A5069579945- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Oral Health Pathology and Treatment
- Blood groups and transfusion
- Oral and gingival health research
- HIV/AIDS oral health manifestations
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Potassium and Related Disorders
- Hepatitis B Virus Studies
- Religion, Spirituality, and Psychology
- Tuberculosis Research and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- Erythrocyte Function and Pathophysiology
- Child Nutrition and Water Access
- Neuroblastoma Research and Treatments
Memorial Foundation
2019-2023
North Middlesex Hospital
2006
Thalassemia is the leading haemoglobinopathy after sickle cell anemia that accounts for 1.5 % of global population. In Pakistan, every 1-4 per 1000 infants suffers from Thalassemia. Regardless being a population "at high risk" major, evidence suggest Pakistanis possess poor knowledge disease. The present study aimed to assess parents' accurate about disease at Afzaal Memorial Foundation in Karachi, Pakistan. A total 172 parents existing patients who were receiving regular blood transfusion...
Objective: To describe the initial experience and demographics of T2* cardiac magnetic resonance–based myocardial-iron quantification transfusion-dependent thalassemia-major (TM) patients from Pakistan correlation with serum ferritin. Methods: Eligible TM presenting between April 2014 2015 to Aga Khan University Hospital, Pakistan, for T2*CMR were included. The severity deposition was defined as follows: normal T2*>20 ms, mild-moderate T2*10 20 severe T2*<10 ms. Cardiac symptoms...
Abstract Background Endocrinopathy due to iron overload is the most common morbidity whereas myocardial siderosis causing toxic cardiomyopathy leading cause of mortality among patients with transfusion dependent thalassemia major (TDTM). If detected early, this can be treated aggressive chelation. T2* cardiac magnetic resonance imaging (CMR) guided chelation protocols are now gold standard but have limited availability in low and middle‐income countries. We hypothesized that markers...
The aim of this study was to establish multidisciplinary care for patients with transfusion-dependent thalassaemia (TDT) by creating a TDT quality improvement (QI) collaborative in resource-constrained setting. This presents our initial experience collaborative, the baseline characteristics participants, proposed QI interventions and outcome metrics collaborative.TDT is database comprising from four centres Karachi, Pakistan. Study variables included symptoms cardiac or endocrine...
We report the case of a girl with multi-focal hepatoblastoma in whom chemotherapy alone has resulted long term event-free survival and possibly cure, without any surgical procedure apart from biopsy for initial diagnosis. At presentation she had large tumour arising left lobe liver two other separate masses were noted right lobe, but lungs free metastases. Histology showed foetal type hepatoblastoma. The serum alpha-feto protein (AFP) level was 44,000 iu/litre. Chemotherapy started using...
Thalassemia major is a severe hereditary blood disorder that poses significant health challenges, particularly in regions with high prevalence rates. The distribution of thalassemia has been observed to vary ethnicity and group, yet few studies have explored these associations within the Pakistani population. Objective: This study aimed determine association between major, groups, among Methods: case-control was conducted retrospectively using data from center Karachi, Pakistan. included...
Periodontal diseases and Thalassemia Major (TM), which are two chronic inflammatory diseases, associated with increased levels of proinflammatory cytokines in bio-fluids. Interleukin (IL)-6 IL-8 have been identified as potent biomarkers periodontal well patients &beta;-thalassemia (TM-&beta;). This suggests that TM-&beta; gingival inflammation conditions, each may affect the other. The objective this pioneer research was to evaluate effect oral hygiene maintenance care on serum...
Abstract Background Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in Mediterranean, Middle East and South Asia. Over past 40 years, awareness prevention campaigns many countries have greatly reduced incidence affected child births. In contrast, much remains to be done South-Asia. Thus, for Pakistan, an estimated ~ 7000 children annually are born thalassemia, no sign improvement. Although there good agreement that intermarriage carriers...
Background: Increased prevalence of gingival diseases in thalassemia patients has been consistently reported. In with neutrophil dysfunctions, periodontal tissue is lost very rapidly. \(\beta\)-thalassemia major (TM- \(\beta\)) exhibit defective neutrophils and macrophages. Therefore, supplementary inflammation detrimental to tissues these patients. This warrants attention specialized oral health care intervention the pioneer pre post study that evaluates effect non-surgical therapy (NSPT)...
This article presents a longitudinal study of symptomatic anxiety in Beta-Thalassemia patients categorically adolescents (both male and female). was conducted at Thalassemia center(Afzaal Memorial Foundation,Karachi). Sampleswereselected through purposive sampling. The sampling population comprised 196 registered patientswith age range between 4and 17 years.The overall percentage indicated patientsas 63.26%.Among levels anxiety, we observed mild symptoms comparedto moderate severe. An...
Abstract Abstract: Background : Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in Mediterranean, Middle East and South Asia. Over past 40 years, many countries have implemented awareness prevention campaigns that greatly reduced incidence affected child births. In contrast, much remains to be done South-Asia. Thus, for Pakistan, current estimates number children born thalassemia are at ~7,000 per annum, no sign improvement. Although there...
Abstract Background : Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in Mediterranean, Middle East and South Asia. Over past 40 years, many countries have implemented awareness prevention campaigns that greatly reduced incidence affected child births. In contrast, much remains to be done South-Asia. Thus, for Pakistan, current estimates number children born thalassemia are at ~7,000 per annum, no sign improvement. Although there good...
Abstract Background : Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in Mediterranean, Middle East and South Asia. Over past 40 years, many countries have implemented awareness prevention campaigns that greatly reduced incidence affected child births. In contrast, much remains to be done South-Asia. Thus, for Pakistan, current estimates number children born thalassemia are at ~7,000 per annum, no sign improvement. Although there good...
Abstract Abstract: Background : Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in Mediterranean, Middle East and South Asia. Over past 40 years, many countries have implemented awareness prevention campaigns that greatly reduced incidence affected child births. In contrast, much remains to be done South-Asia. Thus, for Pakistan, current estimates number children born thalassemia are at ~7,000 per annum, no sign improvement. Although there...
Abstract Abstract: Background : Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in Mediterranean, Middle East and South Asia. Over past 40 years, many countries have implemented awareness prevention campaigns that greatly reduced incidence affected child births. In contrast, much remains to be done South-Asia. Thus, for Pakistan, current estimates number children born thalassemia are at ~7,000 per annum, no sign improvement. Although there...