A5043784230- Protein Tyrosine Phosphatases
- Renal and related cancers
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
Memorial Sloan Kettering Cancer Center
2024
Dana-Farber Cancer Institute
2022-2023
University of Veterinary Medicine Vienna
2021
Aging is associated with a decline in the number and fitness of adult stem cells
Gastroesophageal adenocarcinomas (GEAs) harbor recurrent amplification of KRAS, leading to marked overexpression WT KRAS protein. We previously demonstrated that SHP2 phosphatase, which acts promote and downstream MAPK pathway activation, is a target in these tumors when combined with MEK inhibition. hypothesized inhibitors may serve as foundation for developing novel combination inhibitor strategies therapy KRAS-amplified GEA, including targets outside the pathway. Here, we explore...
Abstract Recent studies from the cancer genome atlas (TCGA. Nature. 2014) 2017) and other groups showed that a molecular subtype with chromosomal instability (CIN) is most common of gastroesophageal adenocarcinoma (GEA) characterized by aneuploidy without somatic hypermutation. The oncogene KRAS frequently amplified in CIN type gastric (14.3%) esophageal (10.4%). SHP2 phosphatase which part machinery activating GDP-bound inactive status to GTP-bound active status, our group previously...