A5073046043- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Advanced Fluorescence Microscopy Techniques
Hospital for Special Surgery
2017-2018
Dickinson College
2015
Recent studies have investigated the dendritic actin cytoskeleton of cell edge's lamellipodial (LP) region by experimentally decreasing activity filament nucleator and branch former, Arp2/3 complex. Here we extend these via pharmacological inhibition complex in sea urchin coelomocytes, cells that possess an unusually broad LP display correspondingly exaggerated centripetal flow. Using light electron microscopy, demonstrate drug CK666 dramatically altered architecture, slowed flow, drove a...
Treatment of large chondral defects the knee among patients aged ≥40 years remains a difficult clinical challenge owing to preexisting joint degeneration and lack treatment options short arthroplasty.To characterize survivorship, predictors failure, outcomes osteochondral allograft transplantation (OCA) years.Case series; Level evidence, 4.Prospectively collected data were reviewed for 54 consecutive who treated with OCA. Preoperative levels osteoarthritis (according Kellgren-Lawrence...
Fresh osteochondral allograft transplantation is an appealing option to address a failed cartilage repair surgical procedure, given the ability treat large lesions and subchondral osseous changes commonly seen in revision setting. We hypothesized that after would result low failure rates improved function graft incorporation on postoperative magnetic resonance imaging (MRI) correlate with superior clinical outcome.A retrospective review of prospectively collected data was used identify 43...
Background: Mosaicplasty and fresh osteochondral allograft transplantation (OCA) are popular cartilage restoration techniques that involve the single-stage implantation of viable, mature hyaline cartilage–bone dowels into chondral lesions knee. Recently, there has been greater focus on what represents a clinically relevant change in outcomes reporting, commonly applied metrics for measuring clinical significance include minimal important difference (MCID) substantial benefit (SCB). Purpose:...
Background: Condyle-specific matching for osteochondral allograft transplantation (OCA) pairs donor and recipient condyles in an attempt to minimize articular incongruity. While the majority of cartilage defects are located on medial femoral condyle, lateral more commonly available as a graft source. The purpose this study was compare clinical outcomes patients treated with non-orthotopic (lateral-to-medial condyle or medial-to-lateral condyle) OCA those traditional orthotopic...
Objective To characterize the graft survivorship and clinical outcomes of osteochondral allograft transplantation (OCA) knee in patients with an elevated body mass index (BMI). Design Prospective data on 38 consecutive a BMI ≥30 kg/m 2 treated OCA from 2000 to 2015 were reviewed. Complications, reoperations, patient responses validated outcome measures examined. Failures defined by any removal/revision or conversion arthroplasty. Results Thirty-one knees 31 (mean age, 35.4 years [range,...
Objectives: Osteochondral autograft transfer (OAT) and fresh osteochondral allograft transplantation (OCA) are popular cartilage restoration techniques that involve the single-stage implantation of viable, mature hyaline into focal chondral defects knee. Both have demonstrated good results, as defined by statistically significant post-surgical improvements in patient-reported outcome measures. Recently, there has been greater focus on what represents a clinically relevant change outcomes...
Objectives: Fresh osteochondral allograft transplantation (OCA), which transfers viable, mature hyaline cartilage and subchondral bone into full-thickness chondral defects, has demonstrated good long-term results in the knee. However, incomplete osseous trabecular integration of with host is correlated inferior patient-reported outcomes (Williams et al, JBJS, 2007) can lead to graft failure. As a result, augmentation OCA marrow aspirate concentrate (BMAC) been hypothesized improve...