A5059954903- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Ovarian cancer diagnosis and treatment
- Genital Health and Disease
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Reproductive Biology and Fertility
- Hormonal Regulation and Hypertension
- Gastric Cancer Management and Outcomes
- Sexual Differentiation and Disorders
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Ovarian function and disorders
- Parvovirus B19 Infection Studies
- Animal Genetics and Reproduction
- Bladder and Urothelial Cancer Treatments
- Economic and Financial Impacts of Cancer
- Effects of Radiation Exposure
- Sperm and Testicular Function
- Prenatal Screening and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Retinal and Macular Surgery
- Intraperitoneal and Appendiceal Malignancies
Universidad Nacional Autónoma de México
2013-2025
Hospital Universitario La Paz
2019-2024
NYU Langone Health
2023
Winthrop-University Hospital
2016-2021
Universidad de Oviedo
2019
University Hospital Complex Of Vigo
2014-2016
Complexo Hospitalario Universitario A Coruña
2014
Instituto Nacional de Cancerología
2009
In-Q-Tel
2009
Maternal low-protein diets (LP) impair pancreatic β-cell development, resulting in later-life failure and susceptibility to type 2 diabetes (T2D). We hypothesized that intrauterine and/or postnatal developmental programming seen this situation involve altered structure relative time course of expression genes critical differentiation growth. Pregnant Wistar rats were fed either control (C) 20% or restricted (R) 6% protein during pregnancy (1st letter) lactation (2nd four groups: CC, RR, RC,...
Encapsulin nanocompartments (ENCs), or simply encapsulins, are a novel type of protein nanocage found in bacteria and archaea. The complete encapsulin systems include cargoes involved specific metabolic tasks. Cargoes selectively encapsulated due to the presence cargo-loading peptide (CLP). However, heterologous proteins fused CLP have also been successfully encapsulated, making encapsulins very promising system for protein-carrying delivery. Nevertheless, precise cell tissue delivery,...
Previous evidence suggests a link between the ovarian surface epithelium and cortical inclusion cysts origin of epithelial cancer. The presence 17β-hydroxysteroid dehydrogenase type I, aromatase, estrogen receptor alpha has previously been demonstrated in these components human ovary. aim this study was to provide further on enzymes involved biosynthesis ovaries women ages 23 80. Our results were obtained via immunohistochemistry formalin-fixed, paraffin-embedded tissue samples from patients...
Serum levels of CA125 measured before any treatment have been evaluated in epithelial ovarian cancer (EOC) as a predictor patient survival; however, results survival index are controversial, influenced by several variables. Taking this into consideration, the present study association pretreatment serum with clinical stage, histology and differentiation grade tumor rate group patients from an oncology referral center Mexico, all them diagnosed carcinoma. This retrospective consisted 1009...
Ovarian cancer is the most lethal of all gynecologic malignancies. The relationship between sexual steroids receptors and ovarian progression has been largely evaluated. presence progesterone associated with an increase a disease-free period overall survival in patients carcinoma. In present study, primary cultures carcinoma obtained from 35 diagnosed epithelial were evaluated for cell after treatment 10− 8 M 17β-estradiol, progesterone, testosterone dihydrotestosterone. results analyzed...
Previous studies show that androgens are involved in hypertrophy and excitability of cardiomyocytes their effects mediated through receptor. The aim this study was to evaluate the presence androgen receptor (AR) mouse heart during prenatal early postnatal stages.The expression AR related genes, alpha myosin heavy chain -Myh6-, beta -Myh7- atrial natriuretic factor -Nppa- simultaneously evaluated by semiquantitative RT-PCR. also detected immunohistochemistry. Androgen mRNA hearts from 10.5...
The significance of the presence androgen receptor (AR), estrogen alpha (ER) and progesterone (PR) in ovarian cancer patient survival has been a matter numerous studies. This study was aimed to describe expression profile three sexual steroid receptors high-grade serous, endometrioid, mucinous low-grade serous carcinoma its association proliferation index patients with primary diagnosis, before any treatment. Eighty-one samples were obtained from National Institute Cancerology Mexico City...
The aim of the present study was to evaluate effect hypophysectomy on cell proliferation in left ovary and testis 8– 14–day–old chick embryos. Hypophysectomy performed by partial decapitation technique. At 44–46 h incubation, embryo heads were sectioned at mesencephalic level prosencephalic region removed. Embryos further incubated until 8–14 days development. Cell division evaluated bromodeoxyuridine (BrdU) incorporation counting total number somatic germ cells gonads. displayed an...
The current study evaluated the metalloproteinases MMP-2 and MMP-9 expression in epithelial cells surrounding stroma ovarian tumors association of MMPs with histological subtypes, clinical stage presence steroid hormone receptors. Tumor samples were obtained from 88 patients undergoing surgical cytoreduction primary Instituto Nacional de Cancerología, México City. formalin fixed paraffin embedded processed order to demonstrate androgen receptor,estrogen receptor alpha, progesterone receptor,...
The incidence of ovarian cancer has been epidemiologically related to female reproductive events and hormone replacement therapy after menopause. This highlights the importance evaluating role sexual steroid hormones in by expression enzymes biosynthesis tumor cells. study was aimed evaluate presence 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), aromatase estrogen receptor alpha (ERα) cells their association with overall survival 111 patients diagnosed primary tumors. Positive...
Abstract Background Ovarian cancer is usually diagnosed at an advanced stage due to its early asymptomatic course and late-stage non-specific symptoms. This highlights the importance of researching molecular mechanisms involved in ovarian carcinogenesis as well discovery novel prognostic markers that could help improve survival outcome patients. The aim this study was evaluate expression steroid sulfatase (STS) 154 samples primary tumors. protein crucial intracellular conversion sulfated...
The importance of surface epithelium and epithelial inclusion cysts in the ovary arises from studies demonstrating that these structures are susceptible to ovarian cancer development. expression estrogen receptor alpha (ER alpha), androgen (AR), cells premenopausal postmenopausal women is interesting because sexual steroid hormones involved cell growth differentiation. presence ER alpha, AR, orphan G protein-coupled 30 (GPR30) was demonstrated by immunofluorescence ovaries obtained 79 pre...
Virus-like nanoparticles (VLNPs) are an excellent alternative for the polyvalent display of peptides and proteins with a broad spectrum enzymatic other activities, which allow targeted delivery bioactive molecules. Precise targeting is limiting step in application selective therapies that otherwise can produce adverse side effects on off-target sites. In this research, we took advantage ability structural domain VP2 parvovirus B19 to coassemble chimeric forms itself VLNPs. Two chimeras VP2,...
Gastric adenocarcinoma (GA) is a significant global health issue with poor prognosis, despite advancements in treatment. Although molecular classifications, such as The Cancer Genome Atlas (TCGA), provide valuable insights, their clinical utility remains limited. We performed multi-layered functional analysis using TCGA RNA sequencing data to better define subtypes and explore therapeutic implications. reanalyzed RNA-seq from 142 GA patients localized disease who received adjuvant...
Androgen effects, mediated by the androgen receptor, regulate important cellular processes such as growth, proliferation, and differentiation. The presence of receptor has been described in structures central nervous system, mainly advanced fetuses, newborns, adult animals. This study describes location early developmental stages system. mRNA was evidenced through reverse transcriptase-PCR protein immunohistochemistry western blot techniques cerebral vesicles 9.5-day mouse embryos chicken at...