A5073903509- Neonatal Respiratory Health Research
- Single-cell and spatial transcriptomics
- Congenital Diaphragmatic Hernia Studies
- Extracellular vesicles in disease
- Photosynthetic Processes and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Renal and related cancers
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Plant Gene Expression Analysis
- Respiratory viral infections research
- Biomedical Ethics and Regulation
- Plant Stress Responses and Tolerance
- Virus-based gene therapy research
- Congenital Anomalies and Fetal Surgery
- Cancer Cells and Metastasis
AstraZeneca (United Kingdom)
2024
Cardiff University
2024
University of Cambridge
2020-2021
Wellcome/MRC Cambridge Stem Cell Institute
2020-2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the cause of a present pandemic, infects human lung alveolar type (hAT2) cells. Characterizing pathogenesis crucial for developing vaccines and therapeutics. However, lack models mirroring cellular physiology pathology hAT2 cells limits study. Here, we develop feeder-free, long-term, three-dimensional (3D) culture technique derived from primary tissue investigate infection response to SARS-CoV-2. By imaging-based analysis...
Abstract SAG21/LEA5 is an unusual late embryogenesis abundant protein in Arabidopsis thaliana , that primarily mitochondrially located and may be important regulating translation both chloroplasts mitochondria. SAG21 expression regulated by a plethora of abiotic biotic stresses plant growth regulators indicating complex regulatory network. To identify key transcription factors expression, yeast-1-hybrid screens were used to bind the 1685 bp upstream translational start site. Thirty-three...
Abstract Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), which is the cause of a present global pandemic, infects human lung alveolar cells (hACs). Characterising pathogenesis crucial for developing vaccines and therapeutics. However, lack models mirroring cellular physiology pathology hACs limits study. Here, we develop feeder-free, long-term three-dimensional (3D) culture technique type (hAT2) cells, investigate infection response to SARS-CoV-2. By imaging-based analysis...
Abstract While the acquisition of cellular plasticity in adult stem cells is essential for rapid regeneration after tissue injury, little known about underlying molecular mechanisms governing this process. Our data reveal coordination airway progenitor differentiation by inflammatory signals during alveolar regeneration. Upon damage, IL-1β signalling-dependent modulation Jag1/2 expression ciliated results inhibition Notch signalling secretory cells, which drives reprogramming and plasticity....