A5061382766- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Genetics and Physical Performance
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Cholinesterase and Neurodegenerative Diseases
Karolinska Institutet
2020-2021
Rockefeller University
2013-2017
Abstract Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic generation and distribution stromal cells across different lesions the brain spinal cord has not been systematically investigated mice humans. Furthermore, it is unknown whether scar-forming have same origin throughout types lesions. In current study, we compared scarring human pathological corresponding mouse models penetrating non-penetrating injury, traumatic ischemic stroke,...
Endurance exercise promotes skeletal muscle vascularization, oxidative metabolism, fiber-type switching, and neuromuscular junction integrity. Importantly, the metabolic contractile properties of fiber must be coupled to identity innervating motor neuron (MN). Here, we show that muscle-derived neurturin (NRTN) acts on fibers MNs couple their characteristics. Using a muscle-specific NRTN transgenic mouse (HSA-NRTN) RNA sequencing MN somas, observed retrograde signaling shift toward slow...
Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which generated through sequential proteolysis amyloid precursor protein (APP), first action β-secretase, generating β-C-terminal fragment (βCTF), and then Presenilin 1 (PS1) enzyme in γ-secretase complex, Aβ. γ-Secretase an intramembranous complex composed Aph1, Pen2, Nicastrin, 1. Although it has a central role pathogenesis AD, knowledge mechanisms that regulate PS1 function limited. Here, we show...
Macroautophagy (autophagy) is a conserved cellular pathway that regulates the degradation of long-lived proteins, protein aggregates, and organelles. Autophagy essential for maintaining neuronal homeostasis; however, autophagic efficiency decreases with age. Therefore, aging one greatest risk factors development Alzheimer's disease (AD), slowly progressing form neurodegeneration develops over course 10-20 years prior to onset overt clinical symptoms. AD defined neuropathologically by...
Increasing exercise capacity promotes healthy aging and is strongly associated with lower mortality rates. In this study, we analyzed skeletal muscle transcriptomics coupled to performance in humans rats dissect the inherent response components of aerobic capacity. Using rat models selected for intrinsic acquired capacity, determined that high transcriptome pathways tissue oxygenation vascularization. Conversely, low indicated immune metabolic dysfunction. Low training was an inflammatory...
Abstract Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic generation and distribution stromal cells across different lesions the brain spinal cord has not been systematically investigated mice humans. Furthermore, it is unknown whether scar-forming have same origin throughout types lesions. In current study, we compared scarring human pathological corresponding mouse models penetrating non-penetrating injury, traumatic ischemic stroke,...
SUMMARY Endurance exercise promotes skeletal muscle vascularization, oxidative metabolism, fiber-type switching, and neuromuscular junction integrity. Importantly, the metabolic contractile properties of fiber must be coupled to identity innervating motor neuron (MN). Here, we show that muscle-derived neurturin (NRTN) acts on fibers MNs couple their characteristics. Using a muscle-specific NRTN transgenic mouse (HSA-NRTN) RNA-sequencing MN somas, observed retrograde signaling shift towards...