A5025580220- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Bone health and osteoporosis research
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Vitamin D Research Studies
- Elbow and Forearm Trauma Treatment
- Shoulder and Clavicle Injuries
- Knee injuries and reconstruction techniques
- Orthopedic Infections and Treatments
- Bone and Joint Diseases
- Bone health and treatments
- Transplantation: Methods and Outcomes
- Surgical Simulation and Training
- Cardiac electrophysiology and arrhythmias
- Lower Extremity Biomechanics and Pathologies
- Bone fractures and treatments
- Tendon Structure and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Immunology Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Fibrosis and Remodeling
Scripps Clinic
2017-2024
Scripps Health
2017-2018
Hospital for Special Surgery
2011-2017
Stanford University
2017
Cornell University
2010-2012
Siriraj Hospital
2011
Mahidol University
2011
New York Proton Center
2011
VA San Diego Healthcare System
2006-2010
University of California, San Diego
2006
Abstract Reduction of bone turnover with bisphosphonate treatment alters mineral and matrix properties. Our objective was to investigate the effect on tissue properties near fragility fracture sites in proximal femur postmenopausal women osteoporosis. The collagen corticocancellous biopsies from were compared bisphosphonate-naive (−BIS, n = 20) bisphosphonate-treated (+BIS, 20, duration 7 ± 5 years) patients intertrochanteric (IT) subtrochanteric (ST) fractures using Fourier transform...
The minimal clinically important difference (MCID) has been defined in orthopaedics and is the smallest change that a patient considers meaningful. Less known about improvements perceives as considerable, or substantial clinical benefit (SCB). For young, highly functioning cohort with femoroacetabular impingement (FAI), SCB an measure of success.To derive for FAI treatment identify outcome score thresholds variables predictive SCB.Cohort study (diagnosis); Level evidence, 2.The modified...
Increased posterior tibial slope is associated with increased risk of anterior cruciate ligament (ACL) injury in adults. A similar association has not been rigorously examined children and adolescents.To determine whether alterations are ACL tears pediatric adolescent patients to quantify changes by age.Case-control study; Level evidence, 3.Magnetic resonance imaging (MRI) studies the knee were reviewed 3 raters blinded each other a 1:1 sample cases age- sex-matched controls. total 76...
Background: Surgical simulation has become increasingly relevant to orthopaedic surgery education and could translate improved operating room proficiency in trainees. Purpose: To compare the arthroscopic performance of junior residents who received training with a knee shoulder arthroscopy surgical simulator those didactic training. Study Design: Controlled laboratory study. Methods: Fourteen at single institution were randomized receive (n = 8) or lectures models 6). After their respective...
Background: The incidence of ulnar collateral ligament (UCL) injuries the elbow has increased in adolescents over past decade because widespread participation athletics and heightened awareness among physicians. Hypothesis: Ulnar reconstruction using docking technique would result a successful return to athletic activity this age group. Study Design: Case series; Level evidence, 4. Methods: participants were 55 skeletally mature adolescent athletes (mean age, 17.6 years; range, 15-18 years)...
Cardiac-directed expression of adenylyl cyclase type VI (AC(VI)) in mice results structurally normal hearts with basal heart rate and function but increased responses to catecholamine stimulation. We tested the hypothesis that left ventricular (LV) AC(VI) content would increase mortality after acute myocardial infarction (MI).Transgenic cardiac-directed their transgene-negative littermates (control) underwent coronary ligation, survival, infarct size, LV size were assessed 1 7 days MI. Mice...
This is a prospective randomised study comparing the clinical and radiological outcomes of uni- bipedicular balloon kyphoplasty for treatment osteoporotic vertebral compression fractures. A total 44 patients were to undergo either or kyphoplasty. Self-reported assessment using Oswestry Disability Index, Roland-Morris questionnaire visual analogue score pain was undertaken pre-operatively, at three twelve months post-operatively. The height kyphotic angle measured from pre- post-operative...
The preoperative diagnosis of hip microinstability is challenging. Although physical examination maneuvers and magnetic resonance imaging findings associated with have been described, there are limited reports radiographic features. In patients microinstability, we observed a high incidence steep drop-off on the lateral edge femoral head, which named "cliff sign."(1) To determine relationship cliff sign measurements intraoperative (2) to interobserver reliability these measurements.Cohort...
Localization of protein kinase A (PKA) via A-kinase-anchoring proteins (AKAPs) is important for cAMP responsiveness in many cellular systems, and evidence suggests that AKAPs play an role cardiac signaling. To test the importance AKAP-mediated targeting PKA on function, we designed a cell-permeable peptide, which termed trans-activator transcription (TAT)-AKAD TAT-conjugated disruptor, using binding region AKAP10 tested effects this peptide isolated myocytes Langendorff-perfused mouse...
Objective To characterize the graft survivorship and clinical outcomes of osteochondral allograft transplantation (OCA) knee in patients with an elevated body mass index (BMI). Design Prospective data on 38 consecutive a BMI ≥30 kg/m 2 treated OCA from 2000 to 2015 were reviewed. Complications, reoperations, patient responses validated outcome measures examined. Failures defined by any removal/revision or conversion arthroplasty. Results Thirty-one knees 31 (mean age, 35.4 years [range,...
Determining an accurate clinical diagnosis for nonarthritic hip pain may be challenging, as symptoms related to femoroacetabular impingement (FAI) or instability can difficult elucidate with current testing methods. In addition, commonly utilized physical examination maneuvers are static and do not include a dynamic weightbearing assessment reproduce activity-related symptoms. Therefore, implementing FAI could help improve diagnostic accuracy routine examinations of patients pain.To assess...
Femoral trochlear dysplasia is an anatomic deformity that predisposes patients to patellar instability, including subluxation and dislocation, can lead severe patellofemoral joint degeneration if left untreated. leading recurrent bilateral dislocation has rarely been reported as having a familial association. Orthopedic surgeons who encounter presenting with chronic instability no underlying disease or syndrome should be aware of the presence femoral dislocation. Although remains uncommon,...
Background: Lesions associated with posterior humeral avulsion of the glenohumeral ligament (HAGL) can lead to persistent symptoms related shoulder instability and be commonly missed or delayed in diagnosis. Purpose: To identify characterize MRI findings patients a HAGL lesion. Study Design: Case series; Level evidence, 4. Methods: This retrospective case series included 27 (28 shoulders) identified by search through senior authors’ databases, cross-reference their institutional radiologic...
A persistent question in cardiovascular gene transfer concerns whether an exogenously delivered can increase function of the failing heart. Here we test hypothesis that intracoronary delivery adenovirus encoding adenylylcyclase type VI (Ad.ACVI) setting active heart failure will As a model failure, used transgenic mice with dilated and poorly functioning hearts resulting from cardiac-directed expression Gαqq. Gαq equivalent pretreatment impairment left ventricular (LV) (echocardiography)...