all cytosolic luminal residues the TLR chaperone protein UNC93B1, which identified both negative positive regulatory regions affecting TLR3, TLR7, TLR9 responses. We subsequently two families harboring...

10.1084/jem.20232005 article EN cc-by The Journal of Experimental Medicine 2024-05-23
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