A5070697165- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Diet, Metabolism, and Disease
- COVID-19 Clinical Research Studies
- Digestive system and related health
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Venous Thromboembolism Diagnosis and Management
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Autoimmune and Inflammatory Disorders Research
- Blood Coagulation and Thrombosis Mechanisms
- Air Quality and Health Impacts
- Oral Health Pathology and Treatment
- Long-Term Effects of COVID-19
- Diabetic Foot Ulcer Assessment and Management
- Climate Change and Health Impacts
- Dysphagia Assessment and Management
- Vitamin D Research Studies
- Oral microbiology and periodontitis research
- Microscopic Colitis
- Child Nutrition and Water Access
- Liver Diseases and Immunity
Clínica Alemana
2020-2025
Universidad del Desarrollo
2020-2025
Aintree University Hospitals NHS Foundation Trust
2024
University of Liverpool
2024
Harvard University
2023
Hospital Regional Universitario de Málaga
2022
Instituto de Investigación Biomédica de Málaga
2022
Pontificia Universidad Católica de Chile
2012-2021
Emma Kinderziekenhuis
2017
Background: Helicobacter pylori is the most prevalent chronic bacterial infection globally, acquired mostly during childhood. It associated with gastritis, peptic ulcer disease, and gastric cancer. Due to challenges in culturing H. pylori, diagnostic reference standards often rely on combining ≥2 non-culture, biopsy-based methods. Histology Giemsa staining widely used clinical settings due its low cost reliable performance. Methods: This study evaluated concordance between histology as...
To assess gender differences in body composition (BC) a cohort of AS patients naïve to TNF-α blockers.Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS BASDAI) were reported. BC was measured by whole DXA. Body fat percentage (BF%), mass index (FMI), free (FFMI) android/gynoid ratio reported compared between men women with reference population (percentiles).Seventy consecutive included; 60% men. variables similar,...
To explore the associations between latitude and solar radiation with inflammatory bowel disease admission rates in Chile, country largest variation world.This is an ecological study, which included data on all hospital-admitted population for 2001 2012, according to different latitudes exposures Chile. The were acquired from national hospital discharge database Department of Health Statistics Information Chilean Ministry Health.Between 2012 there 12,869 admissions due (69% ulcerative...
Our main objective was to assess the relationship between body composition (BC) and response tumor necrosis factor-α (TNF-α) blocker treatment in patients with ankylosing spondylitis (AS). secondary evaluate change of BC after treatment, accounting for sex age.All included fulfilled modified New York criteria AS were naive TNF-α blocker. They followed at least 6 months start etanercept or adalimumab. The Ankylosing Spondylitis Disease Activity Score containing C-reactive protein (ASDAS-CRP)...
Abstract Background Most studies on functional gastrointestinal disorders (FGIDs) in children are based data from the northern hemisphere. Scientific reports arising South American population, but little is still known about low socio‐economic status (SES), where Helicobacter pylori infection endemic. Our objective was to evaluate prevalence of FGIDs school SES and its relationship with H. infection. Methods Children 3 public schools Santiago de Chile were included. Students completed Rome...
Frequency of Helicobacter pylori infectionin 144 school age Chilean children
Abstract Background Lactose intolerance is a frequent condition in certain populations. Different methods for diagnosis exist. There scarce literature regarding Quick Test ( LQT ) and concordance with other lactose children. Methods Prospectively, we included children who underwent gastroduodenoscopy evaluation of abdominal pain. We obtained duodenal sample blood genetic test to evaluate LCT C>T ‐13910 variant. Later, patients breath lactose, malabsorption. evaluated the between three...
Frequency and severity of periodontitis among patients with rheumatoid arthritisBackground: Periodontitis may have a triggering aggravating role various medical conditions, including arthritis.Aim: To evaluate the periodontal status in Chilean arthritis (RA), treated public hospital.Patients Methods: A trained professional conducted examination 40 RA aged 23 to 73 years (85% women).When present, its relationship gender, smoking, age, corticosteroids dose AR activity were assessed.AR was...
Introduction: Activated partial thromboplastin time (aPTT) is one of the most used coagulation tests in preoperative evaluation. Incidental detection a prolonged aPTT problem primary care, which general pediatrician should be able to attend its initial management. Objective: To describe final diagnosis patients with study. Materials and Methods: This descriptive study referred from otorhinolaryngology. Results: Totally, 508 adenoidectomies and/or tonsillectomies were performed our center, 38...
ABSTRACT Fructose is a highly abundant carbohydrate in western diet and may induce bowel symptoms children as adults. The main objective of this study to describe the frequency fructose malabsorption (FM) symptomatic patients 18 years or younger undergoing breath test single tertiary center between 2013 2018, evaluate whether certain are related positivity test. Out 273 tests 183 (67%) were compatible with FM. most frequent pretest symptom overall population was bloating (83%), followed by...
Introduction: Air pollution (AP) significantly contributes to morbidity and mortality worldwide. N-acetylcysteine (NAC) is a potent antioxidant with potential health benefits people residing in poor air quality areas. Our study aimed analyze animal studies conducted on rats mice assess the anti-inflammatory effects of NAC during exposure pollutants. Methods: A systematic search two large databases was performed. Nineteen were included this review following screening duplicates full-text...
Association of metabolic syndrome markerswith abnormal alanine aminotransferase levels in healthy children
Background: Hypercoagulability and endothelial dysfunction have been shown to be closely related both are considered as one of the main factors influencing severity COVID-19 patients. Thrombomodulin, among other factors, plays a key role an anticoagulant factor through activation protein C subsequent limitation thrombin generation. The endothelium also exerts activity under normal conditions. However, in patients, especially most severe ones, inflammatory process has trigger release cytokine...
With the increasing incidence of food allergies, presence eosinophils (Eos) in gastrointes tinal mucosa has received increased attention, particularly esophagus and colon. However, normal values for Eos count stomach duodenum pediatric patients are still limited.of this study was to estimate reference duodenal biopsies children referred upper gastrointestinal endoscopy.Cross-sectional from symptomatic endoscopy. The endoscopic report, Rapid Urease Test H. pylori, quantitative histological...