Michael R. Sutherland

ORCID: 0000-0002-8242-4258
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About
Contact & Profiles
Research Areas
  • Primate Behavior and Ecology
  • Blood Coagulation and Thrombosis Mechanisms
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Amphibian and Reptile Biology
  • Evolution and Paleontology Studies
  • Herpesvirus Infections and Treatments
  • Mosquito-borne diseases and control
  • Platelet Disorders and Treatments
  • Viral Infections and Vectors
  • Parvovirus B19 Infection Studies
  • Morphological variations and asymmetry
  • Animal Behavior and Reproduction
  • Animal Vocal Communication and Behavior
  • Wildlife Ecology and Conservation
  • Species Distribution and Climate Change
  • Systemic Lupus Erythematosus Research
  • Protease and Inhibitor Mechanisms
  • Urticaria and Related Conditions
  • Isotope Analysis in Ecology
  • Virology and Viral Diseases
  • Virus-based gene therapy research
  • Vibrio bacteria research studies
  • HIV Research and Treatment
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Human-Animal Interaction Studies

Canadian Blood Services
2009-2024

University of British Columbia
2007-2024

University of Massachusetts Amherst
2002-2020

New College of Florida
2016

Center for Innovation
2014

University of Pennsylvania
2004

University of Ottawa
1996-2003

Leiden University
2000

National Institute of Nursing Research
2000

National Institutes of Health
2000

Abstract Many users of regression methods are attracted to the notion that it would be valuable determine relative importance independent variables. This article demonstrates a method based on hierarchies builds previous efforts decompose R 2 through incremental partitioning. The standard partitioning has been follow one order among many possible orders available. By taking hierarchical approach in which all variables used, average contribution variable is obtained and an exact results. Much...

10.1080/00031305.1991.10475776 article EN The American Statistician 1991-05-01

Scatter diagrams have historically proved useful in the study of associative relationships ecology. Several important ecological questions involve correlations between variables resulting polygonal shapes. Two examples that received considerable attention are patterns prey size and predator animal populations relationship abundance body size. Each is typically illustrated using scatter with upper lower boundaries response often changing at different rates changes independent variables....

10.1890/0012-9658(1998)079[0448:ierfte]2.0.co;2 article EN Ecology 1998-03-01

How, when, and from where Madagascar's vertebrates arrived on the island is poorly known, a comprehensive explanation for distribution of its organisms has yet to emerge. We begin break that impasse by analyzing vertebrate arrival patterns implied currently existing taxa. For each 81 clades, we compiled date, source, ancestor type (obligate freshwater, terrestrial, facultative swimmer, or volant). analyzed changes in rates, with without adjusting clade extinction. Probability successful...

10.1073/pnas.1113993109 article EN Proceedings of the National Academy of Sciences 2012-03-19

Analyses of phylogenetic topology and estimates divergence timing have facilitated a reconstruction Madagascar's colonization events by vertebrate animals, but that information alone does not reveal the major factors shaping island's biogeographic history. Here, we examine profiles Malagasy clades through time within context paleogeographical evolution to determine how particular influenced arrival extant groups. First compare on Madagascar before after selected events; then tetrapod...

10.1371/journal.pone.0062086 article EN cc-by PLoS ONE 2013-04-23

This paper explores the correlates of variation in dental development across order Primates. We are particularly interested how 1) precocity (percentage total postcanine primary and secondary teeth that have erupted at selected absolute ages life cycle stages) 2) endowment weaning adult occlusal area is present weaning) related to body or brain size diet primates. ask whether folivores more accelerated schedules than do like-sized frugivores, if so, what extent this part parcel a general...

10.1002/1096-8644(200103)114:3<192::aid-ajpa1020>3.0.co;2-q article EN American Journal of Physical Anthropology 2001-01-01

Salt marsh ecosystems have been considered not susceptible to nitrogen overloading because early studies suggested that salt marshes adsorbed excess nutrients in plant growth. However, the possible effect of nutrient loading on species composition, and combined effects altered composition structure function, was largely ignored. Failure understand interactions between may lead severe underestimates impacts stresses. We whole (∼60 000 m 2 /treatment) by addition flooding waters reduction a...

10.1890/06-0452.1 article EN Ecological Applications 2007-07-01

The research described in this article has set out to determine the extent which lean thinking is being adopted as a manufacturing philosophy by process industries. It concerns application and examination of key principles, namely, alignment production with demand, elimination waste, integration suppliers (IS) creative involvement workforce improvement activities, range industry types based on Dennis Meredith's taxonomy transformation systems [Dennis, D. Meredith, J., 2000a. An empirical...

10.1080/09537287.2011.633576 article EN Production Planning & Control 2011-11-14

Abstract There is a well‐documented relationship between development and other life‐history parameters among anthropoid primates. Smaller‐bodied anthropoids tend to mature more rapidly than do larger‐bodied species. Among of similar body sizes, folivorous species grow quickly frugivorous species, thus attaining adult size at an earlier age. This pattern conforms the expectations Janson van Schaik's “ecological risk aversion hypothesis,” which predicts that rates growth maturation should vary...

10.1002/ajpa.10315 article EN American Journal of Physical Anthropology 2003-07-07

Researchers are divided about the relative importance of people versus climate in triggering Late Holocene extinctions endemic large‐bodied fauna on island Madagascar. Specifically, a dramatic and synchronous decline arboreal pollen increase grass ca 1000 yr ago has been alternatively interpreted as evidence for aridification, increased human activity, or both. As aridification anthropogenic deforestation can have similar effects vegetation, resolving which these factors (if either) led to...

10.1111/ecog.02376 article EN Ecography 2016-05-12

Herpesviruses have been previously correlated to vascular disease and shown cause thrombogenic atherogenic changes host cells. Herein we show that even in the absence of cells, purified cytomegalovirus (CMV) herpes simplex virus type 1 (HSV-1) 2 (HSV-2) can initiate thrombin production. Functional assays demonstrated HSV-1 HSV-2 provide necessary phospholipid (proPL) for assembling coagulation factors Xa Va into prothrombinase, which is responsible generating thrombin. These observations are...

10.1073/pnas.94.25.13510 article EN Proceedings of the National Academy of Sciences 1997-12-09

Recently it was reported that limb joint surface areas scale positively allometrically with body weight in anthropoid primates. This attributed to the biomechanics of bearing: larger animals must require relatively surfaces withstand greater weight‐related stresses on joints. Our data humeral and femoral geometry 73 species belonging six mammalian orders (including primates) demonstrate positive allometry is not a general phenomenon for mammals cannot have its basis among Anthropoidea...

10.1111/j.1469-7998.1991.tb04391.x article EN Journal of Zoology 1991-04-01

Abstract Large body size has evolved repeatedly in the order Primates, not merely among anthropoids but also prosimians. Whereas high degrees of sexual dimorphism characterize many large‐bodied anthropoids, this is case for extinct lemurs. This paper uses finite mixture analysis and other techniques to ascertain just how much skull length might be embedded generally unimodal distributions lengths giant lemurs from single localities, then compares these results with known dimorphisms extant...

10.1002/ajpa.1330900306 article EN American Journal of Physical Anthropology 1993-03-01

Abstract As with juvenile wolves or coyotes, adult livestock conducting dogs displayed the first‐half segment of a functional predatory system motor patterns and did not express play social bonding toward sheep; whereas, like wolf coyote pups, protecting sequences mixed social, submissive, investigatory rarely expressed during ontogeny (even when fully adult) behaviors. The most parsimonious explanation our findings is that behavioral differences in two types are case selected differential...

10.1111/j.1439-0310.1987.tb00645.x article EN Ethology 1987-01-12

Abstract Surface areas of humeral and femoral heads scale largely as a function body size. However, differences in the relative sizes these articular surfaces are correlated with differential joint mobility force transmission through fore‐ hindlimbs. They can therefore assist interpretation positional behavior extinct species. In this paper, we document variation ratios head surface area to among extant primates other mammals. We then examine group primates: subfossil lemurs Madagascar. Many...

10.1002/ajpa.1330970103 article EN American Journal of Physical Anthropology 1995-05-01

Cell-surface annexin 2 (A2) and its ligand p11 have been implicated in fibrinolysis because of their ability to accelerate tissue plasminogen activator (tPA)-mediated activation plasmin. Because thrombin is a potent cell modulator obligately produced at the site clot formation, we hypothesized that amount cell-surface A2 might be altered by with consequent effects on plasmin generation. In support this hypothesis, immunofluorescence microscopy hydrophilic biotinylation experiments showed...

10.1242/jcs.00434 article EN Journal of Cell Science 2003-05-23
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