A5038207247- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and characterization of novel inorganic/organometallic compounds
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Organoboron and organosilicon chemistry
- Metal complexes synthesis and properties
- Coordination Chemistry and Organometallics
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- Crystal structures of chemical compounds
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Advanced Cellulose Research Studies
- Endometrial and Cervical Cancer Treatments
- Reproductive Biology and Fertility
- Metal-Organic Frameworks: Synthesis and Applications
- Maternal and fetal healthcare
- Catalytic Cross-Coupling Reactions
- Ferrocene Chemistry and Applications
- Silicone and Siloxane Chemistry
- Uterine Myomas and Treatments
- Synthesis of Organic Compounds
- Cervical Cancer and HPV Research
- Polyoxometalates: Synthesis and Applications
- Synthesis and biological activity
Saarland University
2016-2025
International Centre for Diffraction Data
2025
University of Cologne
2014-2024
University Hospital Cologne
2013-2024
Solid State Physics Laboratory
2021
Universitäts Frauenklinik
2020
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2020
Klinik für Frauenheilkunde
2014-2019
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2014-2019
Klinik und Poliklinik für Urologie
2016-2018
Abstract Angiogenesis is essential for the development of malignant tumors and provides important targets tumor diagnosis therapy. To noninvasively assess angiogenic profile tumors, novel αvβ3 integrin–targeted ultrasmall superparamagnetic iron oxide particles (USPIOs) were designed their specific uptake by endothelial cells was evaluated in vitro vivo. USPIOs coated with 3-aminopropyltrimethoxysilane (APTMS) conjugated Arg-Gly-Asp (RGD) peptides. Accumulation human umbilical vein (HUVECs)...
Abstract Homobimetallic dimetallocenes exhibiting two identical metal atoms sandwiched between η 5 bonded cyclopentadienyl rings is a narrow class of compounds, with representative examples being dizincocene and diberyllocene. Here we report the synthesis structural characterization heterobimetallic dimetallocene, accessible through heterocoupling lithium aluminylene fragments pentaisopropylcyclopentadienyl ligands. The Al–Li bond features high ionic character profits from attractive...
Aluminata‐silenes are the elusive heavier counterparts of well‐known borataalkenes in which B=C double bond is formally replaced by an Al=Si moiety. We report isolation a four‐membered anionic AlSi3 cycle with bona fide bond, obtained reaction 2 eq. disilenide Tip2Si=SiTipLi H2AlCl (Tip = 2,4,6‐triisopropylphenyl). X‐ray crystallography, UV‐vis spectroscopy and computational analysis confirm character very short Al‐Si 2.283(1) Å high Wiberg index (WBI) 1.31. Intramolecular C‐H activation...
Whereas triplet-nitrene complexes of the late transition metals are isolable and key intermediates in catalysis, singlet-nitrene ligands remain elusive. Herein we communicate three such palladium terminal imido with singlet ground states. UV–vis–NIR electronic spectroscopy broad bands up to 1400 nm as well high-level computations (DFT, STEOM-CCSD, CASSCF/NEVPT2, EOS analysis) reactivity studies suggest significant palladium(0) character. Although aliphatic nitrene proved be too reactive for...
Starting from tetrakis(trimethylsilyl)cyclobutadiene and an amidinate-supported silylene of the Roesky-type, a sequence addition reduction cleanly gives elusive silapyramidane via isolable cyclobutene intermediate with exocyclic Si═C bond. The features unusually shielded 29Si NMR resonance at -448.3 ppm for apex silicon atom. Treatment Fe2(CO)9 results in formation corresponding silapyramidane-iron complex. Silapyramidane also reacts cyclobutadiene starting material to afford fluorescent...
Lithium- and magnesium complexes of a CNC pincer ligand composed carbazole two mesoionic carbenes are bright luminescent, because the metals prevent molecular distortions upon excitation.
More than 99% of cervical cancers and up to 40% vulvar are human papillomavirus (HPV) related. HPV 16 18 the most relevant subtypes. Novel technologies allow detection minimal amounts circulating cell-free DNA (ccfHPV-DNA). The aim this study was evaluate ccfHPV-DNA assessed by droplet digital PCR (ddPCR) as a biomarker for molecular therapy monitoring in early, advanced, relapsed metastatic HPV-driven cancer.Inclusion criteria were histologically proven 16/18-driven cancer with first...
Tactics with taci: Strong ferromagnetic interactions (up to ≈150 cm−1) and an S=3 ground state have been observed in the octanuclear vanadyl cluster [V8O14(H−2taci)2] (taci=1,3,5-triamino-1,3,5-trideoxy-cis-inositol; see structure: V yellow, O red, N blue, C black) where polydentate taci ligand forces some of coordination polyhedra into a mutually orthogonal arrangement. Ab initio DFT calculations confirm magnetostructural analysis.
Inclusion compounds of cationic, anionic, and neutral p-substituted derivatives tert-butylbenzene complexed in beta-cyclodextrin its ionic 6-mono 6-hepta were systematically investigated by isothermal titration calorimetry (ITC). All inclusion showed 1:1 stoichiometry with binding constants ranging from 10 to 3 x 10(6) M(-1). The free energies could be subdivided into apolar electrostatic contributions. interactions quantitatively described Coulomb's law taking account the degree protonation...
Electrophilic AlIII species have long dominated the aluminum reactivity towards arenes. Recently, nucleophilic low-valent AlI aluminyl anions showcased oxidative additions arenes C-C and/or C-H bonds. Herein, we communicate compelling evidence of an AlII radical addition reaction to benzene ring. The electron reduction a ligand stabilized precursor with KC8 in furnishes double ring instead bond activation, producing corresponding cyclohexa-1,3(orl,4)-dienes as Birch-type product. X-ray...
Ionic liquids are attractive liquid materials for many advanced applications. For targeted design, in-depth knowledge about their structure-property-relations is urgently needed. We prepared a set of novel protic ionic (PILs) with guanidinium cation either an ether or alkyl side chain and different anions. While being promising class, the available data insufficient to guide design. measured thermal transport properties, nuclear magnetic resonance (NMR) spectra as well crystalline structures...
Reaction of the pincer-type ligand L
We present the isolation and reactivity of terminal gold(I) imido complexes, report on effect capping alkali-cations. These anionic strongly basic “super”-imide complexes engage in CH-bond auration including benzene pyridine. They also mediate dehydrogenation dihydroanthracene cyclohexadiene under generation dihydrogen or elimination sodium hydride. Mechanistic investigations (kinetics, isotope effects) quantum chemical calculations reveal that coordinating alkali-cations control complexes’...
The oxidation of triphenylphosphine by perfluorinated phenaziniumF aluminate in difluorobenzene affords the hexaaryl-1,2-di¬phosphonium dialuminate 1. Dication 12+ is isoelectronic with elusive hexaphenylethane, where instead formation a mixture trityl radical and Gomberg’s dimer favored. Quantum-chemical calculations combination Raman/IR spectroscopies rationalize stability P–P bonded suggest, akin to halogens, facile homolytic as well heterolytic scission. Thus, serves surrogate both...
Aluminata‐silenes are the elusive heavier counterparts of well‐known borataalkenes in which B=C double bond is formally replaced by an Al=Si moiety. We report isolation a four‐membered anionic AlSi3 cycle with bona fide bond, obtained reaction 2 eq. disilenide Tip2Si=SiTipLi H2AlCl (Tip = 2,4,6‐triisopropylphenyl). X‐ray crystallography, UV‐vis spectroscopy and computational analysis confirm character very short Al‐Si 2.283(1) Å high Wiberg index (WBI) 1.31. Intramolecular C‐H activation...
Hyperforin is considered the flagship congener among polycyclic polyprenylated acylphloroglucinols due to its compelling and complex molecular architecture, coupled with remarkable biological activity, thus rendering it an appealing synthetic target for chemists over past two decades. Herein, innovative linear total synthesis of hyperforin reported. Our relies on formation bicyclo[3.3.1]nonane-2,4,9-trione framework via transannular acylation a decorated eight-membered ring, followed by late...
The transformation of the greenhouse gas CO 2 into value-added products represents a major contemporary challenge. Low-valent p-block compounds typically react at oxygen termini due to oxophilicity...