A5101826094- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Toxoplasma gondii Research Studies
- Hernia repair and management
- Advanced X-ray and CT Imaging
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Plant-derived Lignans Synthesis and Bioactivity
- Intestinal and Peritoneal Adhesions
- Hepatocellular Carcinoma Treatment and Prognosis
- Parasites and Host Interactions
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- Renal cell carcinoma treatment
- Retinoids in leukemia and cellular processes
- Dermatology and Skin Diseases
- Complement system in diseases
- Ultrasound in Clinical Applications
- SARS-CoV-2 detection and testing
Korea Center for Disease Control and Prevention
2014-2020
Korea Disease Control and Prevention Agency
2014-2020
Korea National Institute of Health
2014-2020
Centers for Disease Control and Prevention
2014
Pusan National University
2009-2010
Sunchon National University
2006
Asan Medical Center
1998
University of Ulsan
1998
Seoul National University
1994
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the cause of a present pandemic, infects human lung alveolar type (hAT2) cells. Characterizing pathogenesis crucial for developing vaccines and therapeutics. However, lack models mirroring cellular physiology pathology hAT2 cells limits study. Here, we develop feeder-free, long-term, three-dimensional (3D) culture technique derived from primary tissue investigate infection response to SARS-CoV-2. By imaging-based analysis...
To evaluate the usefulness of known computed tomographic (CT) criteria for differentiation simple and strangulated small-bowel obstructions.CT scans 84 patients with (n = 43) 41) obstructions caused by adhesions, hernia, volvulus were reviewed retrospectively. Diagnoses made surgery 55) during clinical follow-up 29). CT evaluated configuration obstructed bowel loop, target sign, wall thickening enhancement, changes in mesentery mesenteric vasculature, amount attenuation ascites.CT findings...
Abstract Suppression of an excessive systemic inflammatory response is a promising and potent strategy for treating endotoxic sepsis. Indoleamine 2,3-dioxygenase (IDO), which the rate-limiting enzyme tryptophan catabolism, may play critical role in various disorders. In this study, we report IDO dysregulated immune associated with endotoxin shock. We found that knockout (IDO−/−) mice 1-methyl-d-tryptophan-treated, endotoxin-shocked had decreased levels cytokines, TNF-α, IL-6, IL-12, enhanced...
Clonorchis sinensis is currently the most important parasite affecting public health problems in Republic of Korea. We investigated prevalence C. infection among residents living along 5 major rivers A total 42,562 individual stool samples were collected from 37 localities and examined using formalin-ether sedimentation technique. Helminth eggs detected 4,052 (9.5%) 3,586 (8.4%) infected with sinensis. The egg positive rate Nakdong, Seomjin, Geum, Yeongsan, Han River was 11.7%, 9.9%, 6.5%,...
Babesiosis is an emerging tick-borne disease in humans worldwide; however, little known about the frequency of infection or prevalence this other parts world, excluding North America. In study, we aimed to investigate Babesia microti a human population Mongolia. One hundred blood samples were collected from stock farmers living Khutul city Selenge province, The sera and DNA evaluated for presence B. by using indirect fluorescent antibody (IFA) tests PCR. positive detection rates obtained IFA...
Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects humans and animals via congenital or postnatal routes, it found worldwide. Modulation of the immune system by infection proposed to suppress allergic inflammation. Growing evidences have shown interleukin (IL)-10-producing regulatory B cells (B(regs)) CD4+CD25+FoxP3+ T (T(regs)) induced play a critical role in autoimmune diseases because these regulate negatively cellular responses Currently,...
The advent of the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates a thorough study stability and transmissibility in environment. We characterized SARS-CoV-2 three water matrices: fresh, tap, seawater. minimum infective dose Vero cells was confirmed to be 10³ PFU/mL. varied according matrix: undetectable after treatment with fresh seawater, but remained detectable for days tap water, when starting an initial concentration 10⁴ When increased...
MR cholangiopancreatography of pancreaticobiliary diseases: comparing single-shot RARE and multislice HASTE sequences.M G Lee, Y K Jeong, M H Kim, S E Kang, D Chien, Shin, Ha, P N Kim AuhAudio Available | Share
Thin-section CT findings of the lungs: experimentally induced bronchial and pulmonary artery obstruction in pigs.J G Im, Y W Choi, H D Kim, K Jeong M C HanAudio Available | Share
Myristicin은 육두구에서 발견되는 고농축 정유 중 하나인 물질이다. 하지만 Th1/Th2 면역반응에서 육두구의 항알레르기 효과는 아직 밝혀지지 않았다. 최근에 전사인자로서 T-bet, GATA-3가 밝혀졌는데 이번 실험에서 myristicin이 ovalbumin(OVA)으로 유도한 천식(asthma) 생쥐모델에서 Th1,Th2 싸이토카인과 유전자 발현을 조절할 수 있는가에 대하여 알아보았다. 또한 기관지 폐포 세척액을 회수하여 백혈구의 수적 변화, 제2형 협조T세포(Th2 cell)가 생산하는 IL-4, IL-5의 생산에 미치는 영향과 폐조직에서 matrix metalloproteinase (MMP)-9 활성을 측정하였다. 그 결과 세척액에서 OVA로 감작하여 천식을 실험군에서는 호산구의 현저한 증가, Th2 형 싸이토카인(IL-4, IL-5)의 증가가 관찰되었다. 그러나 myristicin을 투여한 그룹에서는 OVA의 감작에 의하여 증가한 각종 염증성 지표들이...
The purpose of this study was to compare power Doppler sonography with conventional color for the detection vascularity hepatocellular carcinomas after transcatheter arterial chemoembolization. Of 93 embolized carcinomas, hypervascularity demonstrated in 36 on angiography; correctly identified pulsatile flow signals 33 (92%) these 36, whereas 24 (67%). A statistically significant difference noted when sizes nodules were 30 mm or less. Despite technical difficulties, such as flash artifact,...