A5101713649- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Ion Channels and Receptors
- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Nitric Oxide and Endothelin Effects
- Oral health in cancer treatment
- Superconducting Materials and Applications
- Pharmacological Effects of Natural Compounds
- Gastroesophageal reflux and treatments
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Cancer, Stress, Anesthesia, and Immune Response
- Eicosanoids and Hypertension Pharmacology
- Ion Transport and Channel Regulation
- Receptor Mechanisms and Signaling
- Biochemical Analysis and Sensing Techniques
- Eosinophilic Esophagitis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Herbal Medicine Research Studies
- Diet and metabolism studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Respiratory and Cough-Related Research
Kyoto Pharmaceutical University
2015-2024
Kogakuin University
2024
Yasuda Women's University
2024
Okayama University
2024
Bioscience Research
2024
Tohoku University
1992-2024
The University of Tokyo
2024
Kansai Rosai Hospital
2016
Japan Atomic Energy Agency
2012-2016
Gunma University
2016
The chemotherapeutic agent 5-fluorouracil (5-FU) causes intestinal mucositis with severe diarrhoea, but the pathogenesis is not fully understood. In this study, we investigated pathogenic effects of 5-FU in mice, focusing on apoptosis, enterobacteria and inflammatory cytokines. Repeated administration caused day 6, accompanied by diarrhoea body-weight loss. TNF-α expression increased 1 after exposure to drug, spiked a second time 4, at which point myeloperoxidase activity IL-1β also...
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin produce damage in the small intestine a major adverse reaction. We examined effect of various NSAIDs on intestinal motility and investigated pathogenic importance changes ulcerogenic response to rats.Animals without fasting were given (indomethacin 10 mg/kg, diclofenac 40 flurbiprofen 20 naproxen mg/kg) s.c., case indomethacin, following parameters 24 h later; lesion score, number enterobacteria myeloperoxidase (MPO) well...
Chemotherapeutic agents, including 5-fluorouracil (5-FU), frequently cause intestinal mucositis resulting in severe diarrhoea and morphological mucosal damage. 5-HT₃ receptor antagonists are clinically effective the treatment of nausea emesis during cancer chemotherapy. Therefore we here have examined effects on 5-FU-induced mice.Intestinal was induced male C57BL/6 mice by daily administration 5-FU (50 mg·kg⁻¹) for 5 days. Effects antagonists, ramosetron (0.01-0.1 ondansetron (5 mg·kg⁻¹),...
テトラリンの自動酸化に対する各種酸化チタンの光触媒活性を定量的に比較した。酸化チタンの共存下,紫外線照射により, テトラリンの酸化は顕著に促進され, かつその光触媒作用は温度に影響されず, また長期にわたってほぼ一定である。光触媒活性は,酸化チタンの種別によっては広範囲に変化し,その原因は表面積,格子欠陥,異種元素による障害などの諸因子の重複に帰せられる。動力学的解析により,テトラリンの酸化機構はBolland-Geeの形式にしたがい,反応速度は自動酸化の一般的速度式で表現できることが示された。動力学的知見に基づいて酸化チタンの光触媒過程およびテトラリンの酸化機構を論じた。
Bifidobacterium, a major component of the intestinal microbiota, has been clinically used for treatment diarrhoea and constipation. 5-Fluorouracil (5-FU), widely cancer chemotherapy, is known to frequently induce mucositis accompanied by severe diarrhoea. The present study examined effect Bifidobacterium bifidum G9-1 (BBG9-1) on 5-FU-induced in mice. Intestinal was induced repeated administration 5-FU 6 days. BBG9-1 administered orally once daily 9 days, beginning 3 days before onset...
Clinical chemotherapy frequently causes intestinal mucositis as a side effect, which is accompanied by severe diarrhea. We recently showed that the cytokine-mediated apoptotic pathway might be important for development of induced 5-fluorouracil (5-FU). Saireito, traditional Japanese herbal (Kampo) medicine, widely used to treat diarrhea and various inflammatory diseases in Japan. In present study, we investigated effect saireito on 5-FU-induced mice, especially relation apoptosis crypt. Male...
5-HT (serotonin) regulates various physiological functions, both directly and via enteric neurons. The present study investigated the role of endogenous 5-HT3 receptors in pathogenic mechanisms involved colonic inflammation, especially relation to substance P (SP) neurokinin-1 (NK1 ) receptor.The effects NK1 receptor antagonists were examined dextran sulphate sodium (DSS)-induced colitis mice. Inflammatory mediator expression distribution also determined.Daily administration ramosetron...
Although NADPH oxidase 1 (NOX1) has been shown to be highly expressed in the gastrointestinal tract, physiological and pathophysiological roles of this enzyme are not yet fully understood. In present study, we investigated role NOX1 pathogenesis intestinal mucositis induced by cancer chemotherapeutic agent 5-fluorouracil (5-FU) mice. Intestinal was Nox1 knockout (Nox1KO) littermate wild-type (WT) mice via single, daily administration 5-FU for 5 days. WT mice, caused severe characterized a...
Background and Purpose The transient receptor potential vanilloid 4 (TRPV4) channel is a non‐selective cation involved in physical sensing various tissue types. present study aimed to elucidate the function expression of TRPV4 channels colonic vascular endothelial cells during dextran sulphate sodium (DSS)‐induced colitis. Experimental Approach role progression inflammation was examined murine DSS‐induced colitis model using immunohistochemical analysis, Western blotting Evans blue dye...
Non-steroidal anti-inflammatory drugs (NSAIDs), which are used for the treatment of several inflammatory disorders including rheumatoid arthritis, well known to cause gastroduodenal mucosal lesions as an adverse effect. Recently, serious problem NSAID-induced small intestinal damage has become a topic great interest gastroenterologists, since capsule endoscopy and double-balloon enteroscopy available detection lesions. Such have been concern in clinical settings, their prevention must be...
Transient receptor potential (TRP) vanilloid 1 (TRPV1) and TRP ankyrin (TRPA1), which are non-selective cation channels, play important roles in the sensation of pain. This study investigated TRPV1 TRPA1 dextran sulfate sodium (DSS)-induced murine colitis. DSS (2%) administered for 7 days caused severe colitis that was significantly less TRPV1-deficient (TRPV1KO) TRPA1-deficient (TRPA1KO) mice than wild-type (WT) mice. Similar attenuations were observed TRPV1KO TRPA1KO but not WT had been...
Abstract Background and Aim: We evaluated the effect of rebamipide (2‐(4‐chlorobenzoylamino)‐3‐[2(1H)‐quinolinon‐4‐yl] propionic acid), a novel anti‐ulcer drug, on indomethacin‐induced small intestinal lesions in rats. Methods: The animals were administered indomethacin (10 mg/kg, s.c.), they killed 24 h later. Rebamipide (30–300 mg/kg) was p.o. twice, 30 min before, 6 after indomethacin. Results: Indomethacin caused hemorrhagic rat intestine, accompanied by an increase enterobacterial...
We investigated the mechanisms underlying protective action of glucocorticoids against indomethacin-induced gastric lesions. One-week adrenalectomized rats with or without corticosterone replacement (4 mg/kg sc) were administered indomethacin (25 sc), and secretion (acid, pepsin, mucus), motility, microvascular permeability, blood glucose levels examined. Indomethacin caused lesions in sham-operated rats, an increase motility permeability as well a decrease mucus secretion. Adrenalectomy...