A5076279326- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Neonatal Respiratory Health Research
- Evolutionary Psychology and Human Behavior
- Neuroscience and Neuropharmacology Research
- Sexuality, Behavior, and Technology
- Wound Healing and Treatments
- Sexual function and dysfunction studies
Karolinska Institutet
2011-2024
There is limited regeneration of lost tissue after central nervous system injury, and the lesion sealed with a scar. The role scar, which often referred to as glial scar because its abundance astrocytes, complex has been discussed for more than century. Here we show that specific pericyte subtype gives rise scar-forming stromal cells, outnumber in injured spinal cord. Blocking generation progeny by this results failure seal tissue. formation connective common many injuries pathologies, here...
Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced pathological situations. We report that stroke elicits a latent neurogenic program striatal astrocytes mice. Notch1 signaling reduced after stroke, and attenuated necessary for neurogenesis by astrocytes. Blocking Notch triggers striatum medial cortex to enter program, even absence of resulting 850 ± 210 (mean SEM) new mouse striatum. Thus, under regulation, brain...
CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to block axonal regeneration, resulting in permanent functional deficits. We report inhibiting generation of progeny by a subclass pericytes led decreased fibrosis and extracellular matrix deposition after spinal cord mice. Regeneration raphespinal corticospinal tract axons was enhanced sensorimotor function recovery improved following animals with attenuated pericyte-derived scarring. Using...
Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of scar, as it is made several different cell types, which may limit damage but also inhibit axonal regrowth. We show that scarring neural stem cell-derived astrocytes required restrict secondary enlargement lesion and further loss after spinal cord injury. Moreover, progeny exerts a neurotrophic effect for survival neurons adjacent lesion. One distinct component glial...
Abstract Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic generation and distribution stromal cells across different lesions the brain spinal cord has not been systematically investigated mice humans. Furthermore, it is unknown whether scar-forming have same origin throughout types lesions. In current study, we compared scarring human pathological corresponding mouse models penetrating non-penetrating injury, traumatic ischemic stroke,...
Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed that enlarges upon vasodilation, but its regulation not completely understood. Here, we show perivascular fibroblasts in cavernosa support vasodilation reducing norepinephrine availability. The effect on penile blood flow depends number of fibroblasts, which regulated erectile activity. Erection dynamically alters positional arrangement temporarily down-regulating Notch signaling. Inhibition increases...
Abstract Fibrotic scar tissue formation occurs in humans and mice. The fibrotic impairs regeneration functional recovery. However, the origin of scar-forming fibroblasts is unclear. Here, we show that stromal forming derive from two populations perivascular cells after spinal cord injury (SCI) adult mice both sexes. We anatomically transcriptionally identify cell as pericytes fibroblasts. Fibroblasts are enriched white gray matter regions cord, respectively. Both recruited response to SCI...
Abstract Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic generation and distribution stromal cells across different lesions the brain spinal cord has not been systematically investigated mice humans. Furthermore, it is unknown whether scar-forming have same origin throughout types lesions. In current study, we compared scarring human pathological corresponding mouse models penetrating non-penetrating injury, traumatic ischemic stroke,...
Astrocytes have emerged as a potential source for new neurons in the adult mammalian brain. In mice, striatal neurogenesis can be stimulated by local damage, which recruits astrocytes into neurogenic program suppression of active Notch signaling (J. P. Magnusson et al., Science 346, 237-241 [2014]). Here, we induced intact mouse brain inhibition astrocytes. We show that most astrocyte-derived are confined to anterior medial striatum, do not express established neuronal markers, and exhibit...