A5030515646- Plant-derived Lignans Synthesis and Bioactivity
- Bioactive Compounds and Antitumor Agents
- Axial and Atropisomeric Chirality Synthesis
- Bioactive Natural Diterpenoids Research
- Synthesis and Reactions of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Hepatitis B Virus Studies
- Plant-based Medicinal Research
- Synthesis of Organic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Viral Infections and Outbreaks Research
- Oxidative Organic Chemistry Reactions
- Synthesis and biological activity
- Traditional and Medicinal Uses of Annonaceae
- Toxin Mechanisms and Immunotoxins
- Herbal Medicine Research Studies
- Phytochemistry and Biological Activities
- Mosquito-borne diseases and control
- Biochemical Acid Research Studies
Hong Kong Baptist University
2017-2023
Arylnaphthalene lignans (ANLs) were known to have axial chirality due the biphenyl skeleton with hindered rotation at single bond. However, stable ANL atropisomers not been isolated from nature until present study. Phytochemical separation of methanol extract stems and barks
Ebola virus disease (EVD), a caused by infection with (EBOV), is characterized hemorrhagic fever and high case fatality rate. With limited options for the treatment of EVD, anti-Ebola viral therapeutics need to be urgently developed. In this study, over 500 extracts medicinal plants collected in Lingnan region were tested against Ebola-virus-pseudotyped particles (EBOVpp), leading discovery Maesa perlarius as an anti-EBOV plant lead. The methanol extract (MPBE) stems showed inhibitory effect...
Background: Avian influenza, commonly known as bird flu, is caused by viruses adapted to birds; however, some of the avian are highly pathogenic human population. Though vaccines have been developed for prevention emerging resistant strains greatly limit effectiveness these mainstay prophylactic drugs. Thus, novel anti-avian influenza agents sought dissemination such resistance crisis. Plants in great biological diversities stand infinite resources development anti-influenza agents....
Three isopimarane diterpenes [fladins B (1), C (2), and D (3)] were isolated from the twigs leaves of Chinese folk medicine, Isodon flavidus. The chemical structures determined by analysis comprehensive spectroscopic data, absolute configuration was confirmed X-ray crystallographic analysis. 1-3 formed isopimaranes through rearrangement ring A bond break at C-3 C-4 to form a new δ-lactone system between C-9. This structure type represents first discovery natural diterpene with an unusual...
Abstract One of the structural uniqueness arylnaphthalene lignans (ANLs) is their potential atropoisomerism, which may result in bioactivity discrepancy. However, stable ANL atropisomers rarely exist nature. In course our phytochemical study Justicia procumbens , we isolated nine glycosides ( 1 – 9 ) with four them 4 being identified as new atropisomers. Their absolute configurations were determined based on analysis circular dichroism (CD) and electronic (ECD) data. The compounds evaluated...
Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3-6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures deduced based on detailed spectroscopic analysis. All isolates displayed cytotoxic effects against A549 human tumor cell lines IC50 values ranging 1.318 to 7.042 μM.