A5076136822- Immunotherapy and Immune Responses
- Carcinogens and Genotoxicity Assessment
- Immune Response and Inflammation
- Radioactive contamination and transfer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Radiation Effects and Dosimetry
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Molecular Biology Techniques and Applications
- Tuberculosis Research and Epidemiology
- Radiation Dose and Imaging
- Sirtuins and Resveratrol in Medicine
- Cancer Research and Treatments
- Tryptophan and brain disorders
- Cytokine Signaling Pathways and Interactions
- Spaceflight effects on biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Histone Deacetylase Inhibitors Research
- Effects of Radiation Exposure
- Sepsis Diagnosis and Treatment
- NF-κB Signaling Pathways
- Phytochemistry and Bioactivity Studies
- Inflammasome and immune disorders
Dongnam Institute of Radiological & Medical Sciences
2014-2025
Dong-A University
2015-2023
Pohang University of Science and Technology
2022
Chonnam National University
2022
Korea Electric Power Corporation (South Korea)
2022
Advanced Engineering (Czechia)
2022
Korea University
2022
Inha University
2022
CHA Vaccine Institute (South Korea)
2016
Pusan National University
2009-2011
Effective activation of dendritic cells (DCs) toward T helper (Th)-1 cell polarization would improve DC-based antitumor immunotherapy, helping promote the development immunotherapeutic vaccines based on T-cell immunity. To achieve this goal, it is essential to develop effective immune adjuvants that can induce powerful Th1 responses. The pathogenic organism Mycobacterium tuberculosis includes certain constitutes, such as heparin-binding hemagglutinin (HBHA), possess a strong...
Biological dosimetry is an essential analytic method to estimate the absorbed radiation dose in human body by measuring changes biomolecules after exposure. Joint response a network mass-casualty incidents one way overcome limitations of biological dosimetry, sharing workload among laboratories. This study aimed investigate current performance, collaborative activities and technical advances Korea biodosimetry (K-BioDos), suggest future directions toward successful joint response.
Biological dosimetry is crucial for estimating the doses from biological samples and guiding medical interventions accidental radiation exposure. This study aimed to derive rapid precise dose estimates using a dicentric chromosome assay. To address challenges of manual scoring chromosomes, we upgraded an automatic system at enhancing precision detection while reducing need human intervention. We collected blood 30 individuals aged 20–67 years create dose-response curves aiming investigate...
Networking with other biodosimetry laboratories is necessary to assess the radiation exposure of many individuals in large-scale radiological accidents. The Korea network, K-BioDos, prepared harmonized scoring guidelines for dicentric chromosome assay obtain homogeneous results within network and investigated efficiency guidelines.
Background Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock. Here we present novel activities for PAF in protecting mice against LPS-mediated endotoxic Principal Findings In vivo treatment immediately after LPS challenge markedly improved the survival rate mortality from Administration of prominently attenuated LPS-induced organ injury, including profound hypotension, excessive polymorphonuclear neutrophil...
Abstract Background Typhoid, which is caused by Salmonella enterica serovar Typhimurium, remains a major health concern worldwide. Multidrug-resistant strains of have emerged exhibit increased survivability and virulence, thus leading to morbidity. However, little known about the protective immune response against this microorganism. The outer membrane protein (Omp)A bacteria plays an important role in pathogenesis. Results We purified OmpA from S. Typhimurium (OmpA-sal) characterized...
The dicentric chromosome assay (DCA), often referred to as the 'gold standard' in radiation dose estimation, exhibits significant challenges a consequence of its labor-intensive nature and dependency on expert knowledge. Existing automated technologies face limitations accurately identifying chromosomes (DCs), resulting decreased precision for estimation. Furthermore, process DCs through automatic or semi-automatic methods, distribution could demonstrate under-dispersion over-dispersion,...
Radiation is an important component of therapy for a wide range malignant conditions. However, it triggers DNA damage and cell death in normal cells results adverse side-effects. Cordyceps militaris (C. militaris), traditional medicinal mushroom, produces the bioactive compound, cordycepin (3'-deoxyadenosine) has multiple pharmacological activities, such as antitumor, antimetastatic, antioxidant immunomodulatory effects. The present study was undertaken to investigate whether CM-AE, extract...
Radiotherapy can induce the infiltration of immune suppressive cells which are involved in promoting tumor progression and recurrence. A number natural products with immunomodulating abilities have been gaining attention as complementary cancer treatments. This is partly due to therapeutic strategies proven be ineffective a result tumor‑induced immunosuppressive found microenvironment. The present study investigated whether HS‑1793, resveratrol analogue, enhance antitumor effects by...
Apicidin is a fungal metabolite shown to exhibit anti-proliferative, anti-invasive, and anti-inflammatory properties by the inhibition of histone deacetylase (HDAC). However, effects apicidin on maturation immunostimulatory function dendritic cells (DCs) remain unknown. In this study, we investigated whether modulates surface molecule expression, cytokine production, endocytosis capacity, underlying signaling pathways in murine bone marrow-derived DCs. We observed that significantly...
Abstract Despite the possibility of combining Toll-like receptor (TLR) ligands as adjuvants to improve vaccine efficacy, it remains unclear which combinations TLR are effective or what their underlying mechanisms may be. Here, we investigated mechanism action L-pampo, a proprietary adjuvant composed TLR1/2 and TLR3 ligands. L-pampo dramatically increased humoral immune responses against tested target antigens, was correlated with an increase in follicular helper T cells maintenance...
Abstract The dicentric chromosome assay is the “gold standard” in biodosimetry for estimating radiation exposure. However, its large-scale deployment limited owing to time-consuming nature and requirement expert reviewers. Therefore, a recently developed automated system was evaluated assay. A previously constructed deep learning-based automatic dose-estimation (DLADES) used construct dose curves calculate estimated doses. Blood samples from two donors were exposed cobalt-60 gamma rays (0–4...
Purpose Mutual cooperation of biodosimetry laboratories is required for dose assessments large numbers people with potential radiation exposure, as in mass casualty accidents. We launched an intercomparison exercise to validate the performance South Korea.Materials and methods Participating shared metaphase images from dicentric chromosome assays (DCAs) fluorescence situ hybridization (FISH)-based translocation assays, which were evaluated based on their own scoring protocols.Results...
The purpose of this study was to establish the dose-response curves for biological dosimetry Dong Nam Institute Radiological and Medical Sciences monitor radiation exposure local residents in vicinity nuclear power plant. blood samples five healthy volunteers were irradiated with gamma ray, each sample divided equally analysis chromosomal aberrations by Giemsa staining three-color fluorescence situ hybridization painting triplet (chromosomes #1, #2, #4). results followed Poisson distribution...
We investigated the effects of low dose rate radiation (LDR) on M1 and M2 macrophages in an ovalbumin-induced mouse model allergic airway inflammation asthma. After exposure to LDR (1 Gy, 1.818 mGy/h) for 24 days, mice were euthanized changes number bronchoalveolar lavage fluid lung, M2-associated cytokine levels, assessed. treatment not only restored M2-rich microenvironment but also ameliorated asthma-related progression a macrophage-dependent manner. In model, significantly inhibited M2,...