A5078913961- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
University of Sheffield
2022-2024
Universidad de Málaga
2022-2024
Nationwide Children's Hospital
2024
The blood-brain barrier (BBB) serves as a highly intricate and dynamic interface connecting the brain bloodstream, playing vital role in maintaining homeostasis. BBB dysfunction has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS); however, of neurodegeneration is understudied. We developed an ALS patient-derived model by using cells derived from 5 patient donors carrying C9ORF72 mutations. Brain microvascular endothelial-like (BMEC-like...