A5042669619- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- Lymphoma Diagnosis and Treatment
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Vascular Anomalies and Treatments
- Medical Imaging and Pathology Studies
- Veterinary Orthopedics and Neurology
- Veterinary Equine Medical Research
- Infectious Aortic and Vascular Conditions
- Pain Management and Treatment
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Climate Change and Health Impacts
- Pancreatic and Hepatic Oncology Research
- Asthma and respiratory diseases
- Knee injuries and reconstruction techniques
- Abdominal Trauma and Injuries
- Trauma and Emergency Care Studies
- Innovative Teaching Methods
- Otolaryngology and Infectious Diseases
- Spine and Intervertebral Disc Pathology
- Diversity and Career in Medicine
- Traumatic Ocular and Foreign Body Injuries
University of Wisconsin–Madison
1993-2025
University of Tennessee at Knoxville
2018-2023
Louisiana State University
2021
Karyopharm Therapeutics (United States)
2019-2020
Western University
2020
Desert Springs Hospital
2018
Auburn University
2016
Northwestern University
2014
Northwestern Memorial Hospital
2012
United States Naval Research Laboratory
1987
Standard treatment of patients with stage II/III esophageal or gastroesophageal junction (E/GEJ) cancer involves neoadjuvant chemoradiation (nCRT), resection, and immunotherapy. Our trial evaluated the addition perioperative avelumab to standard treatments.
Objective- The purpose of the study was to describe variables affecting thigh girth measurements preoperatively and two weeks after surgical stabilization stifle examine inter- intra-observer reliability. Animals- Ten hound-type dogs with expiermental unilateral, cranial cruciate ligament transection stabilization. Procedures- Dogs were placed in lateral recumbency for circumference placement flexed (F), estimated standing (S), extended (E) positions. Measurements made at 50 70% length (TL),...
4034 Background: Neoadjuvant CRT followed by surgery is the standard of care for patients (pts) with stage II/III E/GEJ cancer, yet recurrence rates remain high. Immunotherapy has demonstrated activity in advanced cancer and was recently approved adjuvant treatment early disease. This trial evaluated safety efficacy avelumab perioperative resectable cancer. Methods: a two part phase I/II trial. Phase I run-in 6 pts. II planned to enroll an additional 18 pts expansion cohort. Pts...
4041 Background: Neoadjuvant CRT followed by surgery is the standard of care (SOC) for patients (pts) with stage II/III E/GEJ cancer. However, recurrence rates are high. Immunotherapy has demonstrated promising activity in advanced This trial evaluates safety and efficacy perioperative A resectable Methods: a 2-part phase I/II trial. Part 1 run-in 6 pts evaluation. 2 will enroll additional 18 expansion cohort. Pts cancer any histology receive (41.4 Gy 23 fractions) carboplatin paclitaxel as...
Both Red Blood Cell (RBC) transfusion and anemia are thought to negatively impact cancer survival. These effects have been reported with mixed findings in of the esophagus. The potential application restrictive strategies on this patient population has not defined.We conducted a retrospective study esophagectomies studied cases based whether they were anemic or transfused peri-operatively. Clinical characteristics known clinicopathologic prognosticators compared between these groups....
OPEN ACCESSJune 17, 2014Surgery Boot Camp Nabil Issa, MD, Jonathan Fryer, Mamta Swaroop, Daniel McCarthy, Jeffrey Wayne, Shari Meyerson, Debra DaRosa, PhD MD Northwestern University The Feinberg School of Medicine , https://doi.org/10.15766/mep_2374-8265.9820 SectionsAbout ToolsDownload Citations ShareFacebookTwitterEmail AbstractAbstractThis resource is a 1-day course for incoming surgery residents to help decrease their anxiety and prepare them roles as surgical interns. comprised five...
To improve the accuracy of drilling during repair sacroiliac luxations (SILs) with a 3D-printed patient-specific drill guide (3D-GDT) compared to free-hand technique (FHDT).Blinded, randomized, prospective ex vivo study.Sixteen canine cadavers (20-25 kg).Dorsal, bilateral SILs were created. Pelvic CT was performed pre- and post-drilling. The FHDT drilled followed by 3D-GDT. 3D measurements craniocaudal dorsoventral angles between 3D-GDT, as well deviations entry exit points relative optimal...
Introduction: Patients (pts) with R/R DLBCL who have received at least 2 lines of therapy, including pts progressed post stem cell transplantation (SCT) or are not candidates for SCT, limited treatment options. Active novel therapies different mechanisms actions needed to improve the survival these pts. Selinexor, a selective oral XPO1 inhibitor, leads nuclear accumulation and activation tumor suppressor proteins (e.g., p53, p21, IkB), reductions in c-Myc Bcl-2 oncogenes. Single agent...
Objective To assess the performance of an active patient‐warming device. Materials and Methods Temperatures device (HotDog system) were measured at various time points using infrared thermometer. The study was conducted in two phases: Phase 1 compared temperatures among four different areas warming blanket. 2 conditions simulating scenarios a weighted patient simulator. Results 1: Three out positions on blanket had significantly temperature measurements. 2: Temperature output by reduced: (1)...
To characterize the clinical features among dogs sustaining rib fractures and to determine if age, type severity of injury, entry blood lactate, trauma score fracture were associated with outcome. A retrospective study was performed include that presented fractures. Risk factors evaluation included breed, body weight, diagnosis, presence a flail chest, bandage use, puncture wound presence, number, location along thoracic wall, hospital stay length, other fractures, pleural effusion,...
TPS181 Background: Neoadjuvant chemoradiation (CRT) followed by resection is the standard treatment for patients with stage II and III esophageal cancer. However, about 50% of develop recurrent disease after completion. Patients residual at time (~ 75%) especially those persistent lymph node involvement have worst prognosis. Hence, novel strategies are needed to improve outcomes. A number preclinical clinical studies demonstrated synergism between radiation immunotherapy. In cancers, CRT has...
Abstract OBJECTIVE Patient factors may alter laser photon attenuation, but these have not been adequately evaluated in live dogs. Our objective was to evaluate class IV beam attenuation (LBA) by canine tissues using a colorimeter melanin and erythema indices. We hypothesized that greater indices unclipped hair would increase LBA, properties vary among tissues. ANIMALS 20 client-owned PROCEDURES Between October 1 December 1, 2017, measurements LBA various before after clipping overlying were...
Aorto-tracheal fistulas are rare and highly lethal, with few reports of successful surgical intervention. We present a 48 year old man aorto-tracheal fistula induced by radiation therapy for tracheal squamous cell carcinoma. He presented hemoptysis chest pain workup revealed the aorta-tracheal between posterior aortic arch anterior distal trachea. was emergently taken to surgery. To our knowledge, this is first report an successfully treated transverse replacement complex repair using...
Aorto-tracheal fistulas are rare and highly lethal, with few reports of successful surgical intervention. We present a 48-year-old man an aorto-tracheal fistula induced by radiation therapy for tracheal squamous cell carcinoma. He presented hemoptysis chest pain workup revealed the aorta-tracheal between posterior aortic arch anterior distal trachea. was emergently taken to surgery. To our knowledge, this is first report successfully treated transverse replacement complex repair using...
To evaluate the association of various leukocytes with pulmonary resist ance and methacholine responsiveness, we induced eosi‐nophil‐rich inflammation in IgE‐sensitized (ovalbumin) Sprague Dawlcy rats. Sensitized rats were challenged either relevant (OA) or irrele vant antigen by tracheal insufflation a) no other treatment, b) conjunction intravenous Sephadex beads pretrcatment, c) coupled covalently to Sepharose heads. About 24 h after challenge, respiratory system resistance (Rrs),...
Objective We investigated the impact of body mass index (BMI) on post-operative outcomes and survival patients with interstitial pulmonary fibrosis (IPF) undergoing lung transplantation. Methods retrospectively reviewed 222 IPF that underwent transplant (LT) at our institution from 2005 to 2019. Recipients were divided in 4 groups: group-1 consisted underweight (BMI ≤18.5 kg/m 2 ), group-2 normal weight 18.5–25 group-3 over-weight 25–29.9 ) group-4 obese ≥30 ). Results Group-1 13 (6%)...