A5072033545- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Hepatitis C virus research
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Eating Disorders and Behaviors
- SARS-CoV-2 and COVID-19 Research
- Gastrointestinal Tumor Research and Treatment
- Systemic Lupus Erythematosus Research
- Regulation of Appetite and Obesity
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 detection and testing
- HIV/AIDS drug development and treatment
- Dietary Effects on Health
- Health and Medical Education
- Intestinal and Peritoneal Adhesions
- Infant Health and Development
- Cardiovascular Syncope and Autonomic Disorders
Pontificia Universidad Católica de Chile
2015-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2018-2022
Universitat Autònoma de Barcelona
2018-2019
Hebron University
2019
Landscape Research Group
2018
Hospital Clínico de la Universidad Católica
2017
Introducción: El cáncer gástrico (CG) es la primera causa de muerte oncológica en Chile. Desde 2006 autoridad sanitaria recomienda endoscopía digestiva alta (EDA) a población sintomática ≥40 años. En 2010 se estimó una cobertura EDA durante el último año este grupo 14%. Objetivo: Describir para cribado del CG Chile partir Encuesta Nacional Salud (ENS) 2016-17. Materiales y métodos: La ENS 2016- 17 realizó 6.233 encuestas adultos sobre presencia epigastralgia persistente, posible hemorragia...
High-resolution manometry (HRM) is the preferred method for evaluation of motility disorders. Recently, an update diagnostic criteria (Chicago 3.0) has been published. The aim this study was to compare performance Chicago version 2.0 (CC2.0) vs. 3.0 (CC3.0) in a cohort healthy volunteers and symptomatic patients.HRM studies asymptomatic individuals from several centers Spain Latin America were analyzed using both CC2.0 CC3.0. final diagnosis grouped into hierarchical categories: obstruction...
In a previous study, we demonstrated that women enjoyed and tolerated lower meal loads than men. Hence, hypothesized with the same load, their postprandial response is more pronounced in We performed randomized parallel trial 12 men comparing responses to palatable comfort meal. measured homeostatic sensations (hunger/satiety, fullness) hedonic (digestive well-being, mood) on 10 cm scales, vagal tone by heart ratio variability metabolomic profile before after ingestion. Gender differences...
Various conditioning factors influence the sensory response to a meal (inducible factors). We hypothesized that inherent characteristics of eater (constitutive factors) also play role. The aim this proof-of-concept study was determine role gender, as an individual constitutive factor, on meal-related experience. Randomized parallel trial in 10 women and men, comparing sensations before, during, after stepwise ingestion comfort up full satiation. Comparisons were performed by repeated...
Abstract Background Previous studies have not been able to correlate manometry findings with bolus perception. The aim of this study was evaluate correlation different variables, including traditional manometric variables (at diagnostic and extreme thresholds), esophageal shortening, transit, automated impedance ( AIM ) metrics mood passage perception in a large cohort asymptomatic individuals. Methods High resolution HRM performed healthy individuals from nine centers. Perception evaluated...
Background & AimsPatients with functional dyspepsia are believed to have increased sensitivity of the gastrointestinal tract, and some also constipation. We investigated whether in patients dyspepsia, correction dyssynergic defecation can reduce postprandial fullness.MethodsWe performed a parallel trial at 2 referral centers Spain, from June 2016 through January 2018 50 who fulfilled Rome IV criteria for distress syndrome constipation defecation. After 2-week pretreatment phase, were...
Abstract Esophageal achalasia is the most frequent primary motor disorder of esophagus, resulting in a peristalsis and failed relaxation lower esophageal sphincter (LES). Various treatments have been described. Endoscopic alternatives include botulinum toxin injection pneumatic balloon dilation, but both tend to fail with time usually repeated interventions are required. Laparoscopic Heller myotomy (LHM) has considered gold standard. The diagnosis during pregnancy extremely rare optimal...
Ingestion of a meal induces conscious sensations depending the characteristics and predisposition eater. We hypothesized that eating schedule plays conditioning role, specifically, an extemporaneous is less rewarding than when eaten at habitual schedule. conducted randomized parallel trial in 10 women men comparing responses to consistent savoury lunch-type (stewed beans) afternoon or unconventional time morning. Schedule gender differences were analyzed by repeated measures analysis...
Abstract Introduction Minute rhythm and prolonged simultaneous contractions are patterns of postprandial small bowel contractile activity that historically have been considered as suggestive mechanical intestinal obstruction; however, these also encountered in patients with motility‐like symptoms the absence obstruction. The objective this study was to determine current diagnostic outcome manometry patterns. Methods Retrospective chronic digestive evaluated by at our center between 2010...
Background Palatability of meals with identical composition has been shown to influence postprandial sensations. Our aim was determine what extent meal influences sensations independently palatability. Methods Randomized, crossover, double-blind trial comparing the responses a low-fat vs high-fat test meal, same physical and organoleptic characteristics (taste, smell, texture, color, temperature). The consisted in 150 g hummus containing either 17.7 fat (low-fat) or 22.3 (high-fat), 19.8...
Abstract Background The recently developed Brief Esophageal Dysphagia Questionnaire (BEDQ) evaluates esophageal obstructive symptoms. Its initial evaluation showed strong psychometric properties. aims of this study were to (a) translate and validate an international Spanish version BEDQ (b) evaluate its properties in a large Hispano‐American sample symptomatic individuals. Methods A was performed by experts using Delphi process reverse translation. Patients prospectively recruited from seven...
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease, induced by food allergens, clinically characterized symptoms of esophageal dysfunction. Pathologically there predominant eosinophilic inflammation. This disease relatively new, and its definitions have evolved over time. Its prevalence incidence are increasing causes clinical problems both in children adults. include impaction, dysphagia, that resemble gastroesophageal reflux, abdominal pain, vomiting. It can also...
Abstract Background Eckardt symptom score (ESS) is the most used tool for evaluation of esophageal symptoms. Recent data suggest that it might have suboptimal reliability and validity. The aims this study were as follows: (a) Develop validate an international Spanish ESS version. (b) Perform psychometric in patients with achalasia non‐achalasia patients. Methods translation was performed by Delphi process. done two different samples referred manometry. First sample: 430 dysphagia Second 161...
Fecal microbiota transplantation (FMT) is a highly effective therapy in recurrent Clostridium difficile. The best route to administrate the fecal matter has not been established yet. However, lower gastrointestinal by colonoscopy and safe, presenting higher acceptance patients. In addition, this allows an evaluation of colonic mucosa seeking for differential diagnostics. We present case series FMT performed our institution colonoscopy, highlighting outcomes practical aspects its implementation.
Abstract Background Anxiety is a significant modulator of sensitivity along the GI tract. The recently described Esophageal Hypervigilance and Score (EHAS) evaluates esophageal‐specific anxiety. aims this study were as follows: 1. translate validate an international Spanish version EHAS. 2. Evaluate its psychometric properties in large Hispano‐American sample symptomatic individuals. Methods A EHAS was developed by Delphi process reverse translation. Patients referred for high‐resolution...
Abstract Introduction Grading dysphagia is crucial for clinical management of patients. The Eckardt score (ES) the most commonly used this purpose. We aimed to compare ES with recently developed Brief Esophageal Dysphagia Questionnaire (BEDQ) in terms their correlation and discriminative capacity manometric findings evaluate effect gastroesophageal reflux symptoms on both. Methods Symptomatic patients referred high‐resolution manometry (HRM) were prospectively recruited from seven centers...